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The map label for this gene is atoC [H]

Identifier: 59712008

GI number: 59712008

Start: 1550548

End: 1551975

Strand: Reverse

Name: atoC [H]

Synonym: VF_1401

Alternate gene names: 59712008

Gene position: 1551975-1550548 (Counterclockwise)

Preceding gene: 59712015

Following gene: 59712007

Centisome position: 53.56

GC content: 39.15

Gene sequence:

>1428_bases
ATGGTTGTAAAATCAGATTGGAATGCGTTTTCAGTTCTTGTTGTTGATGATGAAATTGGTATGCAAACCATACTAAAAAA
AGCATTAAGTAAACAATTTGGACAAGTGCATACCGCAGGTACGATTGAAGAAGCAGAAGAAATTCGACAATCTCACCATC
TTGATTTAATCATTCTTGATATTAACTTACCAGGTCAAACAGGTTTAGAGTGGCAAGAAAGCATTGCATGTGATGCGCGT
AATTATGATGTGATTTTCATGACAGGTTATGCGGAGTTAGATACGGCGATTCAAGCACTTCGACTTGGCGCATCTGATTT
TATTTTAAAACCGTTTAATCTTGAAAACATGCTACAAGCAGTAAAACGATGCATGGATCGTCGTTTAGTTGAGCGAACAA
ACTTTGCTTTAAAAAGAGAAGTCGAGAAGAAGAATCCGATTGAGATCATCGGTAATGCAGAGAAAACGTTACAACTAAAG
AAAATGGTTGCTCAACTTGCTCCATCTAATGCAGCTGTATTAATTGAAGGTGAATCAGGAACAGGTAAAGAGTTAGTTGC
TCGTGGTTTGCACCAATTAAGTGAACGCAAAGGGCCGTTTGTACCATTAAACTGCGGGGCTATTGCTCCTGACTTACTTG
AAAGTGAATTGTTTGGGCATACTTCTGGTGCGTTTACTGGTGCTAAGAAAGGGCGTGAGGGTTTATTCAGAGTTGCGAAT
GGTGGGACACTGTTTTTAGATGAAATCGGTGAAATGCCAATTGGAATGCAATCATCGTTGCTGCGAGCGTTAGAGCAAAA
AGCCATTAGACCTGTAGGCTCTGAAAAAGAAATTCCTGTTGATGTTCGTATTGTTGCTGCTACTAACCGTAATTTATTAG
AAGAAGTGGAAAAAGGAAATTTCAGAAAAGATTTATTTTATCGTTTAAATGTTTTGACGGTTTCTCTACCAGCATTACGA
GAGCGAAAAGCGGATCTTGCATGTTTAACTGAGCATTTTTCTCAAATGATTGCGAGTGAAATGGGAGTAAAACCTGTGCA
TTGGGCTCATGAAGATATCGTCGCAATGGCAAATTACGATTGGCCGGGTAATATCCGTGAGCTTAAAAACATGATTGAAC
GCTGTATTTTATTAGGCAAACCACCTGTTGAACATTGGGCTGAACTACAAGGTGATGAGCCAATTCATCAAGACAATGAA
CAGAATAAAAATGATGACGCATCAAGGAATAAAGAAGGCGAGTGTACTTGTATGCCTATCTTAGATACTTACCCAGAAAA
ATGGACATTAAAAGAAGTGGAAAAATCACACATCATCACTGTCGTGGATCTTCATGATGGTAATAAATCTGCAGCTGCAA
GGCAGTTGGGGGTTGCTCGTAAAACTTTAGAGCGTAAGTTTAAAGAGTGGAGCGAAGAAAACGCATGA

Upstream 100 bases:

>100_bases
CAAAATGTCGCAATAGAAAGGATACATTTTGCGAATAACAGGTTAGAATAATTAGGACATTTTGACCCACATAACACTTT
AGATCTTATTAGGAATAAAT

Downstream 100 bases:

>100_bases
CGCTATCTCCGACGGTTTGGAAAAAACGCATTAAAACCATGGTGCGTTATCGCTTACTTTGGTTGAACTCGGTTCCATTA
TTCTTAACCTTACTCGCTCT

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVVKSDWNAFSVLVVDDEIGMQTILKKALSKQFGQVHTAGTIEEAEEIRQSHHLDLIILDINLPGQTGLEWQESIACDAR
NYDVIFMTGYAELDTAIQALRLGASDFILKPFNLENMLQAVKRCMDRRLVERTNFALKREVEKKNPIEIIGNAEKTLQLK
KMVAQLAPSNAAVLIEGESGTGKELVARGLHQLSERKGPFVPLNCGAIAPDLLESELFGHTSGAFTGAKKGREGLFRVAN
GGTLFLDEIGEMPIGMQSSLLRALEQKAIRPVGSEKEIPVDVRIVAATNRNLLEEVEKGNFRKDLFYRLNVLTVSLPALR
ERKADLACLTEHFSQMIASEMGVKPVHWAHEDIVAMANYDWPGNIRELKNMIERCILLGKPPVEHWAELQGDEPIHQDNE
QNKNDDASRNKEGECTCMPILDTYPEKWTLKEVEKSHIITVVDLHDGNKSAAARQLGVARKTLERKFKEWSEENA

Sequences:

>Translated_475_residues
MVVKSDWNAFSVLVVDDEIGMQTILKKALSKQFGQVHTAGTIEEAEEIRQSHHLDLIILDINLPGQTGLEWQESIACDAR
NYDVIFMTGYAELDTAIQALRLGASDFILKPFNLENMLQAVKRCMDRRLVERTNFALKREVEKKNPIEIIGNAEKTLQLK
KMVAQLAPSNAAVLIEGESGTGKELVARGLHQLSERKGPFVPLNCGAIAPDLLESELFGHTSGAFTGAKKGREGLFRVAN
GGTLFLDEIGEMPIGMQSSLLRALEQKAIRPVGSEKEIPVDVRIVAATNRNLLEEVEKGNFRKDLFYRLNVLTVSLPALR
ERKADLACLTEHFSQMIASEMGVKPVHWAHEDIVAMANYDWPGNIRELKNMIERCILLGKPPVEHWAELQGDEPIHQDNE
QNKNDDASRNKEGECTCMPILDTYPEKWTLKEVEKSHIITVVDLHDGNKSAAARQLGVARKTLERKFKEWSEENA
>Mature_475_residues
MVVKSDWNAFSVLVVDDEIGMQTILKKALSKQFGQVHTAGTIEEAEEIRQSHHLDLIILDINLPGQTGLEWQESIACDAR
NYDVIFMTGYAELDTAIQALRLGASDFILKPFNLENMLQAVKRCMDRRLVERTNFALKREVEKKNPIEIIGNAEKTLQLK
KMVAQLAPSNAAVLIEGESGTGKELVARGLHQLSERKGPFVPLNCGAIAPDLLESELFGHTSGAFTGAKKGREGLFRVAN
GGTLFLDEIGEMPIGMQSSLLRALEQKAIRPVGSEKEIPVDVRIVAATNRNLLEEVEKGNFRKDLFYRLNVLTVSLPALR
ERKADLACLTEHFSQMIASEMGVKPVHWAHEDIVAMANYDWPGNIRELKNMIERCILLGKPPVEHWAELQGDEPIHQDNE
QNKNDDASRNKEGECTCMPILDTYPEKWTLKEVEKSHIITVVDLHDGNKSAAARQLGVARKTLERKFKEWSEENA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=470, Percent_Identity=38.0851063829787, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI1790437, Length=461, Percent_Identity=38.8286334056399, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1790299, Length=481, Percent_Identity=37.8378378378378, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=34, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789233, Length=340, Percent_Identity=39.4117647058824, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082117, Length=330, Percent_Identity=40.9090909090909, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786524, Length=335, Percent_Identity=40.8955223880597, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789087, Length=234, Percent_Identity=47.4358974358974, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082152, Length=249, Percent_Identity=45.3815261044177, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=46.3203463203463, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1787583, Length=324, Percent_Identity=38.5802469135802, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789828, Length=248, Percent_Identity=37.0967741935484, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=29.4670846394984, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53193; Mature: 53193

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKSDWNAFSVLVVDDEIGMQTILKKALSKQFGQVHTAGTIEEAEEIRQSHHLDLIILD
CEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEE
INLPGQTGLEWQESIACDARNYDVIFMTGYAELDTAIQALRLGASDFILKPFNLENMLQA
EECCCCCCCCHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEECCCCHHHHHHH
VKRCMDRRLVERTNFALKREVEKKNPIEIIGNAEKTLQLKKMVAQLAPSNAAVLIEGESG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCC
TGKELVARGLHQLSERKGPFVPLNCGAIAPDLLESELFGHTSGAFTGAKKGREGLFRVAN
CCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
GGTLFLDEIGEMPIGMQSSLLRALEQKAIRPVGSEKEIPVDVRIVAATNRNLLEEVEKGN
CCEEEEEHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCC
FRKDLFYRLNVLTVSLPALRERKADLACLTEHFSQMIASEMGVKPVHWAHEDIVAMANYD
CHHHHHHEEEHEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCC
WPGNIRELKNMIERCILLGKPPVEHWAELQGDEPIHQDNEQNKNDDASRNKEGECTCMPI
CCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEH
LDTYPEKWTLKEVEKSHIITVVDLHDGNKSAAARQLGVARKTLERKFKEWSEENA
HHCCCCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVVKSDWNAFSVLVVDDEIGMQTILKKALSKQFGQVHTAGTIEEAEEIRQSHHLDLIILD
CEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEE
INLPGQTGLEWQESIACDARNYDVIFMTGYAELDTAIQALRLGASDFILKPFNLENMLQA
EECCCCCCCCHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCEECCCCHHHHHHH
VKRCMDRRLVERTNFALKREVEKKNPIEIIGNAEKTLQLKKMVAQLAPSNAAVLIEGESG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCCC
TGKELVARGLHQLSERKGPFVPLNCGAIAPDLLESELFGHTSGAFTGAKKGREGLFRVAN
CCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
GGTLFLDEIGEMPIGMQSSLLRALEQKAIRPVGSEKEIPVDVRIVAATNRNLLEEVEKGN
CCEEEEEHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCC
FRKDLFYRLNVLTVSLPALRERKADLACLTEHFSQMIASEMGVKPVHWAHEDIVAMANYD
CHHHHHHEEEHEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCC
WPGNIRELKNMIERCILLGKPPVEHWAELQGDEPIHQDNEQNKNDDASRNKEGECTCMPI
CCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEH
LDTYPEKWTLKEVEKSHIITVVDLHDGNKSAAARQLGVARKTLERKFKEWSEENA
HHCCCCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]