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The map label for this gene is 59711583

Identifier: 59711583

GI number: 59711583

Start: 1071496

End: 1072956

Strand: Direct

Name: 59711583

Synonym: VF_0976

Alternate gene names: NA

Gene position: 1071496-1072956 (Clockwise)

Preceding gene: 59711582

Following gene: 172087681

Centisome position: 36.98

GC content: 39.15

Gene sequence:

>1461_bases
ATGAATACAGAAAAAAAACTGTTGGTTTCTCAACAAATCATTGAAGATGCATGTGAATGGGCAATCATGCATGGGGTAGC
ATTCAGACAAGCAGATAATACGGCAAGACATTGTCCATTTAGTATCGCTCCTATGAGTATCGAGCGTGATGTGTATCAAC
ATTTGTTGAGAGTGACTCCGTTAATCACTAAATTAATCCATAACGTTTCTGAAGATCATGATTTTCTCCAATCATCATTA
AGTGATATGGCAAAAGCTGATCCGTTCTTTGGTTTATTAATGTCATTACATCAACAACTGCATGGTGACGCTCATAATAA
ACTTGTTGCTGAGCGTCAGCCGTTATTATTGATGCGAACTGATTTTATGGATGATCGTCAACACGGTGCAAAAGTCATTG
AATTTAATGGTATTGCAGCTGGCATGGGGCCTTTTGGTCAACGAGCGGCAGAACTTCATGCGTTTATGAAACAGCAATGG
CCAAATACGTATCACCAATGGATTGAAGATGCATCGGCTGTGCCTGCTGAAAATCAAGGTTTAGAACAACTTGCATATGG
TATTGCAGCGGCAGCGAAATCGGTAAATGCGCATTTTGGTAATGAAAGCAAACCGACATTCTTGATGGTTGTACAAAAGA
ATGAAGATAACGTGTATGACCAACATTTGTTGGAAGTTGAACTCCAAAAGCAAGGTGTTCGAACGGTTCGAAGAACGTTT
GAACAATTAAGAACTCAGCTATCTAGTGGTGATAATAAACGTTTATTGCTAGAAAACGTTGGTGCTGTTGATGTGGTTTA
TTTACGTGCAGGCTATCAGTATGAGGATTATTTCTCAGCAGAGCTTAATGAGCCTATTTGTTGTCATACGTTGAGCCAAA
CAAGGTTATTTATTGAACAGCATCATGTTGCCGTTAATGCAACGATTAGTCAGCAATTAGCGACCAGTAAATCAATGCAA
ATGTTGTTAACTATGATGCCAGAAAGTGAATATTCTCGTTGGGGATTGAGTATAGATGAAGCATCATTGGTTAAAAGCGT
TTTAGCTGATATGAAACCGATTAATACCGATACTATTCATTGGTTTACCCTTAATGCAAATAAGTCTGAATGGGTATTAA
AAAATCAAGGTGAAGGTGGTGGTCATTGCGTTTTTGGTGATGATATTACCCAAAAGCTTAATCAATTAGATGCTGCAGAA
TATGATGCATGGGCGTTAATGCAGCGCTTATACCCTCATGAACGTGATACACCAACGGTTGCGGTTCGAGATGGTGAACA
GACTCTTGTAAATGATTTAGTGAGCGAAATAGGGCTGTTTACCGCTTATTACAATGGTAAGCCGGTCACTGAGCTGAATG
GTTATGCGGGTTATTTAATTCGTAGTAAGCCTGCCAGTGAAAATGAAGGTGGAATTCATAGCGGAAAAGGCATTTTAGAT
TCTCTGGTTTTAGTGGATTAA

Upstream 100 bases:

>100_bases
TTTAGCGCAAAAAGCGCAAGAAGAAAATGAACATCAGAATAGCACACTTGGTTTAGCTGGAATTAACGCAGCTTGAATTA
TTGAATTTAGAGTTATAAAA

Downstream 100 bases:

>100_bases
CTTTTCCTTAATACAAACTGAACCAAACATTAAAATAGCTCACAAAAAATACGAGTCTCAATTGTGGACTCACACTCAGT
TTATGCATTTAAGTACCTTA

Product: glutathione synthetase

Products: ADP; phosphate; glutathione

Alternate protein names: Glutathione Synthetase

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNTEKKLLVSQQIIEDACEWAIMHGVAFRQADNTARHCPFSIAPMSIERDVYQHLLRVTPLITKLIHNVSEDHDFLQSSL
SDMAKADPFFGLLMSLHQQLHGDAHNKLVAERQPLLLMRTDFMDDRQHGAKVIEFNGIAAGMGPFGQRAAELHAFMKQQW
PNTYHQWIEDASAVPAENQGLEQLAYGIAAAAKSVNAHFGNESKPTFLMVVQKNEDNVYDQHLLEVELQKQGVRTVRRTF
EQLRTQLSSGDNKRLLLENVGAVDVVYLRAGYQYEDYFSAELNEPICCHTLSQTRLFIEQHHVAVNATISQQLATSKSMQ
MLLTMMPESEYSRWGLSIDEASLVKSVLADMKPINTDTIHWFTLNANKSEWVLKNQGEGGGHCVFGDDITQKLNQLDAAE
YDAWALMQRLYPHERDTPTVAVRDGEQTLVNDLVSEIGLFTAYYNGKPVTELNGYAGYLIRSKPASENEGGIHSGKGILD
SLVLVD

Sequences:

>Translated_486_residues
MNTEKKLLVSQQIIEDACEWAIMHGVAFRQADNTARHCPFSIAPMSIERDVYQHLLRVTPLITKLIHNVSEDHDFLQSSL
SDMAKADPFFGLLMSLHQQLHGDAHNKLVAERQPLLLMRTDFMDDRQHGAKVIEFNGIAAGMGPFGQRAAELHAFMKQQW
PNTYHQWIEDASAVPAENQGLEQLAYGIAAAAKSVNAHFGNESKPTFLMVVQKNEDNVYDQHLLEVELQKQGVRTVRRTF
EQLRTQLSSGDNKRLLLENVGAVDVVYLRAGYQYEDYFSAELNEPICCHTLSQTRLFIEQHHVAVNATISQQLATSKSMQ
MLLTMMPESEYSRWGLSIDEASLVKSVLADMKPINTDTIHWFTLNANKSEWVLKNQGEGGGHCVFGDDITQKLNQLDAAE
YDAWALMQRLYPHERDTPTVAVRDGEQTLVNDLVSEIGLFTAYYNGKPVTELNGYAGYLIRSKPASENEGGIHSGKGILD
SLVLVD
>Mature_486_residues
MNTEKKLLVSQQIIEDACEWAIMHGVAFRQADNTARHCPFSIAPMSIERDVYQHLLRVTPLITKLIHNVSEDHDFLQSSL
SDMAKADPFFGLLMSLHQQLHGDAHNKLVAERQPLLLMRTDFMDDRQHGAKVIEFNGIAAGMGPFGQRAAELHAFMKQQW
PNTYHQWIEDASAVPAENQGLEQLAYGIAAAAKSVNAHFGNESKPTFLMVVQKNEDNVYDQHLLEVELQKQGVRTVRRTF
EQLRTQLSSGDNKRLLLENVGAVDVVYLRAGYQYEDYFSAELNEPICCHTLSQTRLFIEQHHVAVNATISQQLATSKSMQ
MLLTMMPESEYSRWGLSIDEASLVKSVLADMKPINTDTIHWFTLNANKSEWVLKNQGEGGGHCVFGDDITQKLNQLDAAE
YDAWALMQRLYPHERDTPTVAVRDGEQTLVNDLVSEIGLFTAYYNGKPVTELNGYAGYLIRSKPASENEGGIHSGKGILD
SLVLVD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4504169, Length=497, Percent_Identity=26.1569416498994, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17535239, Length=492, Percent_Identity=25.8130081300813, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324524, Length=500, Percent_Identity=26.6, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281361051, Length=500, Percent_Identity=25.6, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24642900, Length=500, Percent_Identity=25.6, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281361044, Length=500, Percent_Identity=25.6, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281361034, Length=500, Percent_Identity=25.6, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281361053, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281376915, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281361042, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281361040, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.2.3

Molecular weight: Translated: 54630; Mature: 54630

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEKKLLVSQQIIEDACEWAIMHGVAFRQADNTARHCPFSIAPMSIERDVYQHLLRVTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEECCCHHHHHHHHHHHHHHH
LITKLIHNVSEDHDFLQSSLSDMAKADPFFGLLMSLHQQLHGDAHNKLVAERQPLLLMRT
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC
DFMDDRQHGAKVIEFNGIAAGMGPFGQRAAELHAFMKQQWPNTYHQWIEDASAVPAENQG
CCCCCHHCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
LEQLAYGIAAAAKSVNAHFGNESKPTFLMVVQKNEDNVYDQHLLEVELQKQGVRTVRRTF
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQLRTQLSSGDNKRLLLENVGAVDVVYLRAGYQYEDYFSAELNEPICCHTLSQTRLFIEQ
HHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCEEECHHHHHHHHHH
HHVAVNATISQQLATSKSMQMLLTMMPESEYSRWGLSIDEASLVKSVLADMKPINTDTIH
HCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEE
WFTLNANKSEWVLKNQGEGGGHCVFGDDITQKLNQLDAAEYDAWALMQRLYPHERDTPTV
EEEEECCCCCEEEECCCCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
AVRDGEQTLVNDLVSEIGLFTAYYNGKPVTELNGYAGYLIRSKPASENEGGIHSGKGILD
EEECCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
SLVLVD
HHHHCC
>Mature Secondary Structure
MNTEKKLLVSQQIIEDACEWAIMHGVAFRQADNTARHCPFSIAPMSIERDVYQHLLRVTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEECCCHHHHHHHHHHHHHHH
LITKLIHNVSEDHDFLQSSLSDMAKADPFFGLLMSLHQQLHGDAHNKLVAERQPLLLMRT
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC
DFMDDRQHGAKVIEFNGIAAGMGPFGQRAAELHAFMKQQWPNTYHQWIEDASAVPAENQG
CCCCCHHCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
LEQLAYGIAAAAKSVNAHFGNESKPTFLMVVQKNEDNVYDQHLLEVELQKQGVRTVRRTF
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQLRTQLSSGDNKRLLLENVGAVDVVYLRAGYQYEDYFSAELNEPICCHTLSQTRLFIEQ
HHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCEEECHHHHHHHHHH
HHVAVNATISQQLATSKSMQMLLTMMPESEYSRWGLSIDEASLVKSVLADMKPINTDTIH
HCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEE
WFTLNANKSEWVLKNQGEGGGHCVFGDDITQKLNQLDAAEYDAWALMQRLYPHERDTPTV
EEEEECCCCCEEEECCCCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
AVRDGEQTLVNDLVSEIGLFTAYYNGKPVTELNGYAGYLIRSKPASENEGGIHSGKGILD
EEECCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
SLVLVD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; gamma-L-glutamyl-L-cysteine; glycine

Specific reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA