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The map label for this gene is fadR [H]

Identifier: 59712240

GI number: 59712240

Start: 1835905

End: 1836747

Strand: Reverse

Name: fadR [H]

Synonym: VF_1633

Alternate gene names: 59712240

Gene position: 1836747-1835905 (Counterclockwise)

Preceding gene: 59712243

Following gene: 59712239

Centisome position: 63.39

GC content: 35.47

Gene sequence:

>843_bases
ATGGTTATTAAGGCAAAAAGTCCTGCAGCATTCGCTGAAAAGTACATTATTGAAAGTATTTGGAATGGTCGTTTCCCACC
AGGCTCAATTTTACCAGCTGAGCGAGAGCTTTCTGAATTAATCGGTGTAACGAGAACGACATTACGAGAAGTATTACAAC
GTTTAGCTCGTGATGGTTGGTTGACAATTCAACATGGTAAACCAACAAAAGTGAACAATTATATGGAAACCTCAGGTTTG
CATATTTTAGATACATTAATGACATTAGTTGATGCAAATAATGCCACTTCAATTGTTGAAGACTTATTGGCTGCTCGAAC
TAACATTAGTTGTATTTTCATGAGACAAGCATTCAAGACAAATAAAGAAGGCTCTTTAAGAACTCTTAATCGTGTTATTG
AATCGTGTGAACAGTTACTTGCTGCAGAAAGTTGGGATAGTTTCATAGAAGCATCCCCATTCGGAGCAAAAATTAAAGCT
GAAGTGAAAGAAGATAACGAAAAAGATCCTGTCAAACGTGAAGAGATCTTGATTGCTAAAACCTTCAACTATTATGATTA
TATGCTTTTCCAAGGTGTTGCTTTTAAATCTGGCAATCAAATTTATGGGCTTATCTTTAATGGTTTGAAAAAGCTTTATG
CGCGAGTTGGTAGTTACTACTTCTCTAACTCTGAAGCTCGAGAGTTAGCTTTACAATTTTATCGTGACTTAAAGCTTATT
TGCGAAGAAGAACGTAAAGATGCTGTAATGCCTAGAATGCGCCAATACGGTATGGAAGGTAATTTGATTTGGAATGAAAT
GAAATTAAATTTACCAAGCAACTTTAGAGAAGATGATAGTTAA

Upstream 100 bases:

>100_bases
TTCTAAATTACAGGTAAATTTAATAAATAGTTAAGGATTTATTGAACTGGTGGTATGATGAGTGCAGTTATCTTATTTAA
AGAACGGATTTTAAACTTGT

Downstream 100 bases:

>100_bases
TCCGATTTAAAATTGAATAAAGCAGGCACTTAGCCTGCTTTTTTTATATCTAAAATAAACAAAAAACCTAAATAACTATG
AAATGGCGTGTGATTATGTA

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MVIKAKSPAAFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNYMETSGL
HILDTLMTLVDANNATSIVEDLLAARTNISCIFMRQAFKTNKEGSLRTLNRVIESCEQLLAAESWDSFIEASPFGAKIKA
EVKEDNEKDPVKREEILIAKTFNYYDYMLFQGVAFKSGNQIYGLIFNGLKKLYARVGSYYFSNSEARELALQFYRDLKLI
CEEERKDAVMPRMRQYGMEGNLIWNEMKLNLPSNFREDDS

Sequences:

>Translated_280_residues
MVIKAKSPAAFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNYMETSGL
HILDTLMTLVDANNATSIVEDLLAARTNISCIFMRQAFKTNKEGSLRTLNRVIESCEQLLAAESWDSFIEASPFGAKIKA
EVKEDNEKDPVKREEILIAKTFNYYDYMLFQGVAFKSGNQIYGLIFNGLKKLYARVGSYYFSNSEARELALQFYRDLKLI
CEEERKDAVMPRMRQYGMEGNLIWNEMKLNLPSNFREDDS
>Mature_280_residues
MVIKAKSPAAFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNYMETSGL
HILDTLMTLVDANNATSIVEDLLAARTNISCIFMRQAFKTNKEGSLRTLNRVIESCEQLLAAESWDSFIEASPFGAKIKA
EVKEDNEKDPVKREEILIAKTFNYYDYMLFQGVAFKSGNQIYGLIFNGLKKLYARVGSYYFSNSEARELALQFYRDLKLI
CEEERKDAVMPRMRQYGMEGNLIWNEMKLNLPSNFREDDS

Specific function: Multifunctional regulator of fatty acid metabolism [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=275, Percent_Identity=52.3636363636364, Blast_Score=275, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07840 FadR_C; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 32095; Mature: 32095

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKAKSPAAFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTIQHGKPTKVNNYMETSGLHILDTLMTLVDANNATSIVEDLLAARTNISCIFMRQAFKT
EEEECCCCCCCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHEEEHHHHCC
NKEGSLRTLNRVIESCEQLLAAESWDSFIEASPFGAKIKAEVKEDNEKDPVKREEILIAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCHHHEEEEE
TFNYYDYMLFQGVAFKSGNQIYGLIFNGLKKLYARVGSYYFSNSEARELALQFYRDLKLI
HHCHHHHHHHHCCEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
CEEERKDAVMPRMRQYGMEGNLIWNEMKLNLPSNFREDDS
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVIKAKSPAAFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTIQHGKPTKVNNYMETSGLHILDTLMTLVDANNATSIVEDLLAARTNISCIFMRQAFKT
EEEECCCCCCCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHEEEHHHHCC
NKEGSLRTLNRVIESCEQLLAAESWDSFIEASPFGAKIKAEVKEDNEKDPVKREEILIAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCHHHEEEEE
TFNYYDYMLFQGVAFKSGNQIYGLIFNGLKKLYARVGSYYFSNSEARELALQFYRDLKLI
HHCHHHHHHHHCCEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
CEEERKDAVMPRMRQYGMEGNLIWNEMKLNLPSNFREDDS
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA