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The map label for this gene is hutW [H]

Identifier: 59711833

GI number: 59711833

Start: 1359206

End: 1360582

Strand: Direct

Name: hutW [H]

Synonym: VF_1226

Alternate gene names: 59711833

Gene position: 1359206-1360582 (Clockwise)

Preceding gene: 59711826

Following gene: 59711834

Centisome position: 46.91

GC content: 41.76

Gene sequence:

>1377_bases
ATGAGAACAGAAATTGACTTAAATCAGCTACCTATTTCACTTGTCGGTGAAAGTACACCAGAGCCATTGCTGTATGCTTT
TCAAAGAAAAGCATCCGCTCATGCTGGGGGAGGCGCAATACCAATCTCGGCGGATTTGTTTAATGAGCGCTTTTCTTCCG
TTTCATCGGAAACCACACAGCTCAGTAAACATCGTTGCCTTTACGTTCATATCCCTTTTTGTCGTGTGCGATGCACTTAC
TGTAATTTCTTTCAGCACGCTTCAAGCAAGCAACTAGTACAAGAATATTTTGATGCCTTATTAGTTGAGTTGAAATGGAA
AGCACAGCTCGCTTGGACTCAAGCTGCGCCATTTCATGCGGTATATATTGGTGGTGGAACGCCTACGGATCTTACTGCAG
ATCAAATTGAACAATTGGGCAAAGCCATTCGCTCTCAGTTCCCATTAACCCCTGATTGTGAAATTACGCTAGAAGGGCGA
ATTAACCGTTTTGATGAAGAGATGTTTGATAAGTCATTAGAAGGTGGCTTTAATCGTTTTTCATTTGGCGTACAGAGTTT
TAATACAAAAGTAAGACGCTCAGCCAAGAGGCTTGATGATAAAGAGTATGTATTACGTCGTATTCAAGAGTTAAGTGATT
CAGAGCAAGCGCCCATTGTGGTTGATTTACTTTATGGCCTTCCTTATCAAACCTCCGAGATCTGGCAACAAGATCTCAAC
GATTTTTTAGAGACAAACGCACATGGTGTTGATCTTTATCAGCTGATCGAAATGGGCGGAACTCCTATGAAAGGCGTGAT
TGATAAAGGCAAATTGCCACAACCCGCATCAACCGAAGAAAAAGCCTATATGTATAAATATGGTGTGGAGTTCATGAACA
AACATCACCTTAATCGCTTGAGCGTTAATCACTGGGCGCGAAGTAATCGGGAAAGAAGCATCTACAACAGTTTAGCTAAA
ACCACCGCAGAGGTATTGCCAGTGGGGTGTGGTGCTGGTGGTAACCTTGGCGGTGTAGGCATTATGCAACATCGCACGTT
AGACGCCTATATTCAGTCAATTAAAGCTCAACAAATGCCGATTGCAATGATGACACAATCCGCTTCTTCAGCAGGGTTAT
TCTCAATGATTAAAGCAGGGTTTGATCGTGGTGTTCTATCAAGAAAATCACTATTGCAGCAGACGTCAGAGGATGTCTAT
CAATACTTAATGCCACTATTTAAACAGTGGCAAAACAATGGATTAGTTAAGGTTAATGCCGATTATTTAAGTTTAACGTT
AGCGGGTGAATTTTGGGCAGTGACTTTAGCACAAAGTGTGATATCCGCTTTATCAATGACGAACAAACAGCCTGTTTTTA
ATGAACATGCCGCATAA

Upstream 100 bases:

>100_bases
TAATGAGATCAATTATCAATTGCATTCTCATTAAAAAATACTTTATGATGTAAAAAGAAGCAAAACTCTTTGAAGTAACG
AGTTAAAAAGAATTGAAATC

Downstream 100 bases:

>100_bases
ATTTAATCAATATAATAAGAGTATTCCAGTGAATAAACACGTTATCGAATTATTAGAAAATGACCCATCATTATTACCAA
GTGATATAGCTAAGCAACTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MRTEIDLNQLPISLVGESTPEPLLYAFQRKASAHAGGGAIPISADLFNERFSSVSSETTQLSKHRCLYVHIPFCRVRCTY
CNFFQHASSKQLVQEYFDALLVELKWKAQLAWTQAAPFHAVYIGGGTPTDLTADQIEQLGKAIRSQFPLTPDCEITLEGR
INRFDEEMFDKSLEGGFNRFSFGVQSFNTKVRRSAKRLDDKEYVLRRIQELSDSEQAPIVVDLLYGLPYQTSEIWQQDLN
DFLETNAHGVDLYQLIEMGGTPMKGVIDKGKLPQPASTEEKAYMYKYGVEFMNKHHLNRLSVNHWARSNRERSIYNSLAK
TTAEVLPVGCGAGGNLGGVGIMQHRTLDAYIQSIKAQQMPIAMMTQSASSAGLFSMIKAGFDRGVLSRKSLLQQTSEDVY
QYLMPLFKQWQNNGLVKVNADYLSLTLAGEFWAVTLAQSVISALSMTNKQPVFNEHAA

Sequences:

>Translated_458_residues
MRTEIDLNQLPISLVGESTPEPLLYAFQRKASAHAGGGAIPISADLFNERFSSVSSETTQLSKHRCLYVHIPFCRVRCTY
CNFFQHASSKQLVQEYFDALLVELKWKAQLAWTQAAPFHAVYIGGGTPTDLTADQIEQLGKAIRSQFPLTPDCEITLEGR
INRFDEEMFDKSLEGGFNRFSFGVQSFNTKVRRSAKRLDDKEYVLRRIQELSDSEQAPIVVDLLYGLPYQTSEIWQQDLN
DFLETNAHGVDLYQLIEMGGTPMKGVIDKGKLPQPASTEEKAYMYKYGVEFMNKHHLNRLSVNHWARSNRERSIYNSLAK
TTAEVLPVGCGAGGNLGGVGIMQHRTLDAYIQSIKAQQMPIAMMTQSASSAGLFSMIKAGFDRGVLSRKSLLQQTSEDVY
QYLMPLFKQWQNNGLVKVNADYLSLTLAGEFWAVTLAQSVISALSMTNKQPVFNEHAA
>Mature_458_residues
MRTEIDLNQLPISLVGESTPEPLLYAFQRKASAHAGGGAIPISADLFNERFSSVSSETTQLSKHRCLYVHIPFCRVRCTY
CNFFQHASSKQLVQEYFDALLVELKWKAQLAWTQAAPFHAVYIGGGTPTDLTADQIEQLGKAIRSQFPLTPDCEITLEGR
INRFDEEMFDKSLEGGFNRFSFGVQSFNTKVRRSAKRLDDKEYVLRRIQELSDSEQAPIVVDLLYGLPYQTSEIWQQDLN
DFLETNAHGVDLYQLIEMGGTPMKGVIDKGKLPQPASTEEKAYMYKYGVEFMNKHHLNRLSVNHWARSNRERSIYNSLAK
TTAEVLPVGCGAGGNLGGVGIMQHRTLDAYIQSIKAQQMPIAMMTQSASSAGLFSMIKAGFDRGVLSRKSLLQQTSEDVY
QYLMPLFKQWQNNGLVKVNADYLSLTLAGEFWAVTLAQSVISALSMTNKQPVFNEHAA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI87082341, Length=303, Percent_Identity=28.7128712871287, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1789325, Length=190, Percent_Identity=32.1052631578947, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51386; Mature: 51386

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEIDLNQLPISLVGESTPEPLLYAFQRKASAHAGGGAIPISADLFNERFSSVSSETTQ
CCCCCCHHHCCHHEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LSKHRCLYVHIPFCRVRCTYCNFFQHASSKQLVQEYFDALLVELKWKAQLAWTQAAPFHA
HHHCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEE
VYIGGGTPTDLTADQIEQLGKAIRSQFPLTPDCEITLEGRINRFDEEMFDKSLEGGFNRF
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCHHHH
SFGVQSFNTKVRRSAKRLDDKEYVLRRIQELSDSEQAPIVVDLLYGLPYQTSEIWQQDLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCHHHHHHHHHH
DFLETNAHGVDLYQLIEMGGTPMKGVIDKGKLPQPASTEEKAYMYKYGVEFMNKHHLNRL
HHHHCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
SVNHWARSNRERSIYNSLAKTTAEVLPVGCGAGGNLGGVGIMQHRTLDAYIQSIKAQQMP
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
IAMMTQSASSAGLFSMIKAGFDRGVLSRKSLLQQTSEDVYQYLMPLFKQWQNNGLVKVNA
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DYLSLTLAGEFWAVTLAQSVISALSMTNKQPVFNEHAA
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRTEIDLNQLPISLVGESTPEPLLYAFQRKASAHAGGGAIPISADLFNERFSSVSSETTQ
CCCCCCHHHCCHHEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LSKHRCLYVHIPFCRVRCTYCNFFQHASSKQLVQEYFDALLVELKWKAQLAWTQAAPFHA
HHHCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEE
VYIGGGTPTDLTADQIEQLGKAIRSQFPLTPDCEITLEGRINRFDEEMFDKSLEGGFNRF
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCHHHH
SFGVQSFNTKVRRSAKRLDDKEYVLRRIQELSDSEQAPIVVDLLYGLPYQTSEIWQQDLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCHHHHHHHHHH
DFLETNAHGVDLYQLIEMGGTPMKGVIDKGKLPQPASTEEKAYMYKYGVEFMNKHHLNRL
HHHHCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
SVNHWARSNRERSIYNSLAKTTAEVLPVGCGAGGNLGGVGIMQHRTLDAYIQSIKAQQMP
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
IAMMTQSASSAGLFSMIKAGFDRGVLSRKSLLQQTSEDVYQYLMPLFKQWQNNGLVKVNA
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DYLSLTLAGEFWAVTLAQSVISALSMTNKQPVFNEHAA
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]