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The map label for this gene is plsC [H]

Identifier: 59711009

GI number: 59711009

Start: 431766

End: 432527

Strand: Direct

Name: plsC [H]

Synonym: VF_0402

Alternate gene names: 59711009

Gene position: 431766-432527 (Clockwise)

Preceding gene: 59711008

Following gene: 59711010

Centisome position: 14.9

GC content: 40.29

Gene sequence:

>762_bases
ATGAAGAAGTTAGTGAGTTTAGGAGATACATTTATGATCGCATTGTTACGCCTGATTGCGTTGGCTATCTTTGCTGTCTT
TACTTTTGTGTTTGGTTGCGGTTATTGCTTATTAAGCCCTCGTAATCCAAAGCACGTTTATACTTTTGGTCGCTTATTTG
CTCGAATGTCACGTGTTTTTGGTATCAAACTAGAAATCCGTGTACCAGAGAGTGCAAAAAGTTCAGAGCCAAGTTTATAC
ATTGCGAATCACCAAAATAACTGGGATCTTTTTACTGTTTCTGGTGCTATTCAGCCAAGAACCGTAACGGTTGGTAAGAA
AAGCTTAGCTTGGATGCCATTATTTGGTCAGCTGTACTGGATTACAGGGAATATTTTGATCGACCGTAACAATCGCAGTA
AAGCGGTAGGTACGATTGCTCAAGTGGCAGAGAATATTAAAAAGCGCAATGTTTCTGTTTGGATGTTTCCTGAGGGAACA
CGTTCACGTGGACGTGGATTGTTACCATTTAAAACGGGCGCTTTTCATGCCGCTATCGCAGCGGATGTGCCTGTAACTCC
GATTGTGTGTAGTAATACTCAAGGCAACATCAAGTTAAATCGTTGGAATAATGGACATGTAATTGTTGAAATTTTGCCAC
CGATTAGCAGTGAAGGGTACGAAAAAGACAATGTGCGTGAATTAGCTAATTTGTGCCGTGAGCAGATGATTACTAAATTA
GAAGAATTAAATAAAGAAGTTGCAGAACGCAACCAAGCGTAA

Upstream 100 bases:

>100_bases
ACGCTTAATGTAAACGTATTAAAGTGGAAGCCGGGTATATTACTACCCGGTTTTTTATTGGTTGGAAATAAAGCTAATTT
GTTTATTAAAAACGATAATA

Downstream 100 bases:

>100_bases
TTAATCATCCTTAAATTTTATCTAAGGCATACGGTCTTCTGTGTGCCTTTTTCTTTTTTAGATGTGTAGACATGACAGAA
TATGTAGTTCTTGTGAATGA

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKKLVSLGDTFMIALLRLIALAIFAVFTFVFGCGYCLLSPRNPKHVYTFGRLFARMSRVFGIKLEIRVPESAKSSEPSLY
IANHQNNWDLFTVSGAIQPRTVTVGKKSLAWMPLFGQLYWITGNILIDRNNRSKAVGTIAQVAENIKKRNVSVWMFPEGT
RSRGRGLLPFKTGAFHAAIAADVPVTPIVCSNTQGNIKLNRWNNGHVIVEILPPISSEGYEKDNVRELANLCREQMITKL
EELNKEVAERNQA

Sequences:

>Translated_253_residues
MKKLVSLGDTFMIALLRLIALAIFAVFTFVFGCGYCLLSPRNPKHVYTFGRLFARMSRVFGIKLEIRVPESAKSSEPSLY
IANHQNNWDLFTVSGAIQPRTVTVGKKSLAWMPLFGQLYWITGNILIDRNNRSKAVGTIAQVAENIKKRNVSVWMFPEGT
RSRGRGLLPFKTGAFHAAIAADVPVTPIVCSNTQGNIKLNRWNNGHVIVEILPPISSEGYEKDNVRELANLCREQMITKL
EELNKEVAERNQA
>Mature_253_residues
MKKLVSLGDTFMIALLRLIALAIFAVFTFVFGCGYCLLSPRNPKHVYTFGRLFARMSRVFGIKLEIRVPESAKSSEPSLY
IANHQNNWDLFTVSGAIQPRTVTVGKKSLAWMPLFGQLYWITGNILIDRNNRSKAVGTIAQVAENIKKRNVSVWMFPEGT
RSRGRGLLPFKTGAFHAAIAADVPVTPIVCSNTQGNIKLNRWNNGHVIVEILPPISSEGYEKDNVRELANLCREQMITKL
EELNKEVAERNQA

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=223, Percent_Identity=33.1838565022422, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI15100175, Length=223, Percent_Identity=33.1838565022422, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI6041665, Length=241, Percent_Identity=28.6307053941909, Blast_Score=120, Evalue=9e-28,
Organism=Escherichia coli, GI1789395, Length=242, Percent_Identity=62.396694214876, Blast_Score=320, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17564032, Length=194, Percent_Identity=33.5051546391753, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17568319, Length=260, Percent_Identity=29.6153846153846, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320151, Length=246, Percent_Identity=34.1463414634146, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281364648, Length=228, Percent_Identity=32.4561403508772, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24582856, Length=228, Percent_Identity=32.4561403508772, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24582854, Length=228, Percent_Identity=32.4561403508772, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24641614, Length=203, Percent_Identity=35.9605911330049, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24641612, Length=203, Percent_Identity=35.9605911330049, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 28364; Mature: 28364

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVSLGDTFMIALLRLIALAIFAVFTFVFGCGYCLLSPRNPKHVYTFGRLFARMSRVF
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHH
GIKLEIRVPESAKSSEPSLYIANHQNNWDLFTVSGAIQPRTVTVGKKSLAWMPLFGQLYW
EEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCEEEEEHHCEEEE
ITGNILIDRNNRSKAVGTIAQVAENIKKRNVSVWMFPEGTRSRGRGLLPFKTGAFHAAIA
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEE
ADVPVTPIVCSNTQGNIKLNRWNNGHVIVEILPPISSEGYEKDNVRELANLCREQMITKL
CCCCCCCEEECCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
EELNKEVAERNQA
HHHHHHHHHHCCC
>Mature Secondary Structure
MKKLVSLGDTFMIALLRLIALAIFAVFTFVFGCGYCLLSPRNPKHVYTFGRLFARMSRVF
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHH
GIKLEIRVPESAKSSEPSLYIANHQNNWDLFTVSGAIQPRTVTVGKKSLAWMPLFGQLYW
EEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCEEEEEHHCEEEE
ITGNILIDRNNRSKAVGTIAQVAENIKKRNVSVWMFPEGTRSRGRGLLPFKTGAFHAAIA
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEE
ADVPVTPIVCSNTQGNIKLNRWNNGHVIVEILPPISSEGYEKDNVRELANLCREQMITKL
CCCCCCCEEECCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
EELNKEVAERNQA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]