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The map label for this gene is pheC [H]

Identifier: 59711877

GI number: 59711877

Start: 1410161

End: 1410925

Strand: Reverse

Name: pheC [H]

Synonym: VF_1270

Alternate gene names: 59711877

Gene position: 1410925-1410161 (Counterclockwise)

Preceding gene: 59711880

Following gene: 59711876

Centisome position: 48.69

GC content: 39.48

Gene sequence:

>765_bases
ATGATGAAAAAGAAACTTTTATGCATATCTGTGCTATTTGCCGCTTCCTTCACAGCTCACGCAGATCGCTTAGATGAAAT
CCAAGAAGCCGGAATTATTCGAGTCGGTACAACGGGTGACTATAAGCCCTTCTCTTCTTTCGATGGTAAGCAATTTTCTG
GTTATGATATTGATGTTGCCAAATACATAGCAGAACAGCTAGATGTAAAATTAGAGTTAGTTCAAACCTCATGGAAAAAT
CTCATTCCCGATCTTAATGCTGACAAATACGACATCGCAATGGGCGGCATCACACGTAAAATACAGCGTCAGCTGCATGC
TGAACAAAGCCAAGGCTACATGACTTTTGGTAAATGCTTCCTTGTCGCAAAAGGAAAAGCTGAAACTTATAACACCATTG
ATAAAGTCAATAAATCAAGTACTCGTTTAGGTATTAACATTGGCGGTACTAATGAGATATTTGCTGATACTCATCTACAA
AGTGCAACATTCACACGTTACAAAAATAACCTTGATGTTCCCCAAGCCGTTGCGACAGGAAAAGTTGACGTAATGGTAAC
CGAAACACCAGAAGCGCTTTACTACCAAGCAACAGACAAGCGATTAGAAGCGTCTCGCTGCGACGACCCATTCACAAAAA
GCCAATTTGGTTATTTAGTACCTAAAGGCGAGCAAGAGCTGCTAAATGCGGTTAACTTCATTATGGATGAAATGAAGCTA
AAAGGTGTAGATAAAGAATTAATGAAGAAAAATGCCTTGTTATAA

Upstream 100 bases:

>100_bases
TCACTCATGTTTTTTTATCGTTATTTATAGAATGGTTTAATCTGTTTATTTACAAAATAGTGATAAGTTTGTTAGTTAAA
TTAATAAACAAAAAGATTTG

Downstream 100 bases:

>100_bases
AGTAAGCAGTTAACGATATTTTTTATCTAATCACTTGCTATTTTATTCATTCACACCCAAAATAACGCTGTACTTATATA
CAGTGTTATTTTATGAATGT

Product: cyclohexadienyl dehydratase precursor

Products: NA

Alternate protein names: Prephenate dehydratase; Arogenate dehydratase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MMKKKLLCISVLFAASFTAHADRLDEIQEAGIIRVGTTGDYKPFSSFDGKQFSGYDIDVAKYIAEQLDVKLELVQTSWKN
LIPDLNADKYDIAMGGITRKIQRQLHAEQSQGYMTFGKCFLVAKGKAETYNTIDKVNKSSTRLGINIGGTNEIFADTHLQ
SATFTRYKNNLDVPQAVATGKVDVMVTETPEALYYQATDKRLEASRCDDPFTKSQFGYLVPKGEQELLNAVNFIMDEMKL
KGVDKELMKKNALL

Sequences:

>Translated_254_residues
MMKKKLLCISVLFAASFTAHADRLDEIQEAGIIRVGTTGDYKPFSSFDGKQFSGYDIDVAKYIAEQLDVKLELVQTSWKN
LIPDLNADKYDIAMGGITRKIQRQLHAEQSQGYMTFGKCFLVAKGKAETYNTIDKVNKSSTRLGINIGGTNEIFADTHLQ
SATFTRYKNNLDVPQAVATGKVDVMVTETPEALYYQATDKRLEASRCDDPFTKSQFGYLVPKGEQELLNAVNFIMDEMKL
KGVDKELMKKNALL
>Mature_254_residues
MMKKKLLCISVLFAASFTAHADRLDEIQEAGIIRVGTTGDYKPFSSFDGKQFSGYDIDVAKYIAEQLDVKLELVQTSWKN
LIPDLNADKYDIAMGGITRKIQRQLHAEQSQGYMTFGKCFLVAKGKAETYNTIDKVNKSSTRLGINIGGTNEIFADTHLQ
SATFTRYKNNLDVPQAVATGKVDVMVTETPEALYYQATDKRLEASRCDDPFTKSQFGYLVPKGEQELLNAVNFIMDEMKL
KGVDKELMKKNALL

Specific function: Forms alternative pathway for phenylalanine biosynthesis. Can catalyze two reactions:prephenate dehydratase and arogenate dehydratase. May have a role in chemotaxis or transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788228, Length=249, Percent_Identity=24.8995983935743, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787031, Length=251, Percent_Identity=25.0996015936255, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788649, Length=259, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787088, Length=255, Percent_Identity=23.1372549019608, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 1920 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1060 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 80 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015683
- InterPro:   IPR001638
- InterPro:   IPR018313 [H]

Pfam domain/function: PF00497 SBP_bac_3 [H]

EC number: =4.2.1.51; =4.2.1.91 [H]

Molecular weight: Translated: 28439; Mature: 28439

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKKLLCISVLFAASFTAHADRLDEIQEAGIIRVGTTGDYKPFSSFDGKQFSGYDIDVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
KYIAEQLDVKLELVQTSWKNLIPDLNADKYDIAMGGITRKIQRQLHAEQSQGYMTFGKCF
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
LVAKGKAETYNTIDKVNKSSTRLGINIGGTNEIFADTHLQSATFTRYKNNLDVPQAVATG
EEECCCCHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHCCCCCCCHHHHCC
KVDVMVTETPEALYYQATDKRLEASRCDDPFTKSQFGYLVPKGEQELLNAVNFIMDEMKL
CEEEEEECCCCCEEEECHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHH
KGVDKELMKKNALL
CCCCHHHHHHCCCC
>Mature Secondary Structure
MMKKKLLCISVLFAASFTAHADRLDEIQEAGIIRVGTTGDYKPFSSFDGKQFSGYDIDVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
KYIAEQLDVKLELVQTSWKNLIPDLNADKYDIAMGGITRKIQRQLHAEQSQGYMTFGKCF
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
LVAKGKAETYNTIDKVNKSSTRLGINIGGTNEIFADTHLQSATFTRYKNNLDVPQAVATG
EEECCCCHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHCCCCCCCHHHHCC
KVDVMVTETPEALYYQATDKRLEASRCDDPFTKSQFGYLVPKGEQELLNAVNFIMDEMKL
CEEEEEECCCCCEEEECHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHH
KGVDKELMKKNALL
CCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1733946; 10984043; 8515238; 7604006 [H]