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The map label for this gene is nhaR [H]

Identifier: 59711069

GI number: 59711069

Start: 493943

End: 494833

Strand: Direct

Name: nhaR [H]

Synonym: VF_0462

Alternate gene names: 59711069

Gene position: 493943-494833 (Clockwise)

Preceding gene: 59711067

Following gene: 59711070

Centisome position: 17.05

GC content: 35.58

Gene sequence:

>891_bases
ATGTCTCATTTAAACTATAACCATCTTTATTATTTTTGGATGGTATGCAAACAAGGTTCAGTAACTAAAGCGGCTGAGGC
ATTATTTCTTACTCCTCAAACCGTAACAGGTCAAATTAAAGCCCTAGAAGATAGACTTGATGGAAAGTTAACTAAACGTA
ATGGTCGTAATATTGAGCCTACAGAGCTAGGCCAACTTATTTATAAATACGCCGATCGTATGTTTGGTTTAAGTTATGAA
ATGCTAGATATCGTTAATTATAGTCAGCAAGCAAACGTACTGTTTGATGTTGGTGTTGCTGATGCGCTTTCTAAAAGGTT
GGTTAGTAAGGTGCTTTCAACAACCGTTCCTGAAGATGCATCCATTCACTTACGTTGTTTTGAATCGACGCATGAATTAT
TACTAGAACAATTATCTCAACATAAATTGGATATGATCCTTTCAGACTGTCCTGTAGATTCAAGTCAAAATTCAGGGTTA
TTCAGTAAAAAGTTGGGTGAATGTGAGATGAGCTTTTTTTGTTCAAAAGAACTTAAAGGAGTGACATTTCCTGAGGTATT
AGAAAAACATAAGGTATTAATACCAGGTAGTCGTACTTCAATGGGAAGAAAAGTGGTTCAATGGTGCGATCAACAAGGCG
TGACTCCAAATATTTTAGGTGAGTTTGATGATGTTGCATTAATGAAAGCATTTGCTCGTGAAAATAATGCGGTTTTTTTA
GCGCCTTCCGTATATATGAATGAAGCGGATTCTGATTTATCTTTACATAAGATTGCAGATGTAAGAGATCTAAAAGAAGA
GTATTACGTCATTTTTGCAGAGAGAATGATACAGCACCCAGCGGTGAAAAGTATTTGTGAAGCAGACTTCTCGCATTTAT
TTGATTTTTAA

Upstream 100 bases:

>100_bases
TGTTTGCTATTACTGTAATAAATGACGTATCTTGCTTAGAGCAAAATAATATTAACGATTATTGCAGTAATTCAGAACAT
GAGTGATAAAAGGATTCATA

Downstream 100 bases:

>100_bases
TTTGCAATTACAGTAAGTAACAAGCTAAATTAGCCAGAGCTAAATTAGAAGGTGGGCGTCTATATGGACTTACAAATGAT
GGAAGATAATGCACCACAAG

Product: transcriptional activator NhaR

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSHLNYNHLYYFWMVCKQGSVTKAAEALFLTPQTVTGQIKALEDRLDGKLTKRNGRNIEPTELGQLIYKYADRMFGLSYE
MLDIVNYSQQANVLFDVGVADALSKRLVSKVLSTTVPEDASIHLRCFESTHELLLEQLSQHKLDMILSDCPVDSSQNSGL
FSKKLGECEMSFFCSKELKGVTFPEVLEKHKVLIPGSRTSMGRKVVQWCDQQGVTPNILGEFDDVALMKAFARENNAVFL
APSVYMNEADSDLSLHKIADVRDLKEEYYVIFAERMIQHPAVKSICEADFSHLFDF

Sequences:

>Translated_296_residues
MSHLNYNHLYYFWMVCKQGSVTKAAEALFLTPQTVTGQIKALEDRLDGKLTKRNGRNIEPTELGQLIYKYADRMFGLSYE
MLDIVNYSQQANVLFDVGVADALSKRLVSKVLSTTVPEDASIHLRCFESTHELLLEQLSQHKLDMILSDCPVDSSQNSGL
FSKKLGECEMSFFCSKELKGVTFPEVLEKHKVLIPGSRTSMGRKVVQWCDQQGVTPNILGEFDDVALMKAFARENNAVFL
APSVYMNEADSDLSLHKIADVRDLKEEYYVIFAERMIQHPAVKSICEADFSHLFDF
>Mature_295_residues
SHLNYNHLYYFWMVCKQGSVTKAAEALFLTPQTVTGQIKALEDRLDGKLTKRNGRNIEPTELGQLIYKYADRMFGLSYEM
LDIVNYSQQANVLFDVGVADALSKRLVSKVLSTTVPEDASIHLRCFESTHELLLEQLSQHKLDMILSDCPVDSSQNSGLF
SKKLGECEMSFFCSKELKGVTFPEVLEKHKVLIPGSRTSMGRKVVQWCDQQGVTPNILGEFDDVALMKAFARENNAVFLA
PSVYMNEADSDLSLHKIADVRDLKEEYYVIFAERMIQHPAVKSICEADFSHLFDF

Specific function: Plays a role in the positive regulation of nhaA (Probable) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=294, Percent_Identity=62.9251700680272, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788297, Length=244, Percent_Identity=22.5409836065574, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI157672245, Length=252, Percent_Identity=21.031746031746, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33558; Mature: 33427

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLNYNHLYYFWMVCKQGSVTKAAEALFLTPQTVTGQIKALEDRLDGKLTKRNGRNIEP
CCCCCCCCEEEEEEEECCCCHHHHHHHHEECCCHHHHHHHHHHHHHCCCEECCCCCCCCH
TELGQLIYKYADRMFGLSYEMLDIVNYSQQANVLFDVGVADALSKRLVSKVLSTTVPEDA
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC
SIHLRCFESTHELLLEQLSQHKLDMILSDCPVDSSQNSGLFSKKLGECEMSFFCSKELKG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCC
VTFPEVLEKHKVLIPGSRTSMGRKVVQWCDQQGVTPNILGEFDDVALMKAFARENNAVFL
CCHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCEEEE
APSVYMNEADSDLSLHKIADVRDLKEEYYVIFAERMIQHPAVKSICEADFSHLFDF
ECHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHLNYNHLYYFWMVCKQGSVTKAAEALFLTPQTVTGQIKALEDRLDGKLTKRNGRNIEP
CCCCCCCEEEEEEEECCCCHHHHHHHHEECCCHHHHHHHHHHHHHCCCEECCCCCCCCH
TELGQLIYKYADRMFGLSYEMLDIVNYSQQANVLFDVGVADALSKRLVSKVLSTTVPEDA
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC
SIHLRCFESTHELLLEQLSQHKLDMILSDCPVDSSQNSGLFSKKLGECEMSFFCSKELKG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCC
VTFPEVLEKHKVLIPGSRTSMGRKVVQWCDQQGVTPNILGEFDDVALMKAFARENNAVFL
CCHHHHHHHCCEECCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCEEEE
APSVYMNEADSDLSLHKIADVRDLKEEYYVIFAERMIQHPAVKSICEADFSHLFDF
ECHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]