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The map label for this gene is fabF [H]

Identifier: 59711467

GI number: 59711467

Start: 945651

End: 946886

Strand: Direct

Name: fabF [H]

Synonym: VF_0860

Alternate gene names: 59711467

Gene position: 945651-946886 (Clockwise)

Preceding gene: 59711466

Following gene: 59711470

Centisome position: 32.64

GC content: 42.48

Gene sequence:

>1236_bases
ATGAGTCGTCGTGTAGTCGTAACCGGAATGTCTGGTGTTACCGCTTTAGGTAGTGATTGGAACACCGTAGGCGAAAACCT
ACGTAAGTGTGAAAATGCCACTCAATATATGCCAAGCTTTGAAGTCTACGATGGTCTTAATACTAAGCTAGCAGCCCCTA
TTAATGATTTCACATTACCAAAGCACTATACCCGTAAAAAAATTCGTTCTATGGGACGTGTTTCTTTGTTATCTACCGTT
GCTTCAGAGCAAGCCTTAGAGCAAAGTGGCCTTATTGGAAATGACATCTTAACCAATGGCCAAACAGGTATTGCCTTTGG
TTCCTCAACCGGTTCTACCGATGCCGTTGGTGCTTTTGGTGTGATGCTTAATGAGAAATCAACTCGTGCTATTACGGCAA
CAACCTATGTGCAAATGATGCCACATACCGCAGCGGTTAACGTTGGTTTATTCTTTGGTTTACGTGGCCGAGTTATTCCA
ACAAGCAGCGCATGTACTTCAGGCAGCCAAGCGATTGGTTATGCTTATGAAGCGATTAAACACGGTTATCAAACGGCAAT
GGTTGCTGGTGGCGCAGAAGAATTATGCCCAACAGAATCAGCAGTATTTGATACATTATTCGCAACAAGTTTAAAAAACG
ATGCGCCAAAAACATCCCCAAGCCCATATGACCAAGATCGCGATGGTCTTGTTATTGGTGAAGGTGCTGGTGCTTTAGTT
CTTGAAGAGTATGAACATGCTAAAGCTCGTGGCGCAACGATTTACGCAGAGCTAGTTGGTTTTGCAAGTAACTGTGATGC
TGCCCATGTAACACAACCACAAATGGAAACCATGCAAATGTGTATGGAAATGTCGTTAAGGGATGCCAACTTAGCGCCAG
AGAAAATTGGTTATGTTTCAGCGCATGGTACCGCAACAGAACGTGGTGATATAGCAGAAAGTACAGCAACAGAGAACGTA
TTTGGCTCATCAATGCCAATCAGTTCATTGAAGTCTTATTTTGGTCATACATTAGGTGCATGTGGTGCGATTGAAGCGTG
GTTATCCATTGAGATGATGCGTAACAATTGGTTTAGCCCAACATTGAACTTAAATAATGTAGATGAGCGTTGCGGTAAGT
TAGATTACATTACAGGTACAGGTCGTGAAATTGAGTGTGATTACATCATGAGTAACAACTTTGCTTTTGGTGGTATTAAT
ACATCACTTATCTTTAAGCGCTGGACTGAAGAGTAG

Upstream 100 bases:

>100_bases
TGGGTGAACCAGAAGAAGTAGCCGGTTTAGTAAGTTACTTAATGTCAGATGTTGCGGGTTATGTGACTCGCCAAGTTATT
TCAATTAATGGTGGTTTAGT

Downstream 100 bases:

>100_bases
CGCTGTCTAAATAACAAATAATAAAAAACCGGTGAAGAAATTCACCGGTTTTTTTGTGTCTTTAAAAAGCAAAGCTAAAT
TAGTTTACCCAGTCACGTAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSRRVVVTGMSGVTALGSDWNTVGENLRKCENATQYMPSFEVYDGLNTKLAAPINDFTLPKHYTRKKIRSMGRVSLLSTV
ASEQALEQSGLIGNDILTNGQTGIAFGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIP
TSSACTSGSQAIGYAYEAIKHGYQTAMVAGGAEELCPTESAVFDTLFATSLKNDAPKTSPSPYDQDRDGLVIGEGAGALV
LEEYEHAKARGATIYAELVGFASNCDAAHVTQPQMETMQMCMEMSLRDANLAPEKIGYVSAHGTATERGDIAESTATENV
FGSSMPISSLKSYFGHTLGACGAIEAWLSIEMMRNNWFSPTLNLNNVDERCGKLDYITGTGREIECDYIMSNNFAFGGIN
TSLIFKRWTEE

Sequences:

>Translated_411_residues
MSRRVVVTGMSGVTALGSDWNTVGENLRKCENATQYMPSFEVYDGLNTKLAAPINDFTLPKHYTRKKIRSMGRVSLLSTV
ASEQALEQSGLIGNDILTNGQTGIAFGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIP
TSSACTSGSQAIGYAYEAIKHGYQTAMVAGGAEELCPTESAVFDTLFATSLKNDAPKTSPSPYDQDRDGLVIGEGAGALV
LEEYEHAKARGATIYAELVGFASNCDAAHVTQPQMETMQMCMEMSLRDANLAPEKIGYVSAHGTATERGDIAESTATENV
FGSSMPISSLKSYFGHTLGACGAIEAWLSIEMMRNNWFSPTLNLNNVDERCGKLDYITGTGREIECDYIMSNNFAFGGIN
TSLIFKRWTEE
>Mature_410_residues
SRRVVVTGMSGVTALGSDWNTVGENLRKCENATQYMPSFEVYDGLNTKLAAPINDFTLPKHYTRKKIRSMGRVSLLSTVA
SEQALEQSGLIGNDILTNGQTGIAFGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPT
SSACTSGSQAIGYAYEAIKHGYQTAMVAGGAEELCPTESAVFDTLFATSLKNDAPKTSPSPYDQDRDGLVIGEGAGALVL
EEYEHAKARGATIYAELVGFASNCDAAHVTQPQMETMQMCMEMSLRDANLAPEKIGYVSAHGTATERGDIAESTATENVF
GSSMPISSLKSYFGHTLGACGAIEAWLSIEMMRNNWFSPTLNLNNVDERCGKLDYITGTGREIECDYIMSNNFAFGGINT
SLIFKRWTEE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=33.4928229665072, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI223972627, Length=175, Percent_Identity=36, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI41872631, Length=279, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=38.498789346247, Blast_Score=240, Evalue=9e-65,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=33.4140435835351, Blast_Score=212, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=29.7362110311751, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=35.5805243445693, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI212642053, Length=426, Percent_Identity=27.6995305164319, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=25.7462686567164, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=32.8859060402685, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=32.4519230769231, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19920632, Length=280, Percent_Identity=26.0714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=26.0714285714286, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44152; Mature: 44021

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVVTGMSGVTALGSDWNTVGENLRKCENATQYMPSFEVYDGLNTKLAAPINDFTLP
CCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCC
KHYTRKKIRSMGRVSLLSTVASEQALEQSGLIGNDILTNGQTGIAFGSSTGSTDAVGAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEECCCCCCCCCHHHEE
VMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPTSSACTSGSQAIGYAYEAIK
EEECCCCCCEEEEEHHEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
HGYQTAMVAGGAEELCPTESAVFDTLFATSLKNDAPKTSPSPYDQDRDGLVIGEGAGALV
HCHHHEEEECCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGATIYAELVGFASNCDAAHVTQPQMETMQMCMEMSLRDANLAPEKIGYVS
EHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCEEE
AHGTATERGDIAESTATENVFGSSMPISSLKSYFGHTLGACGAIEAWLSIEMMRNNWFSP
ECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLNLNNVDERCGKLDYITGTGREIECDYIMSNNFAFGGINTSLIFKRWTEE
CCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEECCCCHHHEEEECCCC
>Mature Secondary Structure 
SRRVVVTGMSGVTALGSDWNTVGENLRKCENATQYMPSFEVYDGLNTKLAAPINDFTLP
CCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCC
KHYTRKKIRSMGRVSLLSTVASEQALEQSGLIGNDILTNGQTGIAFGSSTGSTDAVGAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEECCCCCCCCCHHHEE
VMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPTSSACTSGSQAIGYAYEAIK
EEECCCCCCEEEEEHHEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
HGYQTAMVAGGAEELCPTESAVFDTLFATSLKNDAPKTSPSPYDQDRDGLVIGEGAGALV
HCHHHEEEECCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGATIYAELVGFASNCDAAHVTQPQMETMQMCMEMSLRDANLAPEKIGYVS
EHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCEEE
AHGTATERGDIAESTATENVFGSSMPISSLKSYFGHTLGACGAIEAWLSIEMMRNNWFSP
ECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLNLNNVDERCGKLDYITGTGREIECDYIMSNNFAFGGINTSLIFKRWTEE
CCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEECCCCHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]