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The map label for this gene is hmuU [H]

Identifier: 59711828

GI number: 59711828

Start: 1355284

End: 1356321

Strand: Reverse

Name: hmuU [H]

Synonym: VF_1221

Alternate gene names: 59711828

Gene position: 1356321-1355284 (Counterclockwise)

Preceding gene: 59711829

Following gene: 59711827

Centisome position: 46.81

GC content: 40.75

Gene sequence:

>1038_bases
ATGTTGTTAAAATACATCTCTTATTCAAAATTACTGTGGTTAAGTGGCTTTTCTCTGCTAATTATCGCAGTAAGCTCCAT
TGCGACAGGACCAATGAACATTACGCTAAGTGATAGTTTTAATAGCCTTATTCCTTGGTCAACCGCTGAAATTCCGGCAC
ACATTAATTTGATCATTCATCAAGTTCGCCTGCCAAGAACCATCCTTTGTATGCTTGTTGGTGCCATATTGGCTATTTCT
GGTGTTGTCATGCAGGGGTTATTTCGAAATCCTCTTGCTGAACCTGGGATCATTGGTGTATCTGCTGGGGCCGCACTTGG
TGCTGCAATGGCAATCGTAGTATTTTCATCCGTTGCTCAGCAATTTCCTATTTTTATGAATTTTGCTGCTGTTCCTATTT
TTGCTTTTCTTGGTGGCGCAATAACCACACTCATTGTCTATCGATTAGGTACCAGTAAATTTGGTACCTCAATTACTGTT
ATGCTACTCGCTGGTGTTGCTATTAGCGCTTTATCTGGTGCTGGAATTGGCTATTTGAATTTCATTGCCGATGATCAAAT
GCTTCGAGATCTCTCGTTATGGTCTATGGGATCGCTAGCGGGTGCAAAATGGAATGACTTGCTACTTGCAGGTATTGGTC
TTATCACCTTGCTTGTTTTATTTATGAAAAATGCGTCAGGACTTAACGCCCTACTTCTTGGTGAAGCAGAAGCAAAACAT
TTAGGCATTAATGTTCAATCATTAAAGAAACGTATGATCATATTAAGTGCTGTAGGCGTTGGTATTACCGTTAGCTTATC
TGGAATGATTGGGTTTATTGGATTAATCATCCCTCACCTTGGTCGTATGCTATCTGGACCAAACCATAAAACCTTATTAC
CACTTTCAGCATTACTTGGTGGTCTTTTATTAACTGCAGCAGATATGTTTGCCCGTGTTGCCGTTAGCCCTGCTGAACTG
CCTGTTGGTATCGTGACGGCTATTATTGGCGCGCCTTTCTTTTTGTATTTACTCTTTACCCAGCGAGGTAAAATTTAA

Upstream 100 bases:

>100_bases
TATTGGTATTGATGGCTCAGCACTCGTCGGTGGCCTTGGCTTAGCAACACTTGATGAGGCTGCTCGTTTGAATACCCTTC
TTTACCCTTAAGTGATTATT

Downstream 100 bases:

>100_bases
TGAGCCTTTCTTCATTAGCTATCTCAGCCAACAACATTTCTTATCGCATTGGTTCTAAAATAATTTTAGATGACATTAAC
TTAGAACTTCGTTGTGGTGA

Product: hemin transport system permease protein HmuU

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MLLKYISYSKLLWLSGFSLLIIAVSSIATGPMNITLSDSFNSLIPWSTAEIPAHINLIIHQVRLPRTILCMLVGAILAIS
GVVMQGLFRNPLAEPGIIGVSAGAALGAAMAIVVFSSVAQQFPIFMNFAAVPIFAFLGGAITTLIVYRLGTSKFGTSITV
MLLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGAKWNDLLLAGIGLITLLVLFMKNASGLNALLLGEAEAKH
LGINVQSLKKRMIILSAVGVGITVSLSGMIGFIGLIIPHLGRMLSGPNHKTLLPLSALLGGLLLTAADMFARVAVSPAEL
PVGIVTAIIGAPFFLYLLFTQRGKI

Sequences:

>Translated_345_residues
MLLKYISYSKLLWLSGFSLLIIAVSSIATGPMNITLSDSFNSLIPWSTAEIPAHINLIIHQVRLPRTILCMLVGAILAIS
GVVMQGLFRNPLAEPGIIGVSAGAALGAAMAIVVFSSVAQQFPIFMNFAAVPIFAFLGGAITTLIVYRLGTSKFGTSITV
MLLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGAKWNDLLLAGIGLITLLVLFMKNASGLNALLLGEAEAKH
LGINVQSLKKRMIILSAVGVGITVSLSGMIGFIGLIIPHLGRMLSGPNHKTLLPLSALLGGLLLTAADMFARVAVSPAEL
PVGIVTAIIGAPFFLYLLFTQRGKI
>Mature_345_residues
MLLKYISYSKLLWLSGFSLLIIAVSSIATGPMNITLSDSFNSLIPWSTAEIPAHINLIIHQVRLPRTILCMLVGAILAIS
GVVMQGLFRNPLAEPGIIGVSAGAALGAAMAIVVFSSVAQQFPIFMNFAAVPIFAFLGGAITTLIVYRLGTSKFGTSITV
MLLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGAKWNDLLLAGIGLITLLVLFMKNASGLNALLLGEAEAKH
LGINVQSLKKRMIILSAVGVGITVSLSGMIGFIGLIIPHLGRMLSGPNHKTLLPLSALLGGLLLTAADMFARVAVSPAEL
PVGIVTAIIGAPFFLYLLFTQRGKI

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=285, Percent_Identity=40.7017543859649, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=37.5438596491228, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790741, Length=334, Percent_Identity=31.437125748503, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786805, Length=298, Percent_Identity=37.5838926174497, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=31.1827956989247, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1786804, Length=316, Percent_Identity=27.5316455696203, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36154; Mature: 36154

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKYISYSKLLWLSGFSLLIIAVSSIATGPMNITLSDSFNSLIPWSTAEIPAHINLIIH
CEEEHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
QVRLPRTILCMLVGAILAISGVVMQGLFRNPLAEPGIIGVSAGAALGAAMAIVVFSSVAQ
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
QFPIFMNFAAVPIFAFLGGAITTLIVYRLGTSKFGTSITVMLLAGVAISALSGAGIGYLN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
FIADDQMLRDLSLWSMGSLAGAKWNDLLLAGIGLITLLVLFMKNASGLNALLLGEAEAKH
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHH
LGINVQSLKKRMIILSAVGVGITVSLSGMIGFIGLIIPHLGRMLSGPNHKTLLPLSALLG
HCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
GLLLTAADMFARVAVSPAELPVGIVTAIIGAPFFLYLLFTQRGKI
HHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLKYISYSKLLWLSGFSLLIIAVSSIATGPMNITLSDSFNSLIPWSTAEIPAHINLIIH
CEEEHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
QVRLPRTILCMLVGAILAISGVVMQGLFRNPLAEPGIIGVSAGAALGAAMAIVVFSSVAQ
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
QFPIFMNFAAVPIFAFLGGAITTLIVYRLGTSKFGTSITVMLLAGVAISALSGAGIGYLN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
FIADDQMLRDLSLWSMGSLAGAKWNDLLLAGIGLITLLVLFMKNASGLNALLLGEAEAKH
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHH
LGINVQSLKKRMIILSAVGVGITVSLSGMIGFIGLIIPHLGRMLSGPNHKTLLPLSALLG
HCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
GLLLTAADMFARVAVSPAELPVGIVTAIIGAPFFLYLLFTQRGKI
HHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]