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The map label for this gene is sdaC [H]

Identifier: 59711784

GI number: 59711784

Start: 1306563

End: 1307822

Strand: Reverse

Name: sdaC [H]

Synonym: VF_1177

Alternate gene names: 59711784

Gene position: 1307822-1306563 (Counterclockwise)

Preceding gene: 59711785

Following gene: 59711783

Centisome position: 45.14

GC content: 41.75

Gene sequence:

>1260_bases
ATGTTAATTATGCAAACAACAAATACTGCATCTATCGGTGCAAAAAAAACTAAGTGGACTTATAAAGATTTCACTTGGTG
TCTTTCTCTGTTCGGTACCGCTGTAGGTGCTGGTGTTCTTTTCCTTCCAATCAAAGCGGGTGCTGGTGGTTTTTGGCCTC
TAGTTATTCTTGCTCTAATCGCTGCACCAATGACTTGGTTTGCTCACAAGAGTTTGGCTCGTTTCGTTCTTTCAGCTAAA
AACCCAGATGCAGATATTACTGATACTGTAGAAGAGCATTTCGGTAAAACAGGCGCGAACCTAATCACTTTTGCCTACTT
TTTCGCGATTTATCCGATTGTACTTATCTACGGTGTTGGTATTACAAACACAGTAGACTCTTTCATGGTTAACCAAATGG
GTATGGAATCTATCCCTCGTTGGTTACTATCAGGTGTTCTTATCACTCTGATGACATGTGGTGTAGTATTTGGTAAAGAA
CTAATGCTGAAAGCAACTTCAGCAATGGTTTACCCTCTTGTATTCATCTTAATGGCTCTTTCTGTATACCTAATCCCTGG
TTGGAACACATCTATGATGTCTGTTGACCCAGATTGGGGTTCAATGCCTTCTGTTGTTTGGTTAGCGATTCCTATCATCG
TTTTCTCTTTCAACCACAGCCCAGTAATCAGCCAGTTCTCTAAAGAACAACGTCGTGTATACGGTGAAGATGCAGTTGCT
AAAACTGACATGATCACTGGCGGTGCAGCAATGATGCTAATGAGCTTCGTTATGTTCTTCGTTTTCTCTGTAGTTCTTTC
TCTATCTCCAGAGCAACTAGCGCAAGCACAAGCACAGAACATCTCTGTACTTTCTTACCTAGCAAACGTACACGAATCTC
CACTTATCTCTTACTTAGGTCCAATCGTTGCTTTCGCTGCGATTACTTCAAGCTACTTCGGTCACTTCCTAGGTGCTCAC
GAAGGTCTCGTTGGCCTAGCTAAATCTCGCTCAAAAGCACCAGTTGCTAAGCTAGAAAAAGCATCTCTAATCTTTATCGT
TGTTACTACATGGATCGTTTCTATCATCAACCCAAGTATCCTAGGTATGATTGAAACAATGGGTGCTCCAATGATTGCAG
CTATCCTATTCCTTATGCCTATCTTCGCAATGCGTAAAGTTCCAGCAATGGCTAAGTACAAAACTTCAGCACCTGTGCAA
ATCTTTACAGCATTATGTGGTGTTGCGGCGATTACTTCTGTAATCTACGGCGCTCTTTAA

Upstream 100 bases:

>100_bases
GTTCATCTTTTTTCATTTCTGGATCTGGGTCAAAGTTTTTCTCGTCAAAATAACGACAATAGCGCCGTTCCTAAAATTCC
TGTTCCAAAAAATTAAGAGT

Downstream 100 bases:

>100_bases
TAACTAATTTGTAAACTAATACAAACTTAGTTAAACGAAGTTAATAATAATGATAATAAAGCCCCCTCTTTTGGGGGCTT
ATTCGAGGTAATTACATGAT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLIMQTTNTASIGAKKTKWTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVILALIAAPMTWFAHKSLARFVLSAK
NPDADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFMVNQMGMESIPRWLLSGVLITLMTCGVVFGKE
LMLKATSAMVYPLVFILMALSVYLIPGWNTSMMSVDPDWGSMPSVVWLAIPIIVFSFNHSPVISQFSKEQRRVYGEDAVA
KTDMITGGAAMMLMSFVMFFVFSVVLSLSPEQLAQAQAQNISVLSYLANVHESPLISYLGPIVAFAAITSSYFGHFLGAH
EGLVGLAKSRSKAPVAKLEKASLIFIVVTTWIVSIINPSILGMIETMGAPMIAAILFLMPIFAMRKVPAMAKYKTSAPVQ
IFTALCGVAAITSVIYGAL

Sequences:

>Translated_419_residues
MLIMQTTNTASIGAKKTKWTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVILALIAAPMTWFAHKSLARFVLSAK
NPDADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFMVNQMGMESIPRWLLSGVLITLMTCGVVFGKE
LMLKATSAMVYPLVFILMALSVYLIPGWNTSMMSVDPDWGSMPSVVWLAIPIIVFSFNHSPVISQFSKEQRRVYGEDAVA
KTDMITGGAAMMLMSFVMFFVFSVVLSLSPEQLAQAQAQNISVLSYLANVHESPLISYLGPIVAFAAITSSYFGHFLGAH
EGLVGLAKSRSKAPVAKLEKASLIFIVVTTWIVSIINPSILGMIETMGAPMIAAILFLMPIFAMRKVPAMAKYKTSAPVQ
IFTALCGVAAITSVIYGAL
>Mature_419_residues
MLIMQTTNTASIGAKKTKWTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVILALIAAPMTWFAHKSLARFVLSAK
NPDADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVGITNTVDSFMVNQMGMESIPRWLLSGVLITLMTCGVVFGKE
LMLKATSAMVYPLVFILMALSVYLIPGWNTSMMSVDPDWGSMPSVVWLAIPIIVFSFNHSPVISQFSKEQRRVYGEDAVA
KTDMITGGAAMMLMSFVMFFVFSVVLSLSPEQLAQAQAQNISVLSYLANVHESPLISYLGPIVAFAAITSSYFGHFLGAH
EGLVGLAKSRSKAPVAKLEKASLIFIVVTTWIVSIINPSILGMIETMGAPMIAAILFLMPIFAMRKVPAMAKYKTSAPVQ
IFTALCGVAAITSVIYGAL

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=426, Percent_Identity=50.9389671361502, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=42.7601809954751, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1789211, Length=385, Percent_Identity=33.7662337662338, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789961, Length=404, Percent_Identity=26.7326732673267, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI145693183, Length=399, Percent_Identity=23.5588972431078, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 45349; Mature: 45349

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIMQTTNTASIGAKKTKWTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVILALI
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
AAPMTWFAHKSLARFVLSAKNPDADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
ITNTVDSFMVNQMGMESIPRWLLSGVLITLMTCGVVFGKELMLKATSAMVYPLVFILMAL
CHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVYLIPGWNTSMMSVDPDWGSMPSVVWLAIPIIVFSFNHSPVISQFSKEQRRVYGEDAVA
HHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
KTDMITGGAAMMLMSFVMFFVFSVVLSLSPEQLAQAQAQNISVLSYLANVHESPLISYLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
PIVAFAAITSSYFGHFLGAHEGLVGLAKSRSKAPVAKLEKASLIFIVVTTWIVSIINPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCHHH
LGMIETMGAPMIAAILFLMPIFAMRKVPAMAKYKTSAPVQIFTALCGVAAITSVIYGAL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIMQTTNTASIGAKKTKWTYKDFTWCLSLFGTAVGAGVLFLPIKAGAGGFWPLVILALI
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
AAPMTWFAHKSLARFVLSAKNPDADITDTVEEHFGKTGANLITFAYFFAIYPIVLIYGVG
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
ITNTVDSFMVNQMGMESIPRWLLSGVLITLMTCGVVFGKELMLKATSAMVYPLVFILMAL
CHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVYLIPGWNTSMMSVDPDWGSMPSVVWLAIPIIVFSFNHSPVISQFSKEQRRVYGEDAVA
HHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
KTDMITGGAAMMLMSFVMFFVFSVVLSLSPEQLAQAQAQNISVLSYLANVHESPLISYLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
PIVAFAAITSSYFGHFLGAHEGLVGLAKSRSKAPVAKLEKASLIFIVVTTWIVSIINPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCHHH
LGMIETMGAPMIAAILFLMPIFAMRKVPAMAKYKTSAPVQIFTALCGVAAITSVIYGAL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]