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The map label for this gene is pepQ [H]

Identifier: 59710645

GI number: 59710645

Start: 46035

End: 47828

Strand: Reverse

Name: pepQ [H]

Synonym: VF_0038

Alternate gene names: 59710645

Gene position: 47828-46035 (Counterclockwise)

Preceding gene: 172087633

Following gene: 59710644

Centisome position: 1.65

GC content: 41.75

Gene sequence:

>1794_bases
ATGCACCCACAAACTTCTCAGCGTGTTGAACAACTACGAACATGGCTTGCTCAACAAGATTTCGATGCCTTAATTATTCC
TCATGAAGATGAATTTCTAGGTGAATATATTCCAGAGCATAACGAACGTTTGCATTGGGTTACTGGTTTTACTGGTTCTG
CCGGCGCCGCTGTTATTACTAAAGAAAAAGCGGCTATTTTTGTTGATGGTCGTTATACCGTTCAAGTTCGTAAACAAGTG
CCTGCAGATGTATTTGAATATCGTCACCTACATGAAGAACCACTGCTTGAATGGATTAAAGACAGTCTGACTTCGGGTTC
AAAAGTGGCAATAGACCCACGCATGCACACAGCTCAATGGCTAAAAACAGCATCAAAAAATGTTGAAGGCGTTGTAACTC
TTGAAGCTATCGCCACTAACCCTATTGATGAATTATGGTTAGACCGTCCAGAAGTTAAAGTGTCTGATGTGCGTTTAATG
TCATTAGAATTTGTCGGAAAAAGTTCTGAAGACAAGCGTAAAGAAATTGCAAAAGAAGTCTCAAAGAAAAAAGCTGACGC
AGCGCTATTAACACAACTAGACTCCATCTGTTGGTTATTGAATATCCGTGGTTTGGATGTCTCTCGCCTACCAGTGCTTC
TTTCTCATGCCATTATTCATGCAGATGAAAGTGTTGATTTTTTCCTAGAACCTTCACGTCTTCCTGCAGAGTTTAATGCT
CATGTTGGCCAGGGTGTTCGAGTTCACCAACCAGATGCCCTGCAAGAAACATTAGAATCACTTGCAGGTAAAAAAGTTCT
GGTTGATTCAGCAACATCAAACGCATGGATGTCATTAGTCTTAAGTAATGCGAACGCACAAATCATTGAAGCATCTGATC
CATGTTTACTACCAAAAGCCGCTAAAAACGAAACGGAAAAAGCAGGCATGCGTGCTTGTCATGTTCGTGATGGCGCAGCT
ATGGCTAAATTCCTAACTTGGTTTGACGCAGAAATTGAAGCTGGCAACCTACATGACGAAGCTGTGTTAGCTGACAAACT
TCAAGCGTTCCGTGAAGAAGATGCCTCTCTGGCTGATTTAAGTTTCGATACTATTTCTGCAGCTGCTGGTAATGCGGCAA
TGTGTCACTACAATCATCAAAACCAACCTGAACCAGGTAAGCTACAAATGAACAGTTTATACCTAGTTGATTCAGGCGGT
CAGTATCCAGATGGTACAACAGACATCACTCGAACATTAGCGGTTGGTACACCAAGTGATGACATTAAACAGCAATTTAC
TTTGGTTCTTAAAGGCCATATCGGGTTAGCAAATGCTCGCTTCCCTAAAGGTACATGTGGGCATCAATTAGACATTCTTG
CTCGCCAACATTTATGGGCGCAAGGTTATGATTATGATCATGGTACTGGCCACGGTGTTGGTCACTTCTTAAGTGTCCAT
GAAGGTCCTCAACGTATTGCTAAAGTAGTAAATAATACAGCTCTTCTTCCTGGAATGGTGCTTTCTAATGAGCCTGGTTA
TTATCGTGCAGACGAGTTTGGTATCCGTATTGAGAACTTAGAGCTAGTCGTTGAAATTGAAACTCAAGGTGACTTCTCGG
TTCTTGGATTTGAGTCTTTAACACGTTGTCCTATCGACAAACGTCTGATCAATGTTGATATGCTAAATCGCCCAGAGTTA
GCGTGGTTGAATAACTATCATCAGAAAGTCTGGAATGAAGTTAGCCCTCTTGTTGATGGCGAAGTAAAAGAATGGCTTAA
ACAAGCGACCGCTGAATTAAGCTACGAAAGCTAA

Upstream 100 bases:

>100_bases
GCTAGGTTATAACTCTACAAAAAACATAACTAATTTCTTTCTGCCTCGTACACACGGACAGAGTCATACCAATTAATCAC
AGGTATAAAAGGACACTCAG

Downstream 100 bases:

>100_bases
TTCATTAAAATACAACAATAAAATGCCACGTATTTACGTGGCATTTTTTTAGTAAAAAATATATGTTCCACGTGAAACAT
GGTTACAGTTCAAATTTATT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MHPQTSQRVEQLRTWLAQQDFDALIIPHEDEFLGEYIPEHNERLHWVTGFTGSAGAAVITKEKAAIFVDGRYTVQVRKQV
PADVFEYRHLHEEPLLEWIKDSLTSGSKVAIDPRMHTAQWLKTASKNVEGVVTLEAIATNPIDELWLDRPEVKVSDVRLM
SLEFVGKSSEDKRKEIAKEVSKKKADAALLTQLDSICWLLNIRGLDVSRLPVLLSHAIIHADESVDFFLEPSRLPAEFNA
HVGQGVRVHQPDALQETLESLAGKKVLVDSATSNAWMSLVLSNANAQIIEASDPCLLPKAAKNETEKAGMRACHVRDGAA
MAKFLTWFDAEIEAGNLHDEAVLADKLQAFREEDASLADLSFDTISAAAGNAAMCHYNHQNQPEPGKLQMNSLYLVDSGG
QYPDGTTDITRTLAVGTPSDDIKQQFTLVLKGHIGLANARFPKGTCGHQLDILARQHLWAQGYDYDHGTGHGVGHFLSVH
EGPQRIAKVVNNTALLPGMVLSNEPGYYRADEFGIRIENLELVVEIETQGDFSVLGFESLTRCPIDKRLINVDMLNRPEL
AWLNNYHQKVWNEVSPLVDGEVKEWLKQATAELSYES

Sequences:

>Translated_597_residues
MHPQTSQRVEQLRTWLAQQDFDALIIPHEDEFLGEYIPEHNERLHWVTGFTGSAGAAVITKEKAAIFVDGRYTVQVRKQV
PADVFEYRHLHEEPLLEWIKDSLTSGSKVAIDPRMHTAQWLKTASKNVEGVVTLEAIATNPIDELWLDRPEVKVSDVRLM
SLEFVGKSSEDKRKEIAKEVSKKKADAALLTQLDSICWLLNIRGLDVSRLPVLLSHAIIHADESVDFFLEPSRLPAEFNA
HVGQGVRVHQPDALQETLESLAGKKVLVDSATSNAWMSLVLSNANAQIIEASDPCLLPKAAKNETEKAGMRACHVRDGAA
MAKFLTWFDAEIEAGNLHDEAVLADKLQAFREEDASLADLSFDTISAAAGNAAMCHYNHQNQPEPGKLQMNSLYLVDSGG
QYPDGTTDITRTLAVGTPSDDIKQQFTLVLKGHIGLANARFPKGTCGHQLDILARQHLWAQGYDYDHGTGHGVGHFLSVH
EGPQRIAKVVNNTALLPGMVLSNEPGYYRADEFGIRIENLELVVEIETQGDFSVLGFESLTRCPIDKRLINVDMLNRPEL
AWLNNYHQKVWNEVSPLVDGEVKEWLKQATAELSYES
>Mature_597_residues
MHPQTSQRVEQLRTWLAQQDFDALIIPHEDEFLGEYIPEHNERLHWVTGFTGSAGAAVITKEKAAIFVDGRYTVQVRKQV
PADVFEYRHLHEEPLLEWIKDSLTSGSKVAIDPRMHTAQWLKTASKNVEGVVTLEAIATNPIDELWLDRPEVKVSDVRLM
SLEFVGKSSEDKRKEIAKEVSKKKADAALLTQLDSICWLLNIRGLDVSRLPVLLSHAIIHADESVDFFLEPSRLPAEFNA
HVGQGVRVHQPDALQETLESLAGKKVLVDSATSNAWMSLVLSNANAQIIEASDPCLLPKAAKNETEKAGMRACHVRDGAA
MAKFLTWFDAEIEAGNLHDEAVLADKLQAFREEDASLADLSFDTISAAAGNAAMCHYNHQNQPEPGKLQMNSLYLVDSGG
QYPDGTTDITRTLAVGTPSDDIKQQFTLVLKGHIGLANARFPKGTCGHQLDILARQHLWAQGYDYDHGTGHGVGHFLSVH
EGPQRIAKVVNNTALLPGMVLSNEPGYYRADEFGIRIENLELVVEIETQGDFSVLGFESLTRCPIDKRLINVDMLNRPEL
AWLNNYHQKVWNEVSPLVDGEVKEWLKQATAELSYES

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=628, Percent_Identity=37.5796178343949, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI93141226, Length=605, Percent_Identity=34.5454545454545, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI264681565, Length=627, Percent_Identity=36.0446570972887, Blast_Score=350, Evalue=2e-96,
Organism=Escherichia coli, GI1788728, Length=331, Percent_Identity=28.7009063444109, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17509539, Length=591, Percent_Identity=33.6717428087986, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25149105, Length=591, Percent_Identity=32.1489001692047, Blast_Score=271, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6322999, Length=662, Percent_Identity=31.1178247734139, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17137632, Length=618, Percent_Identity=35.4368932038835, Blast_Score=336, Evalue=3e-92,
Organism=Drosophila melanogaster, GI161078230, Length=582, Percent_Identity=29.0378006872852, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21357287, Length=582, Percent_Identity=29.0378006872852, Blast_Score=251, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66409; Mature: 66409

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPQTSQRVEQLRTWLAQQDFDALIIPHEDEFLGEYIPEHNERLHWVTGFTGSAGAAVIT
CCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
KEKAAIFVDGRYTVQVRKQVPADVFEYRHLHEEPLLEWIKDSLTSGSKVAIDPRMHTAQW
ECCEEEEECCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHHH
LKTASKNVEGVVTLEAIATNPIDELWLDRPEVKVSDVRLMSLEFVGKSSEDKRKEIAKEV
HHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCEECCEEEEEEEECCCCCHHHHHHHHHHH
SKKKADAALLTQLDSICWLLNIRGLDVSRLPVLLSHAIIHADESVDFFLEPSRLPAEFNA
HHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHCH
HVGQGVRVHQPDALQETLESLAGKKVLVDSATSNAWMSLVLSNANAQIIEASDPCLLPKA
HCCCCEEECCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCEEEECCCCEECCCH
AKNETEKAGMRACHVRDGAAMAKFLTWFDAEIEAGNLHDEAVLADKLQAFREEDASLADL
HCCCHHHHCCEEEECCCHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEC
SFDTISAAAGNAAMCHYNHQNQPEPGKLQMNSLYLVDSGGQYPDGTTDITRTLAVGTPSD
CHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHEEEEECCCCH
DIKQQFTLVLKGHIGLANARFPKGTCGHQLDILARQHLWAQGYDYDHGTGHGVGHFLSVH
HHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECC
EGPQRIAKVVNNTALLPGMVLSNEPGYYRADEFGIRIENLELVVEIETQGDFSVLGFESL
CCHHHHHHHHCCCCCCCCEEECCCCCCEECHHHCEEEECEEEEEEEECCCCEEEECHHHH
TRCPIDKRLINVDMLNRPELAWLNNYHQKVWNEVSPLVDGEVKEWLKQATAELSYES
HCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHPQTSQRVEQLRTWLAQQDFDALIIPHEDEFLGEYIPEHNERLHWVTGFTGSAGAAVIT
CCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
KEKAAIFVDGRYTVQVRKQVPADVFEYRHLHEEPLLEWIKDSLTSGSKVAIDPRMHTAQW
ECCEEEEECCEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHHH
LKTASKNVEGVVTLEAIATNPIDELWLDRPEVKVSDVRLMSLEFVGKSSEDKRKEIAKEV
HHHHCCCCCEEEEEEEECCCCHHHHHCCCCCCEECCEEEEEEEECCCCCHHHHHHHHHHH
SKKKADAALLTQLDSICWLLNIRGLDVSRLPVLLSHAIIHADESVDFFLEPSRLPAEFNA
HHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHCH
HVGQGVRVHQPDALQETLESLAGKKVLVDSATSNAWMSLVLSNANAQIIEASDPCLLPKA
HCCCCEEECCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCEEEECCCCEECCCH
AKNETEKAGMRACHVRDGAAMAKFLTWFDAEIEAGNLHDEAVLADKLQAFREEDASLADL
HCCCHHHHCCEEEECCCHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEC
SFDTISAAAGNAAMCHYNHQNQPEPGKLQMNSLYLVDSGGQYPDGTTDITRTLAVGTPSD
CHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHEEEEECCCCH
DIKQQFTLVLKGHIGLANARFPKGTCGHQLDILARQHLWAQGYDYDHGTGHGVGHFLSVH
HHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECC
EGPQRIAKVVNNTALLPGMVLSNEPGYYRADEFGIRIENLELVVEIETQGDFSVLGFESL
CCHHHHHHHHCCCCCCCCEEECCCCCCEECHHHCEEEECEEEEEEEECCCCEEEECHHHH
TRCPIDKRLINVDMLNRPELAWLNNYHQKVWNEVSPLVDGEVKEWLKQATAELSYES
HCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]