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The map label for this gene is pyrH

Identifier: 58617481

GI number: 58617481

Start: 1199267

End: 1200001

Strand: Reverse

Name: pyrH

Synonym: ERGA_CDS_07540

Alternate gene names: 58617481

Gene position: 1200001-1199267 (Counterclockwise)

Preceding gene: 58617482

Following gene: 58617480

Centisome position: 80.0

GC content: 36.19

Gene sequence:

>735_bases
ATGAGTGAAAACTCTGCTAATGAGCTTAAATACTCGAGAGTTTTACTAAAAGTATCTGGTGAAGCATTAATGGGAGATAA
AGGCTTTGGGTGGGATATTGAAACTATTGATAATCTATCACATGACCTTAAGGAAGTACATGATCTTGGTGTACAGTTAT
GTTTAGTTGTAGGTGGTGGTAATATATTTCGTGGTGCTTCTGCTTCTGCACCTTTTGGTTTTGAGAGGGCTAGTAATGAT
TATATAGGCATGTTAGCTACTATGATGAATGCACTGTCTTTACAAAACTCTTTAGAAAAAATAAATGTACAATCTAGAGT
CTTGTCTGCAGTTTCTATTACTGCAGTATGTGAGACATATATTAGGAGGCGTGCTATCCGTCATTTAGAGAAGGGAAGAA
TAGTTATTTGTGCAGCTGGGGTAGGTAATCCTTTTTTTACTACAGATACTGCTGCTGCTTTACGTGGCATAGAAATGGGA
TGTAATGTGATATTTAAAGGGACGCAAGTTGATGGTGTCTACTCAGCAGATCCTAAAAAAGTTGCTGATGCAGTTAGGTA
TGATAAGATTTCTTATCGTGAGTTATTATCTCTTGATCTTAAAATTATGGATGTTGCAGCTGTATCCTTGGCTCGAGATC
ATTCAATTCCTATTATTGTGTTTAATCTAGGTAAACGTGGTGCACTTGCTGATATAATCTGTGGTGGTGGTTTGTATACA
ACAATATATAATTAA

Upstream 100 bases:

>100_bases
ATAATGGGTTTTGGTTATGATAAATTGTATATTGCATCTTTTTATTGCTAATTATATAATTAACCGTGTCTATAATTGTT
AGATGATAAAAGGAAAGTAA

Downstream 100 bases:

>100_bases
GATTTAATAGAAATAGTTGGTATAATAAGATGATTAATACAATAAAGCAAGATGCTAAGAATAGAATGGAGAAGACATTA
TCGGTATATTTAAGTGATGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGGNIFRGASASAPFGFERASND
YIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETYIRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMG
CNVIFKGTQVDGVYSADPKKVADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYT
TIYN

Sequences:

>Translated_244_residues
MSENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGGNIFRGASASAPFGFERASND
YIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETYIRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMG
CNVIFKGTQVDGVYSADPKKVADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYT
TIYN
>Mature_243_residues
SENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGGNIFRGASASAPFGFERASNDY
IGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETYIRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMGC
NVIFKGTQVDGVYSADPKKVADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYTT
IYN

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=225, Percent_Identity=48.8888888888889, Blast_Score=235, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_EHRRG (Q5FG65)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196680.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q5FG65
- SMR:   Q5FG65
- STRING:   Q5FG65
- GeneID:   3268175
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_07540
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   ERUM302409:ERGA_CDS_07540-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26370; Mature: 26239

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: BINDING 59-59 BINDING 60-60 BINDING 64-64 BINDING 80-80 BINDING 168-168 BINDING 169-169 BINDING 174-174 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGG
CCCCCCHHHHHHEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECC
NIFRGASASAPFGFERASNDYIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETY
CEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMGCNVIFKGTQVDGVYSADPKK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCEECCEECCCHHH
VADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYT
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEEECCCEEE
TIYN
EECC
>Mature Secondary Structure 
SENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGG
CCCCCHHHHHHEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECC
NIFRGASASAPFGFERASNDYIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETY
CEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMGCNVIFKGTQVDGVYSADPKK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCEECCEECCCHHH
VADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYT
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEEECCCEEE
TIYN
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA