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The map label for this gene is cysG [H]

Identifier: 59712138

GI number: 59712138

Start: 1712507

End: 1713448

Strand: Reverse

Name: cysG [H]

Synonym: VF_1531

Alternate gene names: 59712138

Gene position: 1713448-1712507 (Counterclockwise)

Preceding gene: 59712144

Following gene: 59712137

Centisome position: 59.13

GC content: 36.52

Gene sequence:

>942_bases
ATGAGATATTTTCCCATGTTTATGGATATTAAAAAGCGACCAGTATTGGTTGTTGGTGGTGGTGAAGTAGCCTGTCGTAA
GATAGATATGTTGCTGCAAGCTGAGGCAAGTATTACCGTTGTCGCACCATCAATTAAAGCTTATTTAATGAAATACGTAG
AAGAAGGGAAGCTTGAATATATAAAGGGTTTTTATCATAAAAACTTATTAAGTAATGATTACGTACAAGTATGGGCAACA
ACAGACAATTCAGATTTAAATCACCAAGTACATGCTGATGCGCATGACGTTGGCGTTCCGGTGAATGTTGTTGATGATAC
GGAATATTGTGATTTTATAACGCCATCAATGGTCAATCGAGGTCGTGTTCAGGTCGCTATTTCAAGTGGTGGAGCATCTC
CGGTATTAATCCGAATTATTAGAGAACAGCTTGAAACTCAGCTATCAACAAAAGTTGCCATGTTAGCGGACTTTGGTGCT
GATAAGCGAAATCTTATTAAACAGCATTTTAAAACTGTTGATGAGAGAAGAAAATTTTGGGAAACCTTTTTGCGATTGCC
CGAAATCGAGAAGATAAATACTCGAAATGAATTAGAAGCATTATTTCAACAAGCATTAACGACTGATGTTCAAATTAAGT
CTGAACGGAATTGGATTGAGTATAATTCGGATACTGAAATGCTGACTCTAAAAGCACTGCGATTAATGCAGCAAGCAGAA
TGGGTTATTGCTTTTGAAAGTTGTCCTGCTGAATTCATTGAGCTTTGTCGTCGTGATGCGGAGCGTATTTATATTCGTTC
TGAAAAAGAGATGGCGGATTATTTGGATAAAGCAAACGCTGAAAACATCCGAGTGACTATTTTAGTGAAAAAAGGTCAAT
TATTCAGTGATTCAAATATTCAGCATTATTTAGCAAATGATGTATATGTTCCTACATTATAG

Upstream 100 bases:

>100_bases
TAACTAAACAATCATGGTTTACTGAATGCATACCTTATTTTTTAAAATCAAGGTATATTAAAGCTGTATATTCAAAGAGA
TATTAAGGAAGCGGATTGTA

Downstream 100 bases:

>100_bases
GTTTATTAATGCAGTATTTAACGATTAAAGATGCAATAGAAGAGCAAATTGATACTGGCATGTTTGAGGCTGGACAAAAG
TTGCCTTCAGAAAGAACGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MRYFPMFMDIKKRPVLVVGGGEVACRKIDMLLQAEASITVVAPSIKAYLMKYVEEGKLEYIKGFYHKNLLSNDYVQVWAT
TDNSDLNHQVHADAHDVGVPVNVVDDTEYCDFITPSMVNRGRVQVAISSGGASPVLIRIIREQLETQLSTKVAMLADFGA
DKRNLIKQHFKTVDERRKFWETFLRLPEIEKINTRNELEALFQQALTTDVQIKSERNWIEYNSDTEMLTLKALRLMQQAE
WVIAFESCPAEFIELCRRDAERIYIRSEKEMADYLDKANAENIRVTILVKKGQLFSDSNIQHYLANDVYVPTL

Sequences:

>Translated_313_residues
MRYFPMFMDIKKRPVLVVGGGEVACRKIDMLLQAEASITVVAPSIKAYLMKYVEEGKLEYIKGFYHKNLLSNDYVQVWAT
TDNSDLNHQVHADAHDVGVPVNVVDDTEYCDFITPSMVNRGRVQVAISSGGASPVLIRIIREQLETQLSTKVAMLADFGA
DKRNLIKQHFKTVDERRKFWETFLRLPEIEKINTRNELEALFQQALTTDVQIKSERNWIEYNSDTEMLTLKALRLMQQAE
WVIAFESCPAEFIELCRRDAERIYIRSEKEMADYLDKANAENIRVTILVKKGQLFSDSNIQHYLANDVYVPTL
>Mature_313_residues
MRYFPMFMDIKKRPVLVVGGGEVACRKIDMLLQAEASITVVAPSIKAYLMKYVEEGKLEYIKGFYHKNLLSNDYVQVWAT
TDNSDLNHQVHADAHDVGVPVNVVDDTEYCDFITPSMVNRGRVQVAISSGGASPVLIRIIREQLETQLSTKVAMLADFGA
DKRNLIKQHFKTVDERRKFWETFLRLPEIEKINTRNELEALFQQALTTDVQIKSERNWIEYNSDTEMLTLKALRLMQQAE
WVIAFESCPAEFIELCRRDAERIYIRSEKEMADYLDKANAENIRVTILVKKGQLFSDSNIQHYLANDVYVPTL

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=269, Percent_Identity=33.457249070632, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 36067; Mature: 36067

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFPMFMDIKKRPVLVVGGGEVACRKIDMLLQAEASITVVAPSIKAYLMKYVEEGKLEY
CCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCHHH
IKGFYHKNLLSNDYVQVWATTDNSDLNHQVHADAHDVGVPVNVVDDTEYCDFITPSMVNR
HHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCHHCCCCEEEECCCCHHCCCCHHHCCC
GRVQVAISSGGASPVLIRIIREQLETQLSTKVAMLADFGADKRNLIKQHFKTVDERRKFW
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ETFLRLPEIEKINTRNELEALFQQALTTDVQIKSERNWIEYNSDTEMLTLKALRLMQQAE
HHHHCCCCCHHCCCHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHCC
WVIAFESCPAEFIELCRRDAERIYIRSEKEMADYLDKANAENIRVTILVKKGQLFSDSNI
EEEEECCCCHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
QHYLANDVYVPTL
HHHHCCCEEECCC
>Mature Secondary Structure
MRYFPMFMDIKKRPVLVVGGGEVACRKIDMLLQAEASITVVAPSIKAYLMKYVEEGKLEY
CCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCHHH
IKGFYHKNLLSNDYVQVWATTDNSDLNHQVHADAHDVGVPVNVVDDTEYCDFITPSMVNR
HHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCHHCCCCEEEECCCCHHCCCCHHHCCC
GRVQVAISSGGASPVLIRIIREQLETQLSTKVAMLADFGADKRNLIKQHFKTVDERRKFW
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ETFLRLPEIEKINTRNELEALFQQALTTDVQIKSERNWIEYNSDTEMLTLKALRLMQQAE
HHHHCCCCCHHCCCHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHCC
WVIAFESCPAEFIELCRRDAERIYIRSEKEMADYLDKANAENIRVTILVKKGQLFSDSNI
EEEEECCCCHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
QHYLANDVYVPTL
HHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA