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The map label for this gene is serC

Identifier: 59711506

GI number: 59711506

Start: 989044

End: 990126

Strand: Direct

Name: serC

Synonym: VF_0899

Alternate gene names: 59711506

Gene position: 989044-990126 (Clockwise)

Preceding gene: 59711505

Following gene: 59711511

Centisome position: 34.13

GC content: 39.06

Gene sequence:

>1083_bases
ATGGAAAAAGTATTTAACTTTTGTGCTGGACCAGCAATGTTACCAGTAGACGTTCTCGCCCAAGCTCAAAAGGAATTGGT
AAATTGGAACGGCTTAGGCACATCTGTGATGGAAATAAGTCACCGTAGTAAAGAGTTTATTAAAGTCGCTGAAGAATCAG
AGCAAGATTTGCGTGATTTATTGGCCATTCCAGACAACTATAAAGTATTGTTTTGCCAAGGTGGTGCCAGAGCTCAGTTT
GCTGCTGTACCTTTAAATTTATTGGGCGGTAATACTAAAGCTGATTATGTTGATGCAGGTTATTGGGCTCAAAGTGCGGT
TGAAGAAGCGCAAAAATATTGTACTCCAAATGTCATTAATACCATTATTGATGTTGATGGTAAAAAAGCGGTTCAACCTG
CTTCTGAGTGGGCATTAAGCGATGATGCTGTGTATGTTCATTTTTGTCCAAATGAAACTATCGATGGAATAGAGATTAAT
GATTTACCAGTAACAGACAAACCGATTGTTGCTGATATGTCTTCAACTATCTTGTCTCGTAAAATCGATGTGTCGAAATA
CGGTGTTATTTATGCCGGAGCACAGAAGAATATTGGTCCTGCGGGCTTAACGATTGTTATTGTACGTGATGATTTATTGG
ATTTAGCCTCTCAAACACTGCCTAGTGTATTAAATTATGGCGTTTTGGCTGATAAAGAATCTATGTTCAATACGCCTCCA
ACATACGCTTGGTACCTTGCGGGATTAGTTTTCAAATGGTTGAAATCTAATGGTGGTATTGATGCAATGGAAACACACAA
CCGTAAGAAAGCAGCGGTTCTGTACGATTACATTGATCAATCTGATTTTTACCGTAACGATGTGCATTCTGATAACCGTT
CATTAATGAACGTACCATTTCAACTGGCAAACCCAGAGCTTGATACGAAGTTTCTTGAATTAGCAGATGAAGCGGGTTTA
AAAGCATTGAAAGGACACCGAGTTGTCGGTGGTATGCGTGCTTCAATTTATAATGCAATGCCATTAGAAGGTGTTGAAGC
GCTTGTGCAATTTATGAAAGAGTTTGAAGAGAAGTACGTTTAG

Upstream 100 bases:

>100_bases
GATCACTTTCTGATTCCTTTATGAGATGAAAGGTGTTATTAATTTCGTAATCATTTTTTGTCAGATAGTGTTGTAAACAT
CAACAGGAGTTTTAAGAAAC

Downstream 100 bases:

>100_bases
GTATTGCTCTTATTAACTGATACGAAAAAGCCGATATGATGATGCTCATATCGGCTTTTTTATATTCTTAGGTTATCTAT
CTAAGGTAATTAAAAGCGTT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDLLAIPDNYKVLFCQGGARAQF
AAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVINTIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEIN
DLPVTDKPIVADMSSTILSRKIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPP
TYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPFQLANPELDTKFLELADEAGL
KALKGHRVVGGMRASIYNAMPLEGVEALVQFMKEFEEKYV

Sequences:

>Translated_360_residues
MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDLLAIPDNYKVLFCQGGARAQF
AAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVINTIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEIN
DLPVTDKPIVADMSSTILSRKIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPP
TYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPFQLANPELDTKFLELADEAGL
KALKGHRVVGGMRASIYNAMPLEGVEALVQFMKEFEEKYV
>Mature_360_residues
MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDLLAIPDNYKVLFCQGGARAQF
AAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVINTIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEIN
DLPVTDKPIVADMSSTILSRKIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPP
TYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPFQLANPELDTKFLELADEAGL
KALKGHRVVGGMRASIYNAMPLEGVEALVQFMKEFEEKYV

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=366, Percent_Identity=48.6338797814208, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI10863955, Length=362, Percent_Identity=43.9226519337017, Blast_Score=292, Evalue=3e-79,
Organism=Escherichia coli, GI1787136, Length=361, Percent_Identity=68.6980609418283, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17506897, Length=371, Percent_Identity=43.1266846361186, Blast_Score=305, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=42.3376623376623, Blast_Score=269, Evalue=6e-73,
Organism=Drosophila melanogaster, GI21356589, Length=360, Percent_Identity=48.0555555555556, Blast_Score=333, Evalue=8e-92,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_VIBF1 (Q5E6F2)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204282.1
- ProteinModelPortal:   Q5E6F2
- SMR:   Q5E6F2
- STRING:   Q5E6F2
- GeneID:   3277481
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0899
- NMPDR:   fig|312309.3.peg.747
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   Q5E6F2
- ProtClustDB:   PRK05355
- BioCyc:   VFIS312309:VF0899-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39761; Mature: 39761

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 153-153 BINDING 172-172 BINDING 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDL
CCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIPDNYKVLFCQGGARAQFAAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVIN
HCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCHHHH
TIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSR
HHHCCCCCHHCCCHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHH
KIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPP
CCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCCCC
TYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPF
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEECCC
QLANPELDTKFLELADEAGLKALKGHRVVGGMRASIYNAMPLEGVEALVQFMKEFEEKYV
EECCCCHHHHHHHHHHHHCHHHHCCCCHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDL
CCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIPDNYKVLFCQGGARAQFAAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVIN
HCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCHHHH
TIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSR
HHHCCCCCHHCCCHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHH
KIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPP
CCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCCCC
TYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPF
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEECCC
QLANPELDTKFLELADEAGLKALKGHRVVGGMRASIYNAMPLEGVEALVQFMKEFEEKYV
EECCCCHHHHHHHHHHHHCHHHHCCCCHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA