Click here to switch to the map view.

The map label for this gene is mdtA [H]

Identifier: 59712189

GI number: 59712189

Start: 1771668

End: 1772714

Strand: Reverse

Name: mdtA [H]

Synonym: VF_1582

Alternate gene names: 59712189

Gene position: 1772714-1771668 (Counterclockwise)

Preceding gene: 59712192

Following gene: 59712188

Centisome position: 61.18

GC content: 38.2

Gene sequence:

>1047_bases
ATGAATAAAACTAAGTCTATCGCTCTTGTTGTTTTATTAGCATGCACTTTATCAACTCCTTCTTATGCTAAGAAAACAAG
AGGAAATCAGTCGGTTGCTGTTCTTTCTGAAGAAGTGGCTACTCATGAAATATCTCAATCATTATCATTAATCGGAAAAC
TAAAAGCTTCTGAGTCTGTTGTGATCTCTCCTGAGGTTGCAGGAAAGATTGAGCGTATTGCAGTTAAAGCGAACCAGAAC
GTAAGAAAAGGGCAGTTAGTTGTTCAACTTAATGACGATAAGGCAATTGCGGCTATTAAAGAGGCTCGTGCTTATTTAAA
TGATGAAAAACGTAAATTAACTGAATTTCAGCGTTTAGCGAAAAAGAATGCCATTACTCAAACTGAAATTGATGGACAAA
AAGCCAGCGTTGATATTGCTCAAGCTCGTTTAGATGCAGCTAATGCAGATTTATCTGATCTTCATATCTCTGCTCCTTTT
GCTGGTACGGTTGGTTTTATTGATTTTAGCCGAGGCAAAATGGTGAGTGCCGGTACGGAGCTGCTAACCTTAGATAATTT
ATCTGTTATGCAGCTTGATTTACAAGTGCCGGAACGTTATCTATCAATGCTTTCTGTTGGTATGAATGTAGAAGCAACGA
GTCAAGCGTGGAAAAACTCAGTGTTTTCAGGAAAACTGATAGGTGTTGATTCACGAATTAATGCAGAAACGTTGAATTTA
CGTGTTCGTATTGAATTCCCTAATAAAGATCTGAAAATGAAACCGGGAATGCTGATGGCTGCGACGTTAGATTTCCCTGC
TATTAATGCACCTATTATTCCTGTTCAAGCTTTAGAGTACTCTGGTACTAAGCGTTATGTGTATGTTGTAGGTGAAGATA
ACAAAGCAATTCGCACCGAAGTTACTTTAGGCGCTCGTGTTGAAAACCGTGTTGTCATCGCTAGTGGTTTAAATGTAGGT
GATGAAATTGTAGTTCAAGGTTTAGTTAACATGCGTGATGGTGTGACGGTTAAACAACTTGAACAAAATAAAACTGAGGT
ACAGTAA

Upstream 100 bases:

>100_bases
TTATTTCGTCATCTTTACATTCATTGACGAACCAAAGGTCTTTTACCTTGGTAAACTATGACCAGAAATTAATTCCATCA
TTTAGATTATAAGTATCAAT

Downstream 100 bases:

>100_bases
TCATGTGGTTATCTGATGTTTCAGTAAAAAGACCAGTGGTAGCCATTGTTTTAAGTTTGCTGTTGTGTGTATTTGGTGCG
GTGTCGTTCAGTAAATTGGC

Product: periplasmic component of efflux system

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNKTKSIALVVLLACTLSTPSYAKKTRGNQSVAVLSEEVATHEISQSLSLIGKLKASESVVISPEVAGKIERIAVKANQN
VRKGQLVVQLNDDKAIAAIKEARAYLNDEKRKLTEFQRLAKKNAITQTEIDGQKASVDIAQARLDAANADLSDLHISAPF
AGTVGFIDFSRGKMVSAGTELLTLDNLSVMQLDLQVPERYLSMLSVGMNVEATSQAWKNSVFSGKLIGVDSRINAETLNL
RVRIEFPNKDLKMKPGMLMAATLDFPAINAPIIPVQALEYSGTKRYVYVVGEDNKAIRTEVTLGARVENRVVIASGLNVG
DEIVVQGLVNMRDGVTVKQLEQNKTEVQ

Sequences:

>Translated_348_residues
MNKTKSIALVVLLACTLSTPSYAKKTRGNQSVAVLSEEVATHEISQSLSLIGKLKASESVVISPEVAGKIERIAVKANQN
VRKGQLVVQLNDDKAIAAIKEARAYLNDEKRKLTEFQRLAKKNAITQTEIDGQKASVDIAQARLDAANADLSDLHISAPF
AGTVGFIDFSRGKMVSAGTELLTLDNLSVMQLDLQVPERYLSMLSVGMNVEATSQAWKNSVFSGKLIGVDSRINAETLNL
RVRIEFPNKDLKMKPGMLMAATLDFPAINAPIIPVQALEYSGTKRYVYVVGEDNKAIRTEVTLGARVENRVVIASGLNVG
DEIVVQGLVNMRDGVTVKQLEQNKTEVQ
>Mature_348_residues
MNKTKSIALVVLLACTLSTPSYAKKTRGNQSVAVLSEEVATHEISQSLSLIGKLKASESVVISPEVAGKIERIAVKANQN
VRKGQLVVQLNDDKAIAAIKEARAYLNDEKRKLTEFQRLAKKNAITQTEIDGQKASVDIAQARLDAANADLSDLHISAPF
AGTVGFIDFSRGKMVSAGTELLTLDNLSVMQLDLQVPERYLSMLSVGMNVEATSQAWKNSVFSGKLIGVDSRINAETLNL
RVRIEFPNKDLKMKPGMLMAATLDFPAINAPIIPVQALEYSGTKRYVYVVGEDNKAIRTEVTLGARVENRVVIASGLNVG
DEIVVQGLVNMRDGVTVKQLEQNKTEVQ

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=347, Percent_Identity=25.0720461095101, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081796, Length=319, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786668, Length=383, Percent_Identity=24.8041775456919, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789665, Length=323, Percent_Identity=24.4582043343653, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789929, Length=383, Percent_Identity=22.7154046997389, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37807; Mature: 37807

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTKSIALVVLLACTLSTPSYAKKTRGNQSVAVLSEEVATHEISQSLSLIGKLKASESV
CCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
VISPEVAGKIERIAVKANQNVRKGQLVVQLNDDKAIAAIKEARAYLNDEKRKLTEFQRLA
EECCHHHCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
KKNAITQTEIDGQKASVDIAQARLDAANADLSDLHISAPFAGTVGFIDFSRGKMVSAGTE
HHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCEEEECCCE
LLTLDNLSVMQLDLQVPERYLSMLSVGMNVEATSQAWKNSVFSGKLIGVDSRINAETLNL
EEEECCCEEEEEEHHCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEE
RVRIEFPNKDLKMKPGMLMAATLDFPAINAPIIPVQALEYSGTKRYVYVVGEDNKAIRTE
EEEEECCCCCCEECCCEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEE
VTLGARVENRVVIASGLNVGDEIVVQGLVNMRDGVTVKQLEQNKTEVQ
EEECCEECCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MNKTKSIALVVLLACTLSTPSYAKKTRGNQSVAVLSEEVATHEISQSLSLIGKLKASESV
CCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
VISPEVAGKIERIAVKANQNVRKGQLVVQLNDDKAIAAIKEARAYLNDEKRKLTEFQRLA
EECCHHHCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
KKNAITQTEIDGQKASVDIAQARLDAANADLSDLHISAPFAGTVGFIDFSRGKMVSAGTE
HHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCEEEECCCE
LLTLDNLSVMQLDLQVPERYLSMLSVGMNVEATSQAWKNSVFSGKLIGVDSRINAETLNL
EEEECCCEEEEEEHHCHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEE
RVRIEFPNKDLKMKPGMLMAATLDFPAINAPIIPVQALEYSGTKRYVYVVGEDNKAIRTE
EEEEECCCCCCEECCCEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEE
VTLGARVENRVVIASGLNVGDEIVVQGLVNMRDGVTVKQLEQNKTEVQ
EEECCEECCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]