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The map label for this gene is tcpI [H]

Identifier: 59711724

GI number: 59711724

Start: 1231418

End: 1233232

Strand: Direct

Name: tcpI [H]

Synonym: VF_1117

Alternate gene names: 59711724

Gene position: 1231418-1233232 (Clockwise)

Preceding gene: 59711723

Following gene: 59711725

Centisome position: 42.5

GC content: 30.63

Gene sequence:

>1815_bases
ATGAATGGATATAGAGCATTTTATAATTTCAATGAAAAAGTAGCGATTGAGTCTATTAATGACCGTTCTAAATTGTTAGC
ATCTTCACTTGAGGAAAAAATAAATGGGTATTTTTCATCTTTAAATTCATTTTCTATTTATTTTAAAGATGATGGTAGTT
TTGATGAAGAAGCTACTGCAAAAAGCTTAAAATTACTGGCTGAAGCTAATGATGTACAAAATGCATTTATTGGGTTTAAA
GATGGAAAAGTATTTAGTATCGATGGAAATTTATCTAATTTAAATGCAAAAGAATCAAGAAGAGAGTGGTATACAAAGAT
CTTCTCTGGTGAAGATAGAGTAATAACCAAAGTATATAAAGATGCTAATAACCTAAATGTATTTGCGTTTGCCGTTCCTA
TTTTAAATAATAATAAAGAAATAATTGCTACTGTTGCATTTGGTATTAAACAAGATACTTTGAATGAAGCAATGTTAAAG
CTGTCAAATAAGAACCAGATTTATACATTCATACACGATGGATATATTATCACTGCACAGAATAAAGAAAATATTGGTAA
AAATATCAATGTTCTTGCTAAAGGCTTAGATGATTATAATGGAGATTATGTTAGGCTTTTTGATAAGAATAAAAATGATT
ATTTTATTGCATCTAATACTAAAATTGAAAAATATAATTTAACAATATCTGTATATGAGTATGAAGATGATATTTATAAT
GCCAGCAAAAATATGTTTTTTGATTCTATACTAATTCTTTCTGCATTATTAATGATTATGTTGCCTATTATCTATTATGG
AGTTATTTATTTAATCTACAAACCTATTGGAGGTGAACCAGTCAGAATATCTGAAATTTTATCTAATATTGCTAATGGTG
ATTTATCTCAACCATTAAGGTCTTCTGATAAAGATACTGGAATTTATCGCTCAGTTACTCTATTAGCTCGTAAGATGTCT
GAAATTGTGACAAATAGCCATTCGATTTCCAATAATGTTTCAGCGGCAACAGAAGAAGTTTCTGTTGTTATGTTAGATAC
CGCTCAAAATGCTCAAAATGAACTTGCTCAAGTAGAAGAGATTTCAACAGCAATTAGTGAACTGTCCAGTACATCAAAAG
AAGTCACTAAAAATGCAACTTATGCTGAAAATGAAGTTGCAAAGGCTAAAAACAGTGTATTAAATGGACGTAAAGCAATT
AAAGATAAGCTTGATAAAACTAATGGTATTCATGATTCAATACAAGTTACGGTACAACTTATTTCAGAGTTAAAGACTGA
TACACTTAATATTAGTGAAGTTACTGATGTAATAGATTCTATATCAGAACAGACTAATTTACTTGCATTGAATGCAGCAA
TTGAAGCGGCAAGAGCGGGTGATGCTGGTCGAGGTTTTGCTGTTGTAGCAGATGAAGTTAGGACTCTAGCCGCAAAAACA
CAAGACTCAACACTTCATATTCAAAATATTATTACTAAACTGCAGTCGCAAGCAGAAAAAGTAAACGACAATATTATGCT
GAATGTCGATGTCATTAAAGAATCGATGGGTTTGGCTAAAAATGTCCAAACTGCTTTTACACAGATTTCAGATTCAGTTG
ATAATATATCGGATATCAGTACGTTAGTTGCTACAGCATCGCAAGAACAACTTCACGTAACAGAAGAGATTGCTCAAAAC
ACAATACGAACGTTTGATCTAGTTACTCAAAATGTATCAGCAATTAATCAAACACAACAAGCTACCAAAGAAGTATCGAA
GTTAGCTGTTGCGCAAAAAACAGAATTAGATTTCTTTAAAGTTGCTTCATCATAA

Upstream 100 bases:

>100_bases
TGAAATCATTTAAATAATATGGAGAGTAAAGGTGCTTTTAAAAAATAAGATTCTAGTATATTCATCGATATTGGTGGTGG
TTGTTGCAACTTTATTAACA

Downstream 100 bases:

>100_bases
TAATCATAGTGCAGCTGTTATCAATATCAAAGGCCTCACAGGTAGCACTGTGAGGCCTTTTTTTATGAAAAATCAGACAC
CTCTGGTATAGCAACAAGAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpI [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNGYRAFYNFNEKVAIESINDRSKLLASSLEEKINGYFSSLNSFSIYFKDDGSFDEEATAKSLKLLAEANDVQNAFIGFK
DGKVFSIDGNLSNLNAKESRREWYTKIFSGEDRVITKVYKDANNLNVFAFAVPILNNNKEIIATVAFGIKQDTLNEAMLK
LSNKNQIYTFIHDGYIITAQNKENIGKNINVLAKGLDDYNGDYVRLFDKNKNDYFIASNTKIEKYNLTISVYEYEDDIYN
ASKNMFFDSILILSALLMIMLPIIYYGVIYLIYKPIGGEPVRISEILSNIANGDLSQPLRSSDKDTGIYRSVTLLARKMS
EIVTNSHSISNNVSAATEEVSVVMLDTAQNAQNELAQVEEISTAISELSSTSKEVTKNATYAENEVAKAKNSVLNGRKAI
KDKLDKTNGIHDSIQVTVQLISELKTDTLNISEVTDVIDSISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAAKT
QDSTLHIQNIITKLQSQAEKVNDNIMLNVDVIKESMGLAKNVQTAFTQISDSVDNISDISTLVATASQEQLHVTEEIAQN
TIRTFDLVTQNVSAINQTQQATKEVSKLAVAQKTELDFFKVASS

Sequences:

>Translated_604_residues
MNGYRAFYNFNEKVAIESINDRSKLLASSLEEKINGYFSSLNSFSIYFKDDGSFDEEATAKSLKLLAEANDVQNAFIGFK
DGKVFSIDGNLSNLNAKESRREWYTKIFSGEDRVITKVYKDANNLNVFAFAVPILNNNKEIIATVAFGIKQDTLNEAMLK
LSNKNQIYTFIHDGYIITAQNKENIGKNINVLAKGLDDYNGDYVRLFDKNKNDYFIASNTKIEKYNLTISVYEYEDDIYN
ASKNMFFDSILILSALLMIMLPIIYYGVIYLIYKPIGGEPVRISEILSNIANGDLSQPLRSSDKDTGIYRSVTLLARKMS
EIVTNSHSISNNVSAATEEVSVVMLDTAQNAQNELAQVEEISTAISELSSTSKEVTKNATYAENEVAKAKNSVLNGRKAI
KDKLDKTNGIHDSIQVTVQLISELKTDTLNISEVTDVIDSISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAAKT
QDSTLHIQNIITKLQSQAEKVNDNIMLNVDVIKESMGLAKNVQTAFTQISDSVDNISDISTLVATASQEQLHVTEEIAQN
TIRTFDLVTQNVSAINQTQQATKEVSKLAVAQKTELDFFKVASS
>Mature_604_residues
MNGYRAFYNFNEKVAIESINDRSKLLASSLEEKINGYFSSLNSFSIYFKDDGSFDEEATAKSLKLLAEANDVQNAFIGFK
DGKVFSIDGNLSNLNAKESRREWYTKIFSGEDRVITKVYKDANNLNVFAFAVPILNNNKEIIATVAFGIKQDTLNEAMLK
LSNKNQIYTFIHDGYIITAQNKENIGKNINVLAKGLDDYNGDYVRLFDKNKNDYFIASNTKIEKYNLTISVYEYEDDIYN
ASKNMFFDSILILSALLMIMLPIIYYGVIYLIYKPIGGEPVRISEILSNIANGDLSQPLRSSDKDTGIYRSVTLLARKMS
EIVTNSHSISNNVSAATEEVSVVMLDTAQNAQNELAQVEEISTAISELSSTSKEVTKNATYAENEVAKAKNSVLNGRKAI
KDKLDKTNGIHDSIQVTVQLISELKTDTLNISEVTDVIDSISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAAKT
QDSTLHIQNIITKLQSQAEKVNDNIMLNVDVIKESMGLAKNVQTAFTQISDSVDNISDISTLVATASQEQLHVTEEIAQN
TIRTFDLVTQNVSAINQTQQATKEVSKLAVAQKTELDFFKVASS

Specific function: May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (tcpA) [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=310, Percent_Identity=29.3548387096774, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI2367378, Length=330, Percent_Identity=26.0606060606061, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1787690, Length=369, Percent_Identity=27.10027100271, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788194, Length=344, Percent_Identity=27.3255813953488, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789453, Length=323, Percent_Identity=26.0061919504644, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004089 [H]

Pfam domain/function: PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 66837; Mature: 66837

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYRAFYNFNEKVAIESINDRSKLLASSLEEKINGYFSSLNSFSIYFKDDGSFDEEATA
CCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
KSLKLLAEANDVQNAFIGFKDGKVFSIDGNLSNLNAKESRREWYTKIFSGEDRVITKVYK
HHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
DANNLNVFAFAVPILNNNKEIIATVAFGIKQDTLNEAMLKLSNKNQIYTFIHDGYIITAQ
CCCCCEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCEEEEEC
NKENIGKNINVLAKGLDDYNGDYVRLFDKNKNDYFIASNTKIEKYNLTISVYEYEDDIYN
CHHCCCCCHHHHEECCCCCCCCEEEEEECCCCCEEEEECCEEEEEEEEEEEEEECCHHHC
ASKNMFFDSILILSALLMIMLPIIYYGVIYLIYKPIGGEPVRISEILSNIANGDLSQPLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHHHHHHCCCCCCCHHH
SSDKDTGIYRSVTLLARKMSEIVTNSHSISNNVSAATEEVSVVMLDTAQNAQNELAQVEE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHHHH
ISTAISELSSTSKEVTKNATYAENEVAKAKNSVLNGRKAIKDKLDKTNGIHDSIQVTVQL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ISELKTDTLNISEVTDVIDSISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAAKT
HHHHCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCEEEEHHHHHHHHHCC
QDSTLHIQNIITKLQSQAEKVNDNIMLNVDVIKESMGLAKNVQTAFTQISDSVDNISDIS
CCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVATASQEQLHVTEEIAQNTIRTFDLVTQNVSAINQTQQATKEVSKLAVAQKTELDFFK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VASS
ECCC
>Mature Secondary Structure
MNGYRAFYNFNEKVAIESINDRSKLLASSLEEKINGYFSSLNSFSIYFKDDGSFDEEATA
CCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
KSLKLLAEANDVQNAFIGFKDGKVFSIDGNLSNLNAKESRREWYTKIFSGEDRVITKVYK
HHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
DANNLNVFAFAVPILNNNKEIIATVAFGIKQDTLNEAMLKLSNKNQIYTFIHDGYIITAQ
CCCCCEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCEEEEEC
NKENIGKNINVLAKGLDDYNGDYVRLFDKNKNDYFIASNTKIEKYNLTISVYEYEDDIYN
CHHCCCCCHHHHEECCCCCCCCEEEEEECCCCCEEEEECCEEEEEEEEEEEEEECCHHHC
ASKNMFFDSILILSALLMIMLPIIYYGVIYLIYKPIGGEPVRISEILSNIANGDLSQPLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEHHHHHHHHCCCCCCCHHH
SSDKDTGIYRSVTLLARKMSEIVTNSHSISNNVSAATEEVSVVMLDTAQNAQNELAQVEE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCHHHHHHHHHH
ISTAISELSSTSKEVTKNATYAENEVAKAKNSVLNGRKAIKDKLDKTNGIHDSIQVTVQL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ISELKTDTLNISEVTDVIDSISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRTLAAKT
HHHHCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCEEEEHHHHHHHHHCC
QDSTLHIQNIITKLQSQAEKVNDNIMLNVDVIKESMGLAKNVQTAFTQISDSVDNISDIS
CCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLVATASQEQLHVTEEIAQNTIRTFDLVTQNVSAINQTQQATKEVSKLAVAQKTELDFFK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VASS
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8005659 [H]