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The map label for this gene is icd2 [H]

Identifier: 59712382

GI number: 59712382

Start: 2002651

End: 2004879

Strand: Reverse

Name: icd2 [H]

Synonym: VF_1775

Alternate gene names: 59712382

Gene position: 2004879-2002651 (Counterclockwise)

Preceding gene: 59712384

Following gene: 59712376

Centisome position: 69.19

GC content: 41.14

Gene sequence:

>2229_bases
ATGACAACGCAAAAATCTAAGATTATCTATACTATCACTGATGAAGCGCCAGCATTGGCGACACATTCACTTCTTCCAAT
TATTCAAGCATTTGCAGCATCATCAGACATTGATGTTGATACACGCGACATTTCTCTTGCTGGCCGTGTAATTGCTAACT
TTCCTGAATATTTAACTGAAGATCAGCGTATTGGTGATGCATTAGCAGAGCTTGGTGAACTAGCAAAAACACCAGAAGCA
AACATTATTAAACTTCCGAATATCAGTGCGTCTATACCTCAACTTCATGCAGTAATTAAAGAGCTTCAAGCGAAAGGCTA
TGCTTTGCCTAACTACCCAGAAGAAGCAAAAACGGATGAAGAAAAAGCCGTTAAAGCGGTTTATGATAAAATTAAAGGGT
CAGCAGTAAACCCAGTATTACGTGAAGGTAACTCTGATCGTCGTGCTCCTGGAGCTGTTAAGCAATACGCTCGTAATAAT
CCTCATTCAATGGGGGCGTGGTCTTCGGATTCAAAATCACACGTAGCAAGCATGAGTGACGGTGATTTTTATTCAAGTGA
ACAATCAGTAACTATTGATGGTGCAACGAATGTAAGTATTGAGTTTGTGGCTGAAAATGGCGATATCACAGTGCTTAAAG
AAGGTCTTGCATTGCAAGATAAAGAGATCATTGATGGTTCTCGCTTAAGTAAAAAAGCACTGGTTGAATTCTTTGACGCT
GAGACTAAAAAAGCAAAAGAAGAAGATGTGTTACTTTCGCTACATATGAAAGCAACTATGATGAAAGTGTCTGATCCAGT
GATCTTTGGTCATGCCGTAAAAGTATTCTACAAAGATGTATTTGAAAAGCACGCAGCGACTTTTGAAAAACTGGGTGTTG
ATGCGAATAATGGCATTGGTGATGTTTATTCTAAAATTGCCTCTTTGCCTGAAGCTGAAAAATCACAAATTGAAGCTGAT
TTAGCTGCGGTATATGAATACCAACCTGAGCTTGCGATGGTGGATTCAGACCGTGGAATTACAAACCTTCATGTTCCTAG
TGATGTTATTATTGATGCTTCTATGCCTGCAGCACTGCGAACTTCTGGTCAAATGTGGGGACCTGATGGTCAACTCAAAG
ACACGAAAGCGATGATCCCAGATCGTTGTTATGCGGGTGTTTACCAAGCGGTAATTGATTTCTGTAAAGCAAATGGTGCA
TTTGATCCAACAACAATGGGTTCAGTACCTAATGTTGGTTTAATGGCACAAAAAGCAGAAGAGTATGGCTCTCATGATAA
AACATTCATTCTTCCTGCTGCAGGTACAGTACGAGTGATTGATGGTGCAGGTCATGCGCTTATTGAGCATGCTGTTGCTG
AAGGTGACATTTGGCGTATGTGCCAAGCTAAGGATGCACCAATTCAAGATTGGGTGAAATTAGCGGTAAATCGTGCGCGT
GCAACTGGAACACCTGCTGTTTTTTGGCTTGACGCTAATCGTTCGCATGATGCGGAGCTGATTAAAAAGGTAAATACTTA
CCTTGCAGATCACGATACAACGGGGCTAGATATTCGTATTTTAGCGCCAGTAGAGGCCACTCAGTTCTCATTAGAGCGCA
TTGTTAAAGGCGAAAATACTATTTCGGTAACAGGTAATGTATTACGTGATTATCTAACCGATTTATTCCCGATTCTTGAG
CTAGGTACATCAGCGAAAATGCTGTCGATTGTTCCTCTTATGAATGGCGGTGGTTTATTTGAAACTGGAGCGGGTGGTTC
AGCACCAAAACACGTTCAACAGTTTGAAAAAGAAAATCATTTACGTTGGGATTCTTTAGGTGAATTTTTAGCGCTTGCAG
CTTCGTTTGAGCATTTAAGTGTGACAACAGGTAATGCAAAAGCACAAATTCTGGCAGATACATTAGATGCGGCAACATCG
AAATTCTTAGAAACCAATAAATCACCATCACGTCGTGTCGGTGAGTTAGACAACCGTGGTAGCCATTTCTACCTAGCGAT
GTACTGGGCTCAAGAGCTTGCTGCACAAACAAAAGATGCAGAGCTTCAAACTTACTTTGGCTCACTGGCTGAGACATTAA
CATCAAATGAAGCAAAAATTGTTGATGAGCTTAATGCAGCACAAGGTGTTGCTGGTAATGTTGGCGGTTACTTCCAACCT
GTTGCAGAATTAGCAGCAAAAGAGATGCGTCCAAGTGCAACATTGAATGCAGCATTGTCGTCACTTTAA

Upstream 100 bases:

>100_bases
ACCAATGTAATGAATGATTAGAATTGGTATCAAAGTCGGTAAATTACAGAACCTATTATACGTTTTGTTGTGGGTTTTGT
GGATTAAATAGGGAAATTAA

Downstream 100 bases:

>100_bases
TTGATTAATGCATTAGATTGATATAATAAAGCCTTGAGGTAGTGATACCTCAAGGCTTTTTGTTATGTCTATTTCAGTAT
TTAAATACTCGTATTGTAGT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MTTQKSKIIYTITDEAPALATHSLLPIIQAFAASSDIDVDTRDISLAGRVIANFPEYLTEDQRIGDALAELGELAKTPEA
NIIKLPNISASIPQLHAVIKELQAKGYALPNYPEEAKTDEEKAVKAVYDKIKGSAVNPVLREGNSDRRAPGAVKQYARNN
PHSMGAWSSDSKSHVASMSDGDFYSSEQSVTIDGATNVSIEFVAENGDITVLKEGLALQDKEIIDGSRLSKKALVEFFDA
ETKKAKEEDVLLSLHMKATMMKVSDPVIFGHAVKVFYKDVFEKHAATFEKLGVDANNGIGDVYSKIASLPEAEKSQIEAD
LAAVYEYQPELAMVDSDRGITNLHVPSDVIIDASMPAALRTSGQMWGPDGQLKDTKAMIPDRCYAGVYQAVIDFCKANGA
FDPTTMGSVPNVGLMAQKAEEYGSHDKTFILPAAGTVRVIDGAGHALIEHAVAEGDIWRMCQAKDAPIQDWVKLAVNRAR
ATGTPAVFWLDANRSHDAELIKKVNTYLADHDTTGLDIRILAPVEATQFSLERIVKGENTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENHLRWDSLGEFLALAASFEHLSVTTGNAKAQILADTLDAATS
KFLETNKSPSRRVGELDNRGSHFYLAMYWAQELAAQTKDAELQTYFGSLAETLTSNEAKIVDELNAAQGVAGNVGGYFQP
VAELAAKEMRPSATLNAALSSL

Sequences:

>Translated_742_residues
MTTQKSKIIYTITDEAPALATHSLLPIIQAFAASSDIDVDTRDISLAGRVIANFPEYLTEDQRIGDALAELGELAKTPEA
NIIKLPNISASIPQLHAVIKELQAKGYALPNYPEEAKTDEEKAVKAVYDKIKGSAVNPVLREGNSDRRAPGAVKQYARNN
PHSMGAWSSDSKSHVASMSDGDFYSSEQSVTIDGATNVSIEFVAENGDITVLKEGLALQDKEIIDGSRLSKKALVEFFDA
ETKKAKEEDVLLSLHMKATMMKVSDPVIFGHAVKVFYKDVFEKHAATFEKLGVDANNGIGDVYSKIASLPEAEKSQIEAD
LAAVYEYQPELAMVDSDRGITNLHVPSDVIIDASMPAALRTSGQMWGPDGQLKDTKAMIPDRCYAGVYQAVIDFCKANGA
FDPTTMGSVPNVGLMAQKAEEYGSHDKTFILPAAGTVRVIDGAGHALIEHAVAEGDIWRMCQAKDAPIQDWVKLAVNRAR
ATGTPAVFWLDANRSHDAELIKKVNTYLADHDTTGLDIRILAPVEATQFSLERIVKGENTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENHLRWDSLGEFLALAASFEHLSVTTGNAKAQILADTLDAATS
KFLETNKSPSRRVGELDNRGSHFYLAMYWAQELAAQTKDAELQTYFGSLAETLTSNEAKIVDELNAAQGVAGNVGGYFQP
VAELAAKEMRPSATLNAALSSL
>Mature_741_residues
TTQKSKIIYTITDEAPALATHSLLPIIQAFAASSDIDVDTRDISLAGRVIANFPEYLTEDQRIGDALAELGELAKTPEAN
IIKLPNISASIPQLHAVIKELQAKGYALPNYPEEAKTDEEKAVKAVYDKIKGSAVNPVLREGNSDRRAPGAVKQYARNNP
HSMGAWSSDSKSHVASMSDGDFYSSEQSVTIDGATNVSIEFVAENGDITVLKEGLALQDKEIIDGSRLSKKALVEFFDAE
TKKAKEEDVLLSLHMKATMMKVSDPVIFGHAVKVFYKDVFEKHAATFEKLGVDANNGIGDVYSKIASLPEAEKSQIEADL
AAVYEYQPELAMVDSDRGITNLHVPSDVIIDASMPAALRTSGQMWGPDGQLKDTKAMIPDRCYAGVYQAVIDFCKANGAF
DPTTMGSVPNVGLMAQKAEEYGSHDKTFILPAAGTVRVIDGAGHALIEHAVAEGDIWRMCQAKDAPIQDWVKLAVNRARA
TGTPAVFWLDANRSHDAELIKKVNTYLADHDTTGLDIRILAPVEATQFSLERIVKGENTISVTGNVLRDYLTDLFPILEL
GTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENHLRWDSLGEFLALAASFEHLSVTTGNAKAQILADTLDAATSK
FLETNKSPSRRVGELDNRGSHFYLAMYWAQELAAQTKDAELQTYFGSLAETLTSNEAKIVDELNAAQGVAGNVGGYFQPV
AELAAKEMRPSATLNAALSSL

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 80185; Mature: 80054

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQKSKIIYTITDEAPALATHSLLPIIQAFAASSDIDVDTRDISLAGRVIANFPEYLTE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHCC
DQRIGDALAELGELAKTPEANIIKLPNISASIPQLHAVIKELQAKGYALPNYPEEAKTDE
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAVKAVYDKIKGSAVNPVLREGNSDRRAPGAVKQYARNNPHSMGAWSSDSKSHVASMSD
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
GDFYSSEQSVTIDGATNVSIEFVAENGDITVLKEGLALQDKEIIDGSRLSKKALVEFFDA
CCCCCCCCCEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHH
ETKKAKEEDVLLSLHMKATMMKVSDPVIFGHAVKVFYKDVFEKHAATFEKLGVDANNGIG
HHHCCCCCCEEEEEHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYSKIASLPEAEKSQIEADLAAVYEYQPELAMVDSDRGITNLHVPSDVIIDASMPAALR
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCHHHH
TSGQMWGPDGQLKDTKAMIPDRCYAGVYQAVIDFCKANGAFDPTTMGSVPNVGLMAQKAE
CCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFILPAAGTVRVIDGAGHALIEHAVAEGDIWRMCQAKDAPIQDWVKLAVNRAR
HHCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHC
ATGTPAVFWLDANRSHDAELIKKVNTYLADHDTTGLDIRILAPVEATQFSLERIVKGENT
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENH
EEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALAASFEHLSVTTGNAKAQILADTLDAATSKFLETNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
SHFYLAMYWAQELAAQTKDAELQTYFGSLAETLTSNEAKIVDELNAAQGVAGNVGGYFQP
CEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHH
VAELAAKEMRPSATLNAALSSL
HHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
TTQKSKIIYTITDEAPALATHSLLPIIQAFAASSDIDVDTRDISLAGRVIANFPEYLTE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHCC
DQRIGDALAELGELAKTPEANIIKLPNISASIPQLHAVIKELQAKGYALPNYPEEAKTDE
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAVKAVYDKIKGSAVNPVLREGNSDRRAPGAVKQYARNNPHSMGAWSSDSKSHVASMSD
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
GDFYSSEQSVTIDGATNVSIEFVAENGDITVLKEGLALQDKEIIDGSRLSKKALVEFFDA
CCCCCCCCCEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHH
ETKKAKEEDVLLSLHMKATMMKVSDPVIFGHAVKVFYKDVFEKHAATFEKLGVDANNGIG
HHHCCCCCCEEEEEHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYSKIASLPEAEKSQIEADLAAVYEYQPELAMVDSDRGITNLHVPSDVIIDASMPAALR
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCHHHH
TSGQMWGPDGQLKDTKAMIPDRCYAGVYQAVIDFCKANGAFDPTTMGSVPNVGLMAQKAE
CCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFILPAAGTVRVIDGAGHALIEHAVAEGDIWRMCQAKDAPIQDWVKLAVNRAR
HHCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHC
ATGTPAVFWLDANRSHDAELIKKVNTYLADHDTTGLDIRILAPVEATQFSLERIVKGENT
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEKENH
EEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALAASFEHLSVTTGNAKAQILADTLDAATSKFLETNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
SHFYLAMYWAQELAAQTKDAELQTYFGSLAETLTSNEAKIVDELNAAQGVAGNVGGYFQP
CEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHH
VAELAAKEMRPSATLNAALSSL
HHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]