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The map label for this gene is fklB [H]

Identifier: 59710921

GI number: 59710921

Start: 323634

End: 324254

Strand: Reverse

Name: fklB [H]

Synonym: VF_0314

Alternate gene names: 59710921

Gene position: 324254-323634 (Counterclockwise)

Preceding gene: 59710923

Following gene: 59710920

Centisome position: 11.19

GC content: 44.61

Gene sequence:

>621_bases
ATGTCTGAAGTAAAATTAGAAACAGTAGAACAAAGAGCAAGCTACGGTATTGGTCTTCAAATGGGCCAGCAACTAGCACA
ATCAGGTCTTGAAGGCCTAAACGTTGCTGCTATCGCTAAAGGTATCGCAACTTCACTAACTGGTGATATGCCAGAAATCG
AAGTTGACGCTATCAACGAAGCACTTCAAGCACTTCACATGCGTGCTGAAGAAGCTCGTGCAGAAGCTTCAAAAGCTGCT
GCAGCTGAAGGCGAAGCTTTCCTAGCTGATAACGCACTTCGTCCAGAAGTAACTGTACTAGAGTCAGGCCTTCAATATGA
AGTACTAACTGAAGGTACTGGTGAAATTCCAACTTCTGATAAAACAGTACGTGTTCACTACCACGGTATGCTAACTAACG
GTGCTGTATTCGATAGCTCTGTAGAACGTGGCCAACCTGCTGAATTCCCAGTAACTGGCGTTATCGCTGGTTGGGTTGAA
GCTCTTCAACTAATGCCTGTAGGTTCTAAGTGGAAACTTTCTATTCCACAAAACCTAGCATACGGTGAGCGTGGCGCTGG
TGCTGCAATCCCTCCATATGCTGCTCTAGTATTTGAAGTTGAACTACTAGATATCCTTTAA

Upstream 100 bases:

>100_bases
TCTAATATCAGAGTTCAAAGAAGTACAAAAGTTTACCTTAAGCTTAGATCTCTGTATCCTTTATGCTTTCGTTTATACCA
TATAAAGAAAGAGAGACTGT

Downstream 100 bases:

>100_bases
TCTTTCTCAAAAAAGGTTAAATATAAAATTAAAAAGCGATGCCTATGGGTATCGCTTTTTTTTGTGTCATACTCTAACTA
CAATGTTACAAAAACAATAT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEEARAEASKAA
AAEGEAFLADNALRPEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTNGAVFDSSVERGQPAEFPVTGVIAGWVE
ALQLMPVGSKWKLSIPQNLAYGERGAGAAIPPYAALVFEVELLDIL

Sequences:

>Translated_206_residues
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEEARAEASKAA
AAEGEAFLADNALRPEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTNGAVFDSSVERGQPAEFPVTGVIAGWVE
ALQLMPVGSKWKLSIPQNLAYGERGAGAAIPPYAALVFEVELLDIL
>Mature_205_residues
SEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEEARAEASKAAA
AEGEAFLADNALRPEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTNGAVFDSSVERGQPAEFPVTGVIAGWVEA
LQLMPVGSKWKLSIPQNLAYGERGAGAAIPPYAALVFEVELLDIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=44.3396226415094, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=44.3396226415094, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=40.5660377358491, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=52.9411764705882, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=52.9411764705882, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=52.9411764705882, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4503729, Length=101, Percent_Identity=40.5940594059406, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI192448443, Length=88, Percent_Identity=43.1818181818182, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=58.252427184466, Blast_Score=244, Evalue=3e-66,
Organism=Escherichia coli, GI1789745, Length=214, Percent_Identity=35.0467289719626, Blast_Score=107, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=43.5294117647059, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=40, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=86, Percent_Identity=54.6511627906977, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=41.8181818181818, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363946, Length=87, Percent_Identity=48.2758620689655, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17352457, Length=87, Percent_Identity=48.2758620689655, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=42.4528301886792, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=39.622641509434, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647110, Length=94, Percent_Identity=43.6170212765958, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21791; Mature: 21660

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINE
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
ALQALHMRAEEARAEASKAAAAEGEAFLADNALRPEVTVLESGLQYEVLTEGTGEIPTSD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCEEEEEECCCCCCCCCC
KTVRVHYHGMLTNGAVFDSSVERGQPAEFPVTGVIAGWVEALQLMPVGSKWKLSIPQNLA
CEEEEEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
YGERGAGAAIPPYAALVFEVELLDIL
CCCCCCCCCCCCHHHHHEEHHHHHCC
>Mature Secondary Structure 
SEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINE
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
ALQALHMRAEEARAEASKAAAAEGEAFLADNALRPEVTVLESGLQYEVLTEGTGEIPTSD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCEEEEEECCCCCCCCCC
KTVRVHYHGMLTNGAVFDSSVERGQPAEFPVTGVIAGWVEALQLMPVGSKWKLSIPQNLA
CEEEEEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
YGERGAGAAIPPYAALVFEVELLDIL
CCCCCCCCCCCCHHHHHEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]