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The map label for this gene is ppiD [H]

Identifier: 59711407

GI number: 59711407

Start: 876376

End: 878232

Strand: Direct

Name: ppiD [H]

Synonym: VF_0800

Alternate gene names: 59711407

Gene position: 876376-878232 (Clockwise)

Preceding gene: 59711406

Following gene: 59711408

Centisome position: 30.25

GC content: 38.23

Gene sequence:

>1857_bases
ATGATGGATCGAATTCGCGAAGGTTCAACAGGCCTTGCAGTTAAGATCATTCTCGGTCTAATTATTTTCTCATTTGTATT
TGCAGGTGTAGGTAGTTATTTAGTCGGTGGTGGCCAGCCTTTAGCAGCGAAAGTTGGTGAGCGCGAAATTACTCGTAATG
AGTTTGAGCAAGTTTATCAAAATGAACGTAACCGTATGCAATCACAGTTAGGTGAATATTTTGCTACGTTACTGGGTGAT
CCTGCATATGTAGAGCAATTCCGTAAGTCAGTTTTAGACCGTATGGTTAATGATGCACTGCTTGATAACCAAGCTCAAGA
TTTAGGCTTGCGTATTAGCGATGATCAAATTCGTCAAACTATCCTTTCAATGCCTCAATTCCAAAAAGATGGCAAGTTTG
ATGAAGAAATTTATAACATTTCTTTACGCCGTGCAGGTTTTAGCTCTGATAGTTTTGCCGCTTACTTACGTCAAGACTTA
GCAAGAAACCAGCTAGTTATGGCGTTAGAATCGACAGAATTTACGTTATCAAATGAAGTTCAAGCACAAGCTGCTTTAGA
AACTCAGCAACGTGAAATTCGTACGATTACATTAAATACTGCTGATTTTGCTAAAAATGCAAAAGTAACAGATGAAGAAA
TCACAGAATACTACAATGCAAACAAACAACAATTTGTTCGACCTGAACAAGTAAAAGTGTCATATGTAGAGTTATCTGGT
AATTCATTAAAAGCGCAGGCGCCAATTACAGATAAAGAAATTGAAGAATATTACCAAGCGAATTTAGATAAATATTCTAC
ACAAGAGAAGCGTGAAGTTAGCCATATTTTAATTAAAGGCGACGAAGCTGACGCACAAAAAGTGCTAGATAGAATTAACA
ATGGCGAAGACTTTGCTACTGTAGCTAAAGATGCTTCACAAGATATCCCTACAGCTAAAGAAGGTGGTTCTTTAGGTTGG
ATTGAACGTGGTGTTATTGATCCTGAGTTTGAAGATGCTGCTTTCCAATTAGCAAAAGTTGGTGATCATTCTGGTATCGT
GAAATCAGCATTTGGTTTCCATATCATTCAACTGAATGGTATCGAAGAACCAACAACAAAACCGCTTGCTGAAGTAAGTG
CTGATATCAAGTCGTTCTTAGTTGATGAGCATGCAGCTGATGCGTTTTACAGTCTACAAACTGAACTAGCTGAAAAAGCG
TTTGAATCACCTGATTCATTAGATGATGCTGCTGAAGCGGTTGATGCGAAGATTGTAACATCTGATTTCTTCTCTCAAGC
TGATGCACCTAAAGCGCTTGCTGACTCAGCTGTACTTCAAGCTATTTATAGCCCAGAAGTTAAAGAAGATGGTTTAAACT
CTGATGTTATCGAAATTGCACCTGAACATGTTATCGTTGTTCGTGTTGAAGATGTTCGTGATGAAATGGTTTTACCTCTT
GATGAAGTAAAAGATGCAGTAATTGCTCGCTTATCTCAAGCACAAGGTGAACAGGAAGCCCTAGAACTTGCTCAAAACGT
AATTTCAGGCCTTAATAAAGGTGACAATAGCGTGATGGCAAATAATGGCTTAGCGTTTGCTGAGGCTCGAATGATCAGTC
GCAATGATGAATTAGCAAATGACGTATATCGTTTAGAGAAGCCTGCTGATGGTAAATCAACGTATGCACAGGTTATGGAT
CGTCAAGGAAACCATGTCATTGTTGCTCTTGATAGTGTATTAGAATTAAATGATTCAAATATGTCATCGCAAATTGCTAC
TGGTTTATTGCGTTCTCAAACTCAGCAAGATTTAACAGCAACGTTAGATACGCTAAAAGAAAGTACAGAAATTAGCTATC
CGTTACTTGAACAGTAA

Upstream 100 bases:

>100_bases
CTTTTGTTGAACTATTTTAAATTTTCACTATCAATAGAAATTGAAATGTTTTCTTAGGAATAAAATCATTCCATTCGGTG
ATTAGGAGTTAATACACATT

Downstream 100 bases:

>100_bases
AACATTTCTTTGTAACTGATAAATATAAAAGACGGGCCCCTATAAGGGGCCCGTCGTGTTTTTAAAGATAGAAACTATTT
CCATATAGGTTTTTAGTAAA

Product: peptidyl-prolyl cis-trans isomerase (rotamase D)

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MMDRIREGSTGLAVKIILGLIIFSFVFAGVGSYLVGGGQPLAAKVGEREITRNEFEQVYQNERNRMQSQLGEYFATLLGD
PAYVEQFRKSVLDRMVNDALLDNQAQDLGLRISDDQIRQTILSMPQFQKDGKFDEEIYNISLRRAGFSSDSFAAYLRQDL
ARNQLVMALESTEFTLSNEVQAQAALETQQREIRTITLNTADFAKNAKVTDEEITEYYNANKQQFVRPEQVKVSYVELSG
NSLKAQAPITDKEIEEYYQANLDKYSTQEKREVSHILIKGDEADAQKVLDRINNGEDFATVAKDASQDIPTAKEGGSLGW
IERGVIDPEFEDAAFQLAKVGDHSGIVKSAFGFHIIQLNGIEEPTTKPLAEVSADIKSFLVDEHAADAFYSLQTELAEKA
FESPDSLDDAAEAVDAKIVTSDFFSQADAPKALADSAVLQAIYSPEVKEDGLNSDVIEIAPEHVIVVRVEDVRDEMVLPL
DEVKDAVIARLSQAQGEQEALELAQNVISGLNKGDNSVMANNGLAFAEARMISRNDELANDVYRLEKPADGKSTYAQVMD
RQGNHVIVALDSVLELNDSNMSSQIATGLLRSQTQQDLTATLDTLKESTEISYPLLEQ

Sequences:

>Translated_618_residues
MMDRIREGSTGLAVKIILGLIIFSFVFAGVGSYLVGGGQPLAAKVGEREITRNEFEQVYQNERNRMQSQLGEYFATLLGD
PAYVEQFRKSVLDRMVNDALLDNQAQDLGLRISDDQIRQTILSMPQFQKDGKFDEEIYNISLRRAGFSSDSFAAYLRQDL
ARNQLVMALESTEFTLSNEVQAQAALETQQREIRTITLNTADFAKNAKVTDEEITEYYNANKQQFVRPEQVKVSYVELSG
NSLKAQAPITDKEIEEYYQANLDKYSTQEKREVSHILIKGDEADAQKVLDRINNGEDFATVAKDASQDIPTAKEGGSLGW
IERGVIDPEFEDAAFQLAKVGDHSGIVKSAFGFHIIQLNGIEEPTTKPLAEVSADIKSFLVDEHAADAFYSLQTELAEKA
FESPDSLDDAAEAVDAKIVTSDFFSQADAPKALADSAVLQAIYSPEVKEDGLNSDVIEIAPEHVIVVRVEDVRDEMVLPL
DEVKDAVIARLSQAQGEQEALELAQNVISGLNKGDNSVMANNGLAFAEARMISRNDELANDVYRLEKPADGKSTYAQVMD
RQGNHVIVALDSVLELNDSNMSSQIATGLLRSQTQQDLTATLDTLKESTEISYPLLEQ
>Mature_618_residues
MMDRIREGSTGLAVKIILGLIIFSFVFAGVGSYLVGGGQPLAAKVGEREITRNEFEQVYQNERNRMQSQLGEYFATLLGD
PAYVEQFRKSVLDRMVNDALLDNQAQDLGLRISDDQIRQTILSMPQFQKDGKFDEEIYNISLRRAGFSSDSFAAYLRQDL
ARNQLVMALESTEFTLSNEVQAQAALETQQREIRTITLNTADFAKNAKVTDEEITEYYNANKQQFVRPEQVKVSYVELSG
NSLKAQAPITDKEIEEYYQANLDKYSTQEKREVSHILIKGDEADAQKVLDRINNGEDFATVAKDASQDIPTAKEGGSLGW
IERGVIDPEFEDAAFQLAKVGDHSGIVKSAFGFHIIQLNGIEEPTTKPLAEVSADIKSFLVDEHAADAFYSLQTELAEKA
FESPDSLDDAAEAVDAKIVTSDFFSQADAPKALADSAVLQAIYSPEVKEDGLNSDVIEIAPEHVIVVRVEDVRDEMVLPL
DEVKDAVIARLSQAQGEQEALELAQNVISGLNKGDNSVMANNGLAFAEARMISRNDELANDVYRLEKPADGKSTYAQVMD
RQGNHVIVALDSVLELNDSNMSSQIATGLLRSQTQQDLTATLDTLKESTEISYPLLEQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=580, Percent_Identity=37.9310344827586, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1786238, Length=320, Percent_Identity=24.6875, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68358; Mature: 68358

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDRIREGSTGLAVKIILGLIIFSFVFAGVGSYLVGGGQPLAAKVGEREITRNEFEQVYQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHH
NERNRMQSQLGEYFATLLGDPAYVEQFRKSVLDRMVNDALLDNQAQDLGLRISDDQIRQT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEECHHHHHHH
ILSMPQFQKDGKFDEEIYNISLRRAGFSSDSFAAYLRQDLARNQLVMALESTEFTLSNEV
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCEEECHHH
QAQAALETQQREIRTITLNTADFAKNAKVTDEEITEYYNANKQQFVRPEQVKVSYVELSG
HHHHHHHHHHCEEEEEEEECHHHHCCCCCCHHHHHHHHCCCHHHCCCCCCEEEEEEEECC
NSLKAQAPITDKEIEEYYQANLDKYSTQEKREVSHILIKGDEADAQKVLDRINNGEDFAT
CCEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHEEEEECCCHHHHHHHHHCCCCCHHHH
VAKDASQDIPTAKEGGSLGWIERGVIDPEFEDAAFQLAKVGDHSGIVKSAFGFHIIQLNG
HHHHHHCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCEEEEEECC
IEEPTTKPLAEVSADIKSFLVDEHAADAFYSLQTELAEKAFESPDSLDDAAEAVDAKIVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SDFFSQADAPKALADSAVLQAIYSPEVKEDGLNSDVIEIAPEHVIVVRVEDVRDEMVLPL
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCHHCCCH
DEVKDAVIARLSQAQGEQEALELAQNVISGLNKGDNSVMANNGLAFAEARMISRNDELAN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCHHHHH
DVYRLEKPADGKSTYAQVMDRQGNHVIVALDSVLELNDSNMSSQIATGLLRSQTQQDLTA
HHHHHCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TLDTLKESTEISYPLLEQ
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMDRIREGSTGLAVKIILGLIIFSFVFAGVGSYLVGGGQPLAAKVGEREITRNEFEQVYQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHH
NERNRMQSQLGEYFATLLGDPAYVEQFRKSVLDRMVNDALLDNQAQDLGLRISDDQIRQT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEECHHHHHHH
ILSMPQFQKDGKFDEEIYNISLRRAGFSSDSFAAYLRQDLARNQLVMALESTEFTLSNEV
HHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCEEECHHH
QAQAALETQQREIRTITLNTADFAKNAKVTDEEITEYYNANKQQFVRPEQVKVSYVELSG
HHHHHHHHHHCEEEEEEEECHHHHCCCCCCHHHHHHHHCCCHHHCCCCCCEEEEEEEECC
NSLKAQAPITDKEIEEYYQANLDKYSTQEKREVSHILIKGDEADAQKVLDRINNGEDFAT
CCEEECCCCCHHHHHHHHHHCCHHHCCHHHHHHHEEEEECCCHHHHHHHHHCCCCCHHHH
VAKDASQDIPTAKEGGSLGWIERGVIDPEFEDAAFQLAKVGDHSGIVKSAFGFHIIQLNG
HHHHHHCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCEEEEEECC
IEEPTTKPLAEVSADIKSFLVDEHAADAFYSLQTELAEKAFESPDSLDDAAEAVDAKIVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SDFFSQADAPKALADSAVLQAIYSPEVKEDGLNSDVIEIAPEHVIVVRVEDVRDEMVLPL
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCHHCCCH
DEVKDAVIARLSQAQGEQEALELAQNVISGLNKGDNSVMANNGLAFAEARMISRNDELAN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCHHHHH
DVYRLEKPADGKSTYAQVMDRQGNHVIVALDSVLELNDSNMSSQIATGLLRSQTQQDLTA
HHHHHCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TLDTLKESTEISYPLLEQ
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]