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The map label for this gene is nhaA [H]

Identifier: 59711494

GI number: 59711494

Start: 974713

End: 975861

Strand: Direct

Name: nhaA [H]

Synonym: VF_0887

Alternate gene names: 59711494

Gene position: 974713-975861 (Clockwise)

Preceding gene: 59711493

Following gene: 59711495

Centisome position: 33.64

GC content: 40.82

Gene sequence:

>1149_bases
ATGAGTGATGTTATTAAGAATTTTTTCAAATTAGAATCTGCCGGTGGGATTCTGTTAGTGATCGCAGCTGCGATTGCTAT
GATGATTGCAAACTCTTCATTAGCACCAATGTACGATACATTTTTACATTCTTATATCGGTGGAATGTCAGTATCACATT
GGATTAATGACGGTCTAATGGCTGTTTTCTTCCTATTGATCGGATTAGAAGTAAAAAGAGAATTATTAGAAGGTGCGTTA
AAATCAAAAGAAACCGCTATCTTCCCTGCAATTGCAGCGGTAGGTGGTATGTTAGCGCCAGCTTTAGTTTACGTTGCATT
TAATATGGGCGATCCTGAAGCTCTATCTGGTTGGGCTATTCCTGCGGCAACAGATATTGCGTTTGCATTAGGTATCATGG
CGCTTCTTGGTAATCGAGTTCCTGTTAGCTTAAAAGTGTTCTTACTTGCACTAGCTATTATTGATGATTTAGGCGTTGTT
GTTATTATCGCTTTCTTCTACACAAGTGATCTATCTGTTCTTGCTCTTGTAATTGGTTTTGTAATGACAGGTTTACTGTT
CTTACTGAATGCAAAACATGTAACAAAGATCCGCTGGTATTTATTGGTTGGCTTTATCCTGTGGGTGAGCGTACTGCAAT
CAGGTGTTCACGCAACGTTAGCTGGTGTGGTTCTTGGTTTTGCTATCCCTCTTAAAGGCAATAAAGGTGAGCGTTCACCA
CTAAAACACATGGAACACGCATTACACCCTTATGTTGCGTTTGCTATCCTTCCTGTGTTCGCATTTGCTAATGCTGGTAT
CTCTCTAGAAGGTGTGTCACTTGATAGTTTGACGACAACATTACCTCTAGGTGTTGCTTTAGGTCTGTTCCTTGGTAAGC
CTCTAGGTATCTTCAGCTTTAGTTACCTTGCTGTTAAGTCTGGTGTAGCAAAACTACCAACAGGCGTAAACATGAAGCAT
ATTTTTGCTGTATCAGTGCTGTGTGGTATCGGCTTTACTATGTCCATCTTTATCTCATCACTGGCATTTGGTGGTGTGAA
CCCAGAGTTTGATAAACTGGCTCGCTTAGGTATCTTGATGGGCTCGACATTTGCAGCGGTTGTTGGCTATGCGTTGTTAA
GCATCTCATTACCAAAGAAAGCAGCATAA

Upstream 100 bases:

>100_bases
TGTATAAGCTCTGAACAAGCGATTATTCTTGATATTGATCAACGGGTAGACTTTTCTTATTCGTTTTTCAGTAAACCATA
ATTATAAGCAAGGACATCTT

Downstream 100 bases:

>100_bases
ACCTGTTATCTTAAAATAAGTTTTGATAAATACCTCGCAAATAGCGGGGTATTTTTTTGGACAAAAAAAAGCCCAAACAA
TAAATTGAATGGGCAAAAGG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSDVIKNFFKLESAGGILLVIAAAIAMMIANSSLAPMYDTFLHSYIGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGAL
KSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVV
VIIAFFYTSDLSVLALVIGFVMTGLLFLLNAKHVTKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGNKGERSP
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYLAVKSGVAKLPTGVNMKH
IFAVSVLCGIGFTMSIFISSLAFGGVNPEFDKLARLGILMGSTFAAVVGYALLSISLPKKAA

Sequences:

>Translated_382_residues
MSDVIKNFFKLESAGGILLVIAAAIAMMIANSSLAPMYDTFLHSYIGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGAL
KSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVV
VIIAFFYTSDLSVLALVIGFVMTGLLFLLNAKHVTKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGNKGERSP
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYLAVKSGVAKLPTGVNMKH
IFAVSVLCGIGFTMSIFISSLAFGGVNPEFDKLARLGILMGSTFAAVVGYALLSISLPKKAA
>Mature_381_residues
SDVIKNFFKLESAGGILLVIAAAIAMMIANSSLAPMYDTFLHSYIGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALK
SKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVV
IIAFFYTSDLSVLALVIGFVMTGLLFLLNAKHVTKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGNKGERSPL
KHMEHALHPYVAFAILPVFAFANAGISLEGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYLAVKSGVAKLPTGVNMKHI
FAVSVLCGIGFTMSIFISSLAFGGVNPEFDKLARLGILMGSTFAAVVGYALLSISLPKKAA

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=56.5445026178011, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40251; Mature: 40120

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVIKNFFKLESAGGILLVIAAAIAMMIANSSLAPMYDTFLHSYIGGMSVSHWINDGLM
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHH
AVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
PAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIAFFYTSDLSVLALVIGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VMTGLLFLLNAKHVTKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGNKGERSP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLDSLTTTLPLGVALGLFLGKPLGIFSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYLAVKSGVAKLPTGVNMKHIFAVSVLCGIGFTMSIFISSLAFGGVNPEFDKLARLGILM
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTFAAVVGYALLSISLPKKAA
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDVIKNFFKLESAGGILLVIAAAIAMMIANSSLAPMYDTFLHSYIGGMSVSHWINDGLM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHH
AVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
PAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIAFFYTSDLSVLALVIGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VMTGLLFLLNAKHVTKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGNKGERSP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLDSLTTTLPLGVALGLFLGKPLGIFSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYLAVKSGVAKLPTGVNMKHIFAVSVLCGIGFTMSIFISSLAFGGVNPEFDKLARLGILM
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTFAAVVGYALLSISLPKKAA
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA