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The map label for this gene is hscA [H]

Identifier: 59712124

GI number: 59712124

Start: 1692360

End: 1694180

Strand: Direct

Name: hscA [H]

Synonym: VF_1517

Alternate gene names: 59712124

Gene position: 1692360-1694180 (Clockwise)

Preceding gene: 59712123

Following gene: 59712125

Centisome position: 58.41

GC content: 43.05

Gene sequence:

>1821_bases
ATGGAACAAGCTAAATACAGCATTGGTATCGATTTAGGTACAACTCACTGTGTACTTTCATACGTTGATTTACATGATGA
AGACGCAAGCGTTCAAGTAATGCCAATCCCTCAACTCACCGCTCCAGGTCAAGTTGAAGAGAAATCGCAGCTGCCTTCTT
TCATGTATCAAGCACATGAAGCTGAACTATTAGAAGGTGATACAAGCCTTCCTTGGACAACCAAGCCAAACGCAATTGTT
GGTAGTATTGCCCGCAACCTTGGTAGTAAAACGCCAATTCGTTTGATTGCAAGTGCGAAAAGCTGGTTATGTCACGGTGG
CGTAAACCGTCGTGAAGCATTCTTACCACTAAACAGCCCAGAAGAAGTGATCAAAGCATCGCCTCTTGAAGTAACAAAAC
GTTATTTAGAGCATTTACAAAACGCTTGGGATCACCAAAATCCAGAGCACCCTCTAAATGAACAAGACATTACAATTACG
GTACCTGCATCATTTGACCCTGCTGCTCGTGATTTAACAGCAGAAGCGGCAAATAATCTTGGTTTCCGTAACTTAACGCT
TTTAGAAGAACCACAAGCAGCAGTATACAGCTGGATCAAAAATAACGATGATTCATGGCGTGACCAAGTATCGGTTGGTG
ATGTTATTTTAGTTGTTGATATTGGTGGTGGTACAACGGATTTATCATTAGTTGCTGTTACTGAAGAAGAAGGTAATTTA
AGCCTAAACCGTGTTGCGGTAGGCGACCATATTCTTCTTGGTGGTGACAACATGGATTTAGCCCTAGCTTATCGCTTAAA
AATGAAGCTAGCGCAAGAAGGTAAGCAGTTACAACCTTGGCAAATTCAAGTGATGACACACGCTTGTCGTGATGCAAAAG
AAGCACTATTAAATGACTCAGAATTACGAGCAGTACCGATTGTGGTTCCTAGCCGTGGTTCTAAATTGTTAGGTGGCACG
CTACAAACGGAATTAACTCAAGAAGAAGTACAACAAACATTAGTTGAAGGCTTCTTCCCTGTAGTTCCTGTGACTGAGCA
CCCAGTTCAATCTGCACGTGGTGCATTAACTCAAATGGGTCTTCCTTATGCACAAGATGCAGCGGTAACTCGTCACCTTG
CTAGCTTCTTAACTCGTCAACAAGCAGCAACTGATGAAGTATTTGGTCAGCAAAACGAATCTGATTTTATTAAACCAACA
GCCATTCTTTTAAATGGTGGTGTTCTAAAATCAAACCTACTTGCAGAACGTCTACTTGGTATTATTAATCAGTGGTTAAT
CGATGGCGAAGCGGAAGATGCAAAACTTCTTGAAGGTCTTGACCTTGATTTAGCTGTTGCGGCTGGTGCTTCTTACTACG
GCTCTGTTCGTACCGGTAAAGGTGTTCGTATCCGTGGTGGTATTGCATCAAGCTACTATGTTGGTATCGAAAGCTCTATG
CCTGCGATTCCTGGAATGGAACCACCAATGGAAGCATTATGTGTTGCTCCATTTGGTATGGAAGAAGGCTCGCACGCCGA
TGTACCTAGCCAACAATTTGGTTTGGTGATTGGCCAACCGGTGCAATTTAAGTTCTATGGTTCAACGACTCGTCGTGATG
ACCAAGCCGGTACACATTTGGATTTCTGGATGCCTGAAGAGCTAGAAGAATTACCTACAATTCAAGTAACTCTACCTGTA
ACGGAAGGACGTACCGCAGGTGAAGTGGTTCCTGTTCGTTTAGCGTCTAAAGTAACAGAGCTTGGTACTCTATATCTTGA
AGCGATTGCTGCAGATAGTGGTGAGAAATGGCACGTTGAGTTTGATGTTCGTGAAGCGTAA

Upstream 100 bases:

>100_bases
CATTAATTCACCGTGGTTGGAAAGTAGCAGAAGTGAAGCTACCAAAGCTGGCTGAAGGTTATGACGCAACAATCGTTGCT
CCAGCAGAGGTTGAACTGTA

Downstream 100 bases:

>100_bases
TTTGGATATTATTCTTCGCTAGTTACGTATCTTAAGAGTTCAGTCACCGTTATGGAGTCTGAACTCTTTTACTATATATC
CTTTGTATTTTTGCTGTTGC

Product: DnaK-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MEQAKYSIGIDLGTTHCVLSYVDLHDEDASVQVMPIPQLTAPGQVEEKSQLPSFMYQAHEAELLEGDTSLPWTTKPNAIV
GSIARNLGSKTPIRLIASAKSWLCHGGVNRREAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDHQNPEHPLNEQDITIT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNDDSWRDQVSVGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRAVPIVVPSRGSKLLGGT
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDEVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINQWLIDGEAEDAKLLEGLDLDLAVAAGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSHADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELEELPTIQVTLPV
TEGRTAGEVVPVRLASKVTELGTLYLEAIAADSGEKWHVEFDVREA

Sequences:

>Translated_606_residues
MEQAKYSIGIDLGTTHCVLSYVDLHDEDASVQVMPIPQLTAPGQVEEKSQLPSFMYQAHEAELLEGDTSLPWTTKPNAIV
GSIARNLGSKTPIRLIASAKSWLCHGGVNRREAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDHQNPEHPLNEQDITIT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNDDSWRDQVSVGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRAVPIVVPSRGSKLLGGT
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDEVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINQWLIDGEAEDAKLLEGLDLDLAVAAGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSHADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELEELPTIQVTLPV
TEGRTAGEVVPVRLASKVTELGTLYLEAIAADSGEKWHVEFDVREA
>Mature_606_residues
MEQAKYSIGIDLGTTHCVLSYVDLHDEDASVQVMPIPQLTAPGQVEEKSQLPSFMYQAHEAELLEGDTSLPWTTKPNAIV
GSIARNLGSKTPIRLIASAKSWLCHGGVNRREAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDHQNPEHPLNEQDITIT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNDDSWRDQVSVGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRAVPIVVPSRGSKLLGGT
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDEVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINQWLIDGEAEDAKLLEGLDLDLAVAAGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSHADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELEELPTIQVTLPV
TEGRTAGEVVPVRLASKVTELGTLYLEAIAADSGEKWHVEFDVREA

Specific function: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by hscB [H]

COG id: COG0443

COG function: function code O; Molecular chaperone

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 70 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17534015, Length=303, Percent_Identity=25.7425742574257, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17534013, Length=303, Percent_Identity=25.7425742574257, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 320 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 500 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stati

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018181
- InterPro:   IPR001023
- InterPro:   IPR013126
- InterPro:   IPR010236 [H]

Pfam domain/function: PF00012 HSP70 [H]

EC number: NA

Molecular weight: Translated: 65991; Mature: 65991

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00297 HSP70_1 ; PS00329 HSP70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAKYSIGIDLGTTHCVLSYVDLHDEDASVQVMPIPQLTAPGQVEEKSQLPSFMYQAHE
CCCCCEEEEEECCCHHHEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHCHHHHHHHHH
AELLEGDTSLPWTTKPNAIVGSIARNLGSKTPIRLIASAKSWLCHGGVNRREAFLPLNSP
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCEEEECCCCH
EEVIKASPLEVTKRYLEHLQNAWDHQNPEHPLNEQDITITVPASFDPAARDLTAEAANNL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC
GFRNLTLLEEPQAAVYSWIKNNDDSWRDQVSVGDVILVVDIGGGTTDLSLVAVTEEEGNL
CCCEEEEECCCHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCE
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDS
EEEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCC
ELRAVPIVVPSRGSKLLGGTLQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMG
CCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC
LPYAQDAAVTRHLASFLTRQQAATDEVFGQQNESDFIKPTAILLNGGVLKSNLLAERLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
IINQWLIDGEAEDAKLLEGLDLDLAVAAGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
HHHHHHCCCCCCHHHHHCCCCCEEEEECCCHHCCCCCCCCCEEEECCCCCEEEEEECCCC
PAIPGMEPPMEALCVAPFGMEEGSHADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHL
CCCCCCCCCHHHEEECCCCCCCCCCCCCCCHHCCEEECCCEEEEEECCCCCCCCCCCCEE
DFWMPEELEELPTIQVTLPVTEGRTAGEVVPVRLASKVTELGTLYLEAIAADSGEKWHVE
ECCCCHHHHHCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
FDVREA
EEEECC
>Mature Secondary Structure
MEQAKYSIGIDLGTTHCVLSYVDLHDEDASVQVMPIPQLTAPGQVEEKSQLPSFMYQAHE
CCCCCEEEEEECCCHHHEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHCHHHHHHHHH
AELLEGDTSLPWTTKPNAIVGSIARNLGSKTPIRLIASAKSWLCHGGVNRREAFLPLNSP
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCEEEECCCCH
EEVIKASPLEVTKRYLEHLQNAWDHQNPEHPLNEQDITITVPASFDPAARDLTAEAANNL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC
GFRNLTLLEEPQAAVYSWIKNNDDSWRDQVSVGDVILVVDIGGGTTDLSLVAVTEEEGNL
CCCEEEEECCCHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCE
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDS
EEEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCC
ELRAVPIVVPSRGSKLLGGTLQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMG
CCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC
LPYAQDAAVTRHLASFLTRQQAATDEVFGQQNESDFIKPTAILLNGGVLKSNLLAERLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
IINQWLIDGEAEDAKLLEGLDLDLAVAAGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
HHHHHHCCCCCCHHHHHCCCCCEEEEECCCHHCCCCCCCCCEEEECCCCCEEEEEECCCC
PAIPGMEPPMEALCVAPFGMEEGSHADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHL
CCCCCCCCCHHHEEECCCCCCCCCCCCCCCHHCCEEECCCEEEEEECCCCCCCCCCCCEE
DFWMPEELEELPTIQVTLPVTEGRTAGEVVPVRLASKVTELGTLYLEAIAADSGEKWHVE
ECCCCHHHHHCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
FDVREA
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA