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The map label for this gene is patB [H]

Identifier: 59711860

GI number: 59711860

Start: 1393912

End: 1395021

Strand: Reverse

Name: patB [H]

Synonym: VF_1253

Alternate gene names: 59711860

Gene position: 1395021-1393912 (Counterclockwise)

Preceding gene: 59711861

Following gene: 172087695

Centisome position: 48.15

GC content: 41.62

Gene sequence:

>1110_bases
ATGAAAGAAAAACTCGGATTAGATGGCACAGACCGACTACCTATGTGGGTGTCTGATTACGATTTTCAAGCGCCACCACA
CGTATTAGAAGCACTTCATAATCGCATTGACCATGGTATTTTTGGTTATGCAGAACGTAATGATGACTACTACCAAGCGA
TCATCACTTGGTATCAAGAGCAGCATCATATTCACATTGAAAAAGAATGGATAACAACCGTACACGGCGTATTACCTGGG
CTTTCAATGGCAATTCAGCTACTGACTGAAACCAATGACAAAGTGGTAATGCAAACACCGGGCTATGGCTCGTTTCGTAA
AATCGTTGAATTTAATGACCGAGTATTGGTTGAGAACCCATTAATTGAGCAGCAAGGAAACTACACTATCGACCTTGCTC
ATTTAGAATCTTGTTTTCAGCAAGGCGCTAAAGTAATGATCTTCTGTAACCCTCACAACCCTGTTGGTAAAGCATGGTCA
AAAGAAGAGATAACCGCTGTAGCAGAGCTATGTCATCAATACGATGTGTGGCTACTAAGTGATGAGATCTGGGGCGATTT
AGCGATGGGAGATAACACTTACCATTCAGCATTATCATTGCCAGAGAATCTACAACAAAAACTGATTGTAGCAACGGCAG
CGAGTAAAACATTCGGCTTGTCTTCTGTACGTATTTCTAATTTCATGATCCCAAATCAAGAATTAAAAGCACGTTTAGTT
CGTCGTTTAGATGCGCATGGCATGGATGTTTATAATAGCTTGGCGATGTGTGCTGCCACTGCTGCTTATCAAACTTCAGC
ACCGTGGTTAAACGAACTTAAAACCTACTTACAAGAGAACATTACTACCTTAGCAACTTTTATTGAAAGCGAACTGCCAG
AGCTACGCTTTACCCCACCAGAAGCGGGTTATTTAGCATGGGTAGATTGCCGAGATCTTGAACTAACAGATAAAGAACTA
GAGCGTAAATTAGTAGAAGCTGGGATAGTTCCAAGCATGGGGATTGCGTTTGGCAACGAAGGTTCAGGCTTTATTCGTTT
AAATCTAGGTTGCCCTCGAGAGGTACTTATTCAAGCGATGCAGCGAATTAAAGAAGCCTTAGAGAGATAA

Upstream 100 bases:

>100_bases
CTCACTATCTCCAGTTGACGTAAAATAAGGCTATCTCATGACAACTTCTTTTGACTGCATTCACAACCGTTGTAACACAG
GCTCATTAAAATGGGATTTC

Downstream 100 bases:

>100_bases
TCCACACATCCACAAACCATAAAAAAGCCGCTATTAATTAGCGGCTTTTTATCATCATGCCACTATTTGATCTATTTCTT
ACTATACCCAGTAAGTTAAT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNDDYYQAIITWYQEQHHIHIEKEWITTVHGVLPG
LSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVENPLIEQQGNYTIDLAHLESCFQQGAKVMIFCNPHNPVGKAWS
KEEITAVAELCHQYDVWLLSDEIWGDLAMGDNTYHSALSLPENLQQKLIVATAASKTFGLSSVRISNFMIPNQELKARLV
RRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENITTLATFIESELPELRFTPPEAGYLAWVDCRDLELTDKEL
ERKLVEAGIVPSMGIAFGNEGSGFIRLNLGCPREVLIQAMQRIKEALER

Sequences:

>Translated_369_residues
MKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNDDYYQAIITWYQEQHHIHIEKEWITTVHGVLPG
LSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVENPLIEQQGNYTIDLAHLESCFQQGAKVMIFCNPHNPVGKAWS
KEEITAVAELCHQYDVWLLSDEIWGDLAMGDNTYHSALSLPENLQQKLIVATAASKTFGLSSVRISNFMIPNQELKARLV
RRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENITTLATFIESELPELRFTPPEAGYLAWVDCRDLELTDKEL
ERKLVEAGIVPSMGIAFGNEGSGFIRLNLGCPREVLIQAMQRIKEALER
>Mature_369_residues
MKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNDDYYQAIITWYQEQHHIHIEKEWITTVHGVLPG
LSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVENPLIEQQGNYTIDLAHLESCFQQGAKVMIFCNPHNPVGKAWS
KEEITAVAELCHQYDVWLLSDEIWGDLAMGDNTYHSALSLPENLQQKLIVATAASKTFGLSSVRISNFMIPNQELKARLV
RRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENITTLATFIESELPELRFTPPEAGYLAWVDCRDLELTDKEL
ERKLVEAGIVPSMGIAFGNEGSGFIRLNLGCPREVLIQAMQRIKEALER

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=184, Percent_Identity=29.3478260869565, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI56713254, Length=184, Percent_Identity=29.3478260869565, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI187936925, Length=330, Percent_Identity=24.5454545454545, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI14211921, Length=330, Percent_Identity=24.5454545454545, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI95147551, Length=166, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI169881279, Length=166, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=363, Percent_Identity=33.6088154269972, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1788722, Length=369, Percent_Identity=23.5772357723577, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788627, Length=248, Percent_Identity=22.9838709677419, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=362, Percent_Identity=22.3756906077348, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=310, Percent_Identity=23.2258064516129, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=310, Percent_Identity=23.2258064516129, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=278, Percent_Identity=25.1798561151079, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573069, Length=312, Percent_Identity=24.3589743589744, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=312, Percent_Identity=24.3589743589744, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=312, Percent_Identity=24.3589743589744, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=312, Percent_Identity=24.3589743589744, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41841; Mature: 41841

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNDDYYQAIITWYQE
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
QHHIHIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVENP
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEECC
LIEQQGNYTIDLAHLESCFQQGAKVMIFCNPHNPVGKAWSKEEITAVAELCHQYDVWLLS
CCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEC
DEIWGDLAMGDNTYHSALSLPENLQQKLIVATAASKTFGLSSVRISNFMIPNQELKARLV
HHHCCCEECCCCHHHHHHCCCHHHHHHEEEEEECCCCCCCCCEEHHHCCCCCHHHHHHHH
RRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENITTLATFIESELPELRFTPP
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EAGYLAWVDCRDLELTDKELERKLVEAGIVPSMGIAFGNEGSGFIRLNLGCPREVLIQAM
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHH
QRIKEALER
HHHHHHHCC
>Mature Secondary Structure
MKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNDDYYQAIITWYQE
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
QHHIHIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVENP
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEECC
LIEQQGNYTIDLAHLESCFQQGAKVMIFCNPHNPVGKAWSKEEITAVAELCHQYDVWLLS
CCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEC
DEIWGDLAMGDNTYHSALSLPENLQQKLIVATAASKTFGLSSVRISNFMIPNQELKARLV
HHHCCCEECCCCHHHHHHCCCHHHHHHEEEEEECCCCCCCCCEEHHHCCCCCHHHHHHHH
RRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENITTLATFIESELPELRFTPP
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EAGYLAWVDCRDLELTDKELERKLVEAGIVPSMGIAFGNEGSGFIRLNLGCPREVLIQAM
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCHHHHHHHH
QRIKEALER
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]