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The map label for this gene is luxQ [H]

Identifier: 59711315

GI number: 59711315

Start: 774864

End: 777098

Strand: Direct

Name: luxQ [H]

Synonym: VF_0708

Alternate gene names: 59711315

Gene position: 774864-777098 (Clockwise)

Preceding gene: 59711314

Following gene: 59711317

Centisome position: 26.74

GC content: 30.07

Gene sequence:

>2235_bases
ATGAATAAAGGTAAAGCCTCGTTAGCGGATCTTATTTTTCGATCAATTTTTATTATATTTTCTATTTTAACAGTAGGTAT
AACCATACATACCTACCAGTTAAGTGTGAATACGATAAATGAAGAAGTTAAACGAAACTTACAACAAACTTCAGGCATAA
TTAATAATTTCTTTGAACATAGATTATCCATTCTTCAAATTAGACAAGATACTGATGCTGAAAGCCTTGCTATTTATGAC
CAATATATAGAGAGTGATTATAAAAATAAATTAAATACGTATTTTTCTAATATTGAAGCTAAATCACCTTATAATTCACC
AGATTTTAGATTTATAGAAGTAAATAATAAACTGTACTGGGATGATGGAAATAGTTCATTTTTAAGTTTAAATGAAAATT
GTCTGAAAATTATCATTAAAAAAAACCTTAATATAAACACTTGGTATTATATTAAGATGAAAGAGCCTTTATCAGAAGCT
GATTTTTTAATTAGAAAAACGCCTATAGTTAATAATGATTCAGGTAGAATTGTTGCATTCATATATAATGCAGTAATGTT
GAATAATAACATCTCATTTTTGAATAAACTTAAAAAGCTAACGAATAGCCAAGATGTATTTATTATTAATGATAATAAGA
TATTAGCATCAAGTGTAAGTTCCAATACAGAAATATATCAAGAAGTTACTTCTATTTTAAATGGCACAAGAAAAAGAATA
CCAAGTAAAATATTAAACTTTACACCTATAAATATTAAATCAATGTCAGGTGAGATATCAATATTGTCATTAAAGAATAA
AGATAATATTGAATTATTAGAGCAACGATTTATTTATAGTGTTGTTCTCTCATTTTTTGTACTTATAGCTATCGCTGTAT
TAATTCGAGGCTTATTTGAGCATAAAATACTCTTGTCATTAAATTCCTTATTAAAATACACAAATACGGTATCAAAAAAT
GAAACTCGAAGTGAGTATCAAGGTTGTGGTATTTTAGAGTTTGACCAAATTGGGGAAAAATTAGAACAGACATTTTCTGA
ATTAATTGAAGCTAAAGAAGACAGTTATAAAGCTCAAAGAGCGGCAGAAAAATTGGCACAAGTGAAATCTGACTTTTTAG
CAAGAATGAGTCATGAAATAAGAACGCCTTTAAATGGGATTTTAGGTATATCTAGCCTATTAAAGAGTAGTAACTTAACT
AGAGAGCAGCAAAAACAAGTAAATATTCTCCATCAAGGGGGAGAGCATTTGCTTGCGGTCTTAAATGATATTTTAGATTT
TTCACAGATAGAACAAGAGAAGCTAAAAATAAATAGCGCTCCTTTTAAGCTGAGTGATGTATTAGAAAATATTAATGCAA
TTTATTTTCCTCTTTGTAAAAATAAAAACGTACTTTTTTCAATTGAAAACCATGTTAATCCAGATGTATTCATTAATTCT
GATCAGGTAAGACTAACGCAGATACTTTTTAATCTACTAAGTAACGCAGCTAAATTTACAGAGAAAGGTAAAGTAAAGTT
AACCTTATCTCTTAATAAGCACAATTCCGATTATTACTTACAATTTTCGGTTGATGATACTGGGGTCGGGATCTGTGCTG
AAGAACAAACAAGAATGTTTGAGCCATTTGAACAGTCAGGTTTTTCTGAATCGAGAAAATTTGGCGGAAGTGGGTTGGGG
TTGGCTATTGTTAAGCAATTACTTGATTTGCTTAAAGGAAAAATAACAATAAACAGTACGCTAGGTGTAGGTTCTACATT
TAGCGTTCTTATTCCTGTCTTGATTTGTGAAGATAAAGCCGATATTTCAGATGCTAAAGCTGAAAATCAGATAACGTCAT
TACCAACAGGTTTAAAGATTTTATTAATTGAGGATAATAAATCGAATGCTTACATTGCTAAAGCTTATTGCCAAAAGTAT
GGACTAAATGTGACGTGGCGAAATGACGCTGCTCAAGGTATTGCTGAGCTTTCTAAATCTGAGTTTGATTTGATCTTAAT
GGATAACCAAATGCCGGGAATGAGCGGTATTAAAGCAACCAAATATATTCGTAATCATTTAAAAATAATGACACCTATTT
ATGCGTATACTGCTGATGCATTAGAGGAATCCAATCAAGAATTTTTCTCTGCAGGGGCAAACTATATTATTACTAAGCCA
ATAAAAGAAAAGTCAATACTGGATGCATTGGCTTTTTATAAATCAGAGAACGGGTTGCCACCTTTTGACTCGTAA

Upstream 100 bases:

>100_bases
ATTCTGGCGAGTTTGAACTGGTTACATCTGATACGAGTGAAGAAACACTTAATACGCTAAAACAGCGTGCGTTTCGTTAT
TCTGGTGTAGAACACTAGTA

Downstream 100 bases:

>100_bases
TTAGCTTCGCTTAACTCGAACGACTCTCATTACTTCAATATCAAAGCCTGCAATTTTTTCATTACTAGGGTAATAGGTTA
GATTAACTTTTGCTCCTTTG

Product: membrane-bound sensor histidine kinase LuxQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MNKGKASLADLIFRSIFIIFSILTVGITIHTYQLSVNTINEEVKRNLQQTSGIINNFFEHRLSILQIRQDTDAESLAIYD
QYIESDYKNKLNTYFSNIEAKSPYNSPDFRFIEVNNKLYWDDGNSSFLSLNENCLKIIIKKNLNINTWYYIKMKEPLSEA
DFLIRKTPIVNNDSGRIVAFIYNAVMLNNNISFLNKLKKLTNSQDVFIINDNKILASSVSSNTEIYQEVTSILNGTRKRI
PSKILNFTPINIKSMSGEISILSLKNKDNIELLEQRFIYSVVLSFFVLIAIAVLIRGLFEHKILLSLNSLLKYTNTVSKN
ETRSEYQGCGILEFDQIGEKLEQTFSELIEAKEDSYKAQRAAEKLAQVKSDFLARMSHEIRTPLNGILGISSLLKSSNLT
REQQKQVNILHQGGEHLLAVLNDILDFSQIEQEKLKINSAPFKLSDVLENINAIYFPLCKNKNVLFSIENHVNPDVFINS
DQVRLTQILFNLLSNAAKFTEKGKVKLTLSLNKHNSDYYLQFSVDDTGVGICAEEQTRMFEPFEQSGFSESRKFGGSGLG
LAIVKQLLDLLKGKITINSTLGVGSTFSVLIPVLICEDKADISDAKAENQITSLPTGLKILLIEDNKSNAYIAKAYCQKY
GLNVTWRNDAAQGIAELSKSEFDLILMDNQMPGMSGIKATKYIRNHLKIMTPIYAYTADALEESNQEFFSAGANYIITKP
IKEKSILDALAFYKSENGLPPFDS

Sequences:

>Translated_744_residues
MNKGKASLADLIFRSIFIIFSILTVGITIHTYQLSVNTINEEVKRNLQQTSGIINNFFEHRLSILQIRQDTDAESLAIYD
QYIESDYKNKLNTYFSNIEAKSPYNSPDFRFIEVNNKLYWDDGNSSFLSLNENCLKIIIKKNLNINTWYYIKMKEPLSEA
DFLIRKTPIVNNDSGRIVAFIYNAVMLNNNISFLNKLKKLTNSQDVFIINDNKILASSVSSNTEIYQEVTSILNGTRKRI
PSKILNFTPINIKSMSGEISILSLKNKDNIELLEQRFIYSVVLSFFVLIAIAVLIRGLFEHKILLSLNSLLKYTNTVSKN
ETRSEYQGCGILEFDQIGEKLEQTFSELIEAKEDSYKAQRAAEKLAQVKSDFLARMSHEIRTPLNGILGISSLLKSSNLT
REQQKQVNILHQGGEHLLAVLNDILDFSQIEQEKLKINSAPFKLSDVLENINAIYFPLCKNKNVLFSIENHVNPDVFINS
DQVRLTQILFNLLSNAAKFTEKGKVKLTLSLNKHNSDYYLQFSVDDTGVGICAEEQTRMFEPFEQSGFSESRKFGGSGLG
LAIVKQLLDLLKGKITINSTLGVGSTFSVLIPVLICEDKADISDAKAENQITSLPTGLKILLIEDNKSNAYIAKAYCQKY
GLNVTWRNDAAQGIAELSKSEFDLILMDNQMPGMSGIKATKYIRNHLKIMTPIYAYTADALEESNQEFFSAGANYIITKP
IKEKSILDALAFYKSENGLPPFDS
>Mature_744_residues
MNKGKASLADLIFRSIFIIFSILTVGITIHTYQLSVNTINEEVKRNLQQTSGIINNFFEHRLSILQIRQDTDAESLAIYD
QYIESDYKNKLNTYFSNIEAKSPYNSPDFRFIEVNNKLYWDDGNSSFLSLNENCLKIIIKKNLNINTWYYIKMKEPLSEA
DFLIRKTPIVNNDSGRIVAFIYNAVMLNNNISFLNKLKKLTNSQDVFIINDNKILASSVSSNTEIYQEVTSILNGTRKRI
PSKILNFTPINIKSMSGEISILSLKNKDNIELLEQRFIYSVVLSFFVLIAIAVLIRGLFEHKILLSLNSLLKYTNTVSKN
ETRSEYQGCGILEFDQIGEKLEQTFSELIEAKEDSYKAQRAAEKLAQVKSDFLARMSHEIRTPLNGILGISSLLKSSNLT
REQQKQVNILHQGGEHLLAVLNDILDFSQIEQEKLKINSAPFKLSDVLENINAIYFPLCKNKNVLFSIENHVNPDVFINS
DQVRLTQILFNLLSNAAKFTEKGKVKLTLSLNKHNSDYYLQFSVDDTGVGICAEEQTRMFEPFEQSGFSESRKFGGSGLG
LAIVKQLLDLLKGKITINSTLGVGSTFSVLIPVLICEDKADISDAKAENQITSLPTGLKILLIEDNKSNAYIAKAYCQKY
GLNVTWRNDAAQGIAELSKSEFDLILMDNQMPGMSGIKATKYIRNHLKIMTPIYAYTADALEESNQEFFSAGANYIITKP
IKEKSILDALAFYKSENGLPPFDS

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=377, Percent_Identity=32.8912466843501, Blast_Score=199, Evalue=7e-52,
Organism=Escherichia coli, GI48994928, Length=429, Percent_Identity=29.6037296037296, Blast_Score=196, Evalue=6e-51,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=41.6, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI87081816, Length=402, Percent_Identity=31.3432835820896, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=36.5758754863813, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=28.2157676348548, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788549, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=320, Percent_Identity=26.875, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=26.4367816091954, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=408, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=26.4462809917355, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=241, Percent_Identity=26.9709543568465, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1790346, Length=244, Percent_Identity=26.6393442622951, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=28.3185840707965, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789808, Length=250, Percent_Identity=22, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=76, Percent_Identity=39.4736842105263, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84032; Mature: 84032

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGKASLADLIFRSIFIIFSILTVGITIHTYQLSVNTINEEVKRNLQQTSGIINNFFEH
CCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
RLSILQIRQDTDAESLAIYDQYIESDYKNKLNTYFSNIEAKSPYNSPDFRFIEVNNKLYW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEE
DDGNSSFLSLNENCLKIIIKKNLNINTWYYIKMKEPLSEADFLIRKTPIVNNDSGRIVAF
ECCCCCEEEECHHHHEEHEECCCCCCEEEEEEECCCCCHHHHHEECCCCEECCCCCEEEE
IYNAVMLNNNISFLNKLKKLTNSQDVFIINDNKILASSVSSNTEIYQEVTSILNGTRKRI
EEEHHHCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCHHHHC
PSKILNFTPINIKSMSGEISILSLKNKDNIELLEQRFIYSVVLSFFVLIAIAVLIRGLFE
HHHHHCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKILLSLNSLLKYTNTVSKNETRSEYQGCGILEFDQIGEKLEQTFSELIEAKEDSYKAQR
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAEKLAQVKSDFLARMSHEIRTPLNGILGISSLLKSSNLTREQQKQVNILHQGGEHLLAV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LNDILDFSQIEQEKLKINSAPFKLSDVLENINAIYFPLCKNKNVLFSIENHVNPDVFINS
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEECC
DQVRLTQILFNLLSNAAKFTEKGKVKLTLSLNKHNSDYYLQFSVDDTGVGICAEEQTRMF
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEECCCHHHHC
EPFEQSGFSESRKFGGSGLGLAIVKQLLDLLKGKITINSTLGVGSTFSVLIPVLICEDKA
CCHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHEECCCC
DISDAKAENQITSLPTGLKILLIEDNKSNAYIAKAYCQKYGLNVTWRNDAAQGIAELSKS
CCCHHHHHCHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHCCC
EFDLILMDNQMPGMSGIKATKYIRNHLKIMTPIYAYTADALEESNQEFFSAGANYIITKP
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC
IKEKSILDALAFYKSENGLPPFDS
CCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNKGKASLADLIFRSIFIIFSILTVGITIHTYQLSVNTINEEVKRNLQQTSGIINNFFEH
CCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
RLSILQIRQDTDAESLAIYDQYIESDYKNKLNTYFSNIEAKSPYNSPDFRFIEVNNKLYW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEE
DDGNSSFLSLNENCLKIIIKKNLNINTWYYIKMKEPLSEADFLIRKTPIVNNDSGRIVAF
ECCCCCEEEECHHHHEEHEECCCCCCEEEEEEECCCCCHHHHHEECCCCEECCCCCEEEE
IYNAVMLNNNISFLNKLKKLTNSQDVFIINDNKILASSVSSNTEIYQEVTSILNGTRKRI
EEEHHHCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCHHHHC
PSKILNFTPINIKSMSGEISILSLKNKDNIELLEQRFIYSVVLSFFVLIAIAVLIRGLFE
HHHHHCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKILLSLNSLLKYTNTVSKNETRSEYQGCGILEFDQIGEKLEQTFSELIEAKEDSYKAQR
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAEKLAQVKSDFLARMSHEIRTPLNGILGISSLLKSSNLTREQQKQVNILHQGGEHLLAV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LNDILDFSQIEQEKLKINSAPFKLSDVLENINAIYFPLCKNKNVLFSIENHVNPDVFINS
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEECC
DQVRLTQILFNLLSNAAKFTEKGKVKLTLSLNKHNSDYYLQFSVDDTGVGICAEEQTRMF
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEECCCHHHHC
EPFEQSGFSESRKFGGSGLGLAIVKQLLDLLKGKITINSTLGVGSTFSVLIPVLICEDKA
CCHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHEECCCC
DISDAKAENQITSLPTGLKILLIEDNKSNAYIAKAYCQKYGLNVTWRNDAAQGIAELSKS
CCCHHHHHCHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHCCC
EFDLILMDNQMPGMSGIKATKYIRNHLKIMTPIYAYTADALEESNQEFFSAGANYIITKP
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC
IKEKSILDALAFYKSENGLPPFDS
CCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA