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The map label for this gene is moaA [H]

Identifier: 59711547

GI number: 59711547

Start: 1036536

End: 1037525

Strand: Direct

Name: moaA [H]

Synonym: VF_0940

Alternate gene names: 59711547

Gene position: 1036536-1037525 (Clockwise)

Preceding gene: 59711545

Following gene: 59711548

Centisome position: 35.77

GC content: 38.18

Gene sequence:

>990_bases
GTGGCGCAACAATTCGCAGATAATTTTGATCGTAAGTTCTATTACTTACGATTATCAGTTACAGATGTCTGTAACTTTAA
ATGTACTTATTGCTTACCTGATGGTTATAAACCAGAAAATGGAAAGCGTGAGTCCTTCCTTGAACTTGATGAAATCGAAC
GTACTGTTAGTGCGTTTGCTCGTTGTGGTACGTCTAAAGTACGTATTACAGGGGGAGAACCAAGTCTTCGCAAAGATTTC
ACTGATATTATTCGTACTGTCGCCTCTCAGCCTGGTATTACTAAGGTTGCAACTACTACCAACGGTTATCGTATGGAAAA
GCACGTTGCAGAATGGAGAGAAGCAGGATTAACCGATATTAATGTGAGTGTTGATAGTTTAAATCCACATATGTTTTACC
AGATCACTGGCGAAAATAAATTTGCTGAAGTGATGGCTGGTATTGATAAAGCGCTTGAAGTTGGGTTTAAGCAAGTCAAA
GTAAATACCGTATTATTAAAAGATCTCAATAGCACCGAACTTCCTTTATTTTTAAAGTGGATTCAAACTCGCCCGATTCA
ATTGCGTTTTATTGAATTAATGCAAACGGGTGAAATGAATGACCTATTTAAAAATCACCATCAATCTGGTGTGTCTATTC
GAAATCATCTTATTGCTAATGGTTGGTTATTAAAAGCTCGTGGCGAAAGTGATGGTCCTGCGCAGGTATTTATTCATCCT
GATTACGTGGGTGAAATTGGACTTATCATGCCATATGAAAAAGATTTTTGTCAGAGCTGTAACCGACTTCGTGTGTCGGC
AAAAGGCAAGTTGCATATGTGCTTATTTGGTGATTATGGTGTAGATCTTCGTGATTTATTACAGCAAGACTCTCAACAAG
ATGAATTAATCCAACGAATTCAAACTCAGCTAGATAATAAAGCTGAAGGCCATTTTTTACATGATGGTCACGCAGGAATG
ACCCCTCATTTAGCCTCAATTGGCGGATAA

Upstream 100 bases:

>100_bases
TTTTTAAGAAGCACTCAATATGTAGCGTGAGCCAGTGACAATTCGGTCACAAGGGTTTGTTTGGAAATGAACAAGCCTCC
CGTGTTTGGAAAGGTGTTCC

Downstream 100 bases:

>100_bases
TAAAGAAGAATTATGTCAAATTTTACTCATATTAATGCCTCTGGTGAGGCAAACATGGTTGATGTTTCTGCGAAACAAGA
AACCGTTCGTGAAGCTCGTG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAQQFADNFDRKFYYLRLSVTDVCNFKCTYCLPDGYKPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDF
TDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTDINVSVDSLNPHMFYQITGENKFAEVMAGIDKALEVGFKQVK
VNTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMNDLFKNHHQSGVSIRNHLIANGWLLKARGESDGPAQVFIHP
DYVGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVDLRDLLQQDSQQDELIQRIQTQLDNKAEGHFLHDGHAGM
TPHLASIGG

Sequences:

>Translated_329_residues
MAQQFADNFDRKFYYLRLSVTDVCNFKCTYCLPDGYKPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDF
TDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTDINVSVDSLNPHMFYQITGENKFAEVMAGIDKALEVGFKQVK
VNTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMNDLFKNHHQSGVSIRNHLIANGWLLKARGESDGPAQVFIHP
DYVGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVDLRDLLQQDSQQDELIQRIQTQLDNKAEGHFLHDGHAGM
TPHLASIGG
>Mature_328_residues
AQQFADNFDRKFYYLRLSVTDVCNFKCTYCLPDGYKPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDFT
DIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTDINVSVDSLNPHMFYQITGENKFAEVMAGIDKALEVGFKQVKV
NTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMNDLFKNHHQSGVSIRNHLIANGWLLKARGESDGPAQVFIHPD
YVGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVDLRDLLQQDSQQDELIQRIQTQLDNKAEGHFLHDGHAGMT
PHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=36.0128617363344, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=36.0128617363344, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=63.2218844984802, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=35.3293413173653, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=310, Percent_Identity=36.7741935483871, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=312, Percent_Identity=37.5, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=33.1210191082803, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=33.1210191082803, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37266; Mature: 37135

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQFADNFDRKFYYLRLSVTDVCNFKCTYCLPDGYKPENGKRESFLELDEIERTVSAFA
CCCHHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RCGTSKVRITGGEPSLRKDFTDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTDI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEE
NVSVDSLNPHMFYQITGENKFAEVMAGIDKALEVGFKQVKVNTVLLKDLNSTELPLFLKW
EEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCCHHHHHH
IQTRPIQLRFIELMQTGEMNDLFKNHHQSGVSIRNHLIANGWLLKARGESDGPAQVFIHP
HHCCCCEEEEEHHHHCCCHHHHHHHHCCCCCHHHHHEEECCEEEEECCCCCCCEEEEECC
DYVGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVDLRDLLQQDSQQDELIQRI
CCCCCCCEEECCCHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHH
QTQLDNKAEGHFLHDGHAGMTPHLASIGG
HHHHCCCCCCCEEECCCCCCCCCHHCCCC
>Mature Secondary Structure 
AQQFADNFDRKFYYLRLSVTDVCNFKCTYCLPDGYKPENGKRESFLELDEIERTVSAFA
CCHHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RCGTSKVRITGGEPSLRKDFTDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTDI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEE
NVSVDSLNPHMFYQITGENKFAEVMAGIDKALEVGFKQVKVNTVLLKDLNSTELPLFLKW
EEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCCHHHHHH
IQTRPIQLRFIELMQTGEMNDLFKNHHQSGVSIRNHLIANGWLLKARGESDGPAQVFIHP
HHCCCCEEEEEHHHHCCCHHHHHHHHCCCCCHHHHHEEECCEEEEECCCCCCCEEEEECC
DYVGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVDLRDLLQQDSQQDELIQRI
CCCCCCCEEECCCHHHHHHHHHEEEECCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHH
QTQLDNKAEGHFLHDGHAGMTPHLASIGG
HHHHCCCCCCCEEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]