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The map label for this gene is ribB [H]

Identifier: 59711309

GI number: 59711309

Start: 769960

End: 771069

Strand: Direct

Name: ribB [H]

Synonym: VF_0702

Alternate gene names: 59711309

Gene position: 769960-771069 (Clockwise)

Preceding gene: 59711308

Following gene: 59711310

Centisome position: 26.57

GC content: 40.81

Gene sequence:

>1110_bases
ATGGCAATTAGCTCAGCAAAAGACATTATTGAAGATATTCGTTTAGGTAAGATGGTTATTCTTATGGATGACGAAGATCG
TGAGAATGAAGGTGATTTAATTATTGCCGCTGAGAAAATCACTCCTGAAGCCATTAACTTTATGGCAACTCATGGACGTG
GTTTAATCTGTTTAACGATGACAAAAGATCGTTGTGAAAAACTTGGTCTACCTCCTATGGTACAAGACAATAATGCACAA
TTTACAACGAATTTTACGGTATCAATTGAAGCGGCAGAAGGCGTAACAACCGGTATTTCAGCAGCAGACCGTTCTCGCAC
CGTTGAAGCGGCAGTAGCTAAAAATGCAGTTGCTGCAGATTTAGTTCAACCAGGGCATATTTTCCCACTAGCAGCACAAG
AAGGCGGCGTATTAACTCGTGCTGGTCATACAGAAGCTGGGTGTGATTTAGCTCGTTTAGCTGGCTATGAGCCTGCTGGT
GTGATTGTTGAAATCTTGAATGATGATGGAACAATGGCTCGTCGCCCTGATTTGGAAATTTTTGCTGAAAAACACGGCAT
TAAATTAGGTACGGTTGCTGATTTAATTGAATATCGTAATAACAACGAAACGACAATTGAACGTGTAGCTGAGTGTAAAT
TACCAACAGAGTTTGGTGAGTTTGATTTGGTGACTTACCGTGACACGATTGATAATCAACTGCACTACGCTCTTAAGAAA
GAAAATACGTCAAGTGAAGCGCCGTTAGTTCGTGTTCATTTACAAGATACATTTACTGATATTTTGCATTCAGACCGTTG
TGCAGAACGCAGCTGGACATTGCCAACAGCAATGCAGCGTATTGCCAATGAAGGTGGTGTATTAGTGATTCTTGGTAATG
AAGAATCAACAGATAGTATCGTACATAAAGTGAAAGTTCTTGAGCGTCAAGACAGTGGTGAAGCACCAACAATGGCGAAG
AAGCAAGGAACTTCACGTCGTGTAGGTGTTGGCTCTCAAATTTTGGCTGATATTGGTATTTCTGACATGCGTTTACTTTC
ATCAACGTCAAAGCGTTACCATGCCTTATCTGGCTTTGGTTTGAACGTTGTTGAATACGTAACGAAATAA

Upstream 100 bases:

>100_bases
GAGCAACCAGAGTCTTCTGTTACGATGGATCTTTTGGCAAAATCAGGCTTCTTAAATTAAGCCTCACCACTTAACCTAAT
TAATATAAAAGGTATTTCAC

Downstream 100 bases:

>100_bases
AAGCATAAATATATGGCCCTATTCGATGAGTAGGGCCTAAATAATTAGATATTTGTCACAAAGCTGTGATAGAATCCGGC
GATTCTCACTATGAATGCGT

Product: 3,4-dihydroxy-2-butanone-4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MAISSAKDIIEDIRLGKMVILMDDEDRENEGDLIIAAEKITPEAINFMATHGRGLICLTMTKDRCEKLGLPPMVQDNNAQ
FTTNFTVSIEAAEGVTTGISAADRSRTVEAAVAKNAVAADLVQPGHIFPLAAQEGGVLTRAGHTEAGCDLARLAGYEPAG
VIVEILNDDGTMARRPDLEIFAEKHGIKLGTVADLIEYRNNNETTIERVAECKLPTEFGEFDLVTYRDTIDNQLHYALKK
ENTSSEAPLVRVHLQDTFTDILHSDRCAERSWTLPTAMQRIANEGGVLVILGNEESTDSIVHKVKVLERQDSGEAPTMAK
KQGTSRRVGVGSQILADIGISDMRLLSSTSKRYHALSGFGLNVVEYVTK

Sequences:

>Translated_369_residues
MAISSAKDIIEDIRLGKMVILMDDEDRENEGDLIIAAEKITPEAINFMATHGRGLICLTMTKDRCEKLGLPPMVQDNNAQ
FTTNFTVSIEAAEGVTTGISAADRSRTVEAAVAKNAVAADLVQPGHIFPLAAQEGGVLTRAGHTEAGCDLARLAGYEPAG
VIVEILNDDGTMARRPDLEIFAEKHGIKLGTVADLIEYRNNNETTIERVAECKLPTEFGEFDLVTYRDTIDNQLHYALKK
ENTSSEAPLVRVHLQDTFTDILHSDRCAERSWTLPTAMQRIANEGGVLVILGNEESTDSIVHKVKVLERQDSGEAPTMAK
KQGTSRRVGVGSQILADIGISDMRLLSSTSKRYHALSGFGLNVVEYVTK
>Mature_368_residues
AISSAKDIIEDIRLGKMVILMDDEDRENEGDLIIAAEKITPEAINFMATHGRGLICLTMTKDRCEKLGLPPMVQDNNAQF
TTNFTVSIEAAEGVTTGISAADRSRTVEAAVAKNAVAADLVQPGHIFPLAAQEGGVLTRAGHTEAGCDLARLAGYEPAGV
IVEILNDDGTMARRPDLEIFAEKHGIKLGTVADLIEYRNNNETTIERVAECKLPTEFGEFDLVTYRDTIDNQLHYALKKE
NTSSEAPLVRVHLQDTFTDILHSDRCAERSWTLPTAMQRIANEGGVLVILGNEESTDSIVHKVKVLERQDSGEAPTMAKK
QGTSRRVGVGSQILADIGISDMRLLSSTSKRYHALSGFGLNVVEYVTK

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=191, Percent_Identity=56.5445026178011, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1787533, Length=168, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320695, Length=197, Percent_Identity=44.1624365482233, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40194; Mature: 40063

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISSAKDIIEDIRLGKMVILMDDEDRENEGDLIIAAEKITPEAINFMATHGRGLICLTM
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHEECCCCEEEEEE
TKDRCEKLGLPPMVQDNNAQFTTNFTVSIEAAEGVTTGISAADRSRTVEAAVAKNAVAAD
CHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LVQPGHIFPLAAQEGGVLTRAGHTEAGCDLARLAGYEPAGVIVEILNDDGTMARRPDLEI
HCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCHHE
FAEKHGIKLGTVADLIEYRNNNETTIERVAECKLPTEFGEFDLVTYRDTIDNQLHYALKK
EHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEECCHHCCHHEEEEEC
ENTSSEAPLVRVHLQDTFTDILHSDRCAERSWTLPTAMQRIANEGGVLVILGNEESTDSI
CCCCCCCCEEEEEEHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHH
VHKVKVLERQDSGEAPTMAKKQGTSRRVGVGSQILADIGISDMRLLSSTSKRYHALSGFG
HHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCC
LNVVEYVTK
CHHHHHHCC
>Mature Secondary Structure 
AISSAKDIIEDIRLGKMVILMDDEDRENEGDLIIAAEKITPEAINFMATHGRGLICLTM
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHEECCCCEEEEEE
TKDRCEKLGLPPMVQDNNAQFTTNFTVSIEAAEGVTTGISAADRSRTVEAAVAKNAVAAD
CHHHHHHCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LVQPGHIFPLAAQEGGVLTRAGHTEAGCDLARLAGYEPAGVIVEILNDDGTMARRPDLEI
HCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCHHE
FAEKHGIKLGTVADLIEYRNNNETTIERVAECKLPTEFGEFDLVTYRDTIDNQLHYALKK
EHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEECCHHCCHHEEEEEC
ENTSSEAPLVRVHLQDTFTDILHSDRCAERSWTLPTAMQRIANEGGVLVILGNEESTDSI
CCCCCCCCEEEEEEHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHH
VHKVKVLERQDSGEAPTMAKKQGTSRRVGVGSQILADIGISDMRLLSSTSKRYHALSGFG
HHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCCCC
LNVVEYVTK
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]