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The map label for this gene is fabH

Identifier: 58617319

GI number: 58617319

Start: 963176

End: 964135

Strand: Reverse

Name: fabH

Synonym: ERGA_CDS_05920

Alternate gene names: 58617319

Gene position: 964135-963176 (Counterclockwise)

Preceding gene: 58617320

Following gene: 58617316

Centisome position: 64.28

GC content: 34.06

Gene sequence:

>960_bases
ATGAGAAGGTCTAGGATATTGGGAATAGGTTCTTATTTACCTAAAAGTTTGGTGACAAATGATGAGCTTGCTTGTACTGT
TGAAACGAGTGATGAATGGATAGTCAAAAGGACTGGTATTAGACAGAGATATATTGCTGCAGATGATCAAATGACATCAG
ATATGGCTGTAGAGGCAGCAAAACTTGCTTTGAATGATTCGGGTATTAATAAACAGGATGTTGATTTAATTGTTGTTGCT
ACTACTACACCAGATAGGACATTTCCTAGTTGTGCTACTATAGTTCAGTCTAAGTTGGAGTGTAAGAATGCTTTTGCGTT
TGATATTCAGGCTGTTTGTTCTGGGTTCATATATGCTATGGCTATTGCTGATAATTTTATAAAATCTGGTCAGGTTAATG
TGTCACTTGTAATAGGGGCTGAAGTAATGTCTAGAATTTTAGATTGGAAGGATAGGTCTACATGTGTATTATTTGGTGAT
GGTGCAGGTGCAGTTGTTTTAAGTAATAATTCTGCACGAAATACTGGTGTTATATCTACTATTTTGTATTCTGATGGAAC
TCTTCATAATTTATTGTATACAAGTGGTGGTACAGCATACAATGGTGTTGCAGGTACAATATGTATGAATGGTACAGTTG
TGTTTGAACATGCAATTGAAAAATTAAGTGCTTCTATAGTTGAAATTCTAAATAAAAATAATTTGAGCATAGATGAGGTT
AACTGGTTTGTATTGCATCAAGCTAATATTCGTATCATTGAATTAGTAGCAAGAAGGTTAAAAATACCTTCTGAGAAAAT
GGTAATTAGTATTAATCAACATGCTAACACATCTGCAGCTTCAATACCATTAGCATTATCTTATGCAAAAAATTCAGGAA
AGTTAAAACAAGATGATCTTGTTATTTTGGCAGCAATAGGTGCTGGTATTACTTGGGGTGTATGTTTAGTGAGAATGTAG

Upstream 100 bases:

>100_bases
TTAGCTTTTGCTAATGCTGTAAAAGTAGTTGTCAATGCTGTAATTCATGATATTAATGCTAAGATTGTTCATGAGTTGAA
TTAAAGATAGTGTTATTTAA

Downstream 100 bases:

>100_bases
TATTATATAAATTCTATTACTCTAATGACAAGACTAGATCGTATGTAAAAAATGAAAAATTCAAGTTATGTGTTATAAAT
AGTAAGTATTATTAGTATTA

Product: 3-oxoacyl-[acyl carrier protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRRSRILGIGSYLPKSLVTNDELACTVETSDEWIVKRTGIRQRYIAADDQMTSDMAVEAAKLALNDSGINKQDVDLIVVA
TTTPDRTFPSCATIVQSKLECKNAFAFDIQAVCSGFIYAMAIADNFIKSGQVNVSLVIGAEVMSRILDWKDRSTCVLFGD
GAGAVVLSNNSARNTGVISTILYSDGTLHNLLYTSGGTAYNGVAGTICMNGTVVFEHAIEKLSASIVEILNKNNLSIDEV
NWFVLHQANIRIIELVARRLKIPSEKMVISINQHANTSAASIPLALSYAKNSGKLKQDDLVILAAIGAGITWGVCLVRM

Sequences:

>Translated_319_residues
MRRSRILGIGSYLPKSLVTNDELACTVETSDEWIVKRTGIRQRYIAADDQMTSDMAVEAAKLALNDSGINKQDVDLIVVA
TTTPDRTFPSCATIVQSKLECKNAFAFDIQAVCSGFIYAMAIADNFIKSGQVNVSLVIGAEVMSRILDWKDRSTCVLFGD
GAGAVVLSNNSARNTGVISTILYSDGTLHNLLYTSGGTAYNGVAGTICMNGTVVFEHAIEKLSASIVEILNKNNLSIDEV
NWFVLHQANIRIIELVARRLKIPSEKMVISINQHANTSAASIPLALSYAKNSGKLKQDDLVILAAIGAGITWGVCLVRM
>Mature_319_residues
MRRSRILGIGSYLPKSLVTNDELACTVETSDEWIVKRTGIRQRYIAADDQMTSDMAVEAAKLALNDSGINKQDVDLIVVA
TTTPDRTFPSCATIVQSKLECKNAFAFDIQAVCSGFIYAMAIADNFIKSGQVNVSLVIGAEVMSRILDWKDRSTCVLFGD
GAGAVVLSNNSARNTGVISTILYSDGTLHNLLYTSGGTAYNGVAGTICMNGTVVFEHAIEKLSASIVEILNKNNLSIDEV
NWFVLHQANIRIIELVARRLKIPSEKMVISINQHANTSAASIPLALSYAKNSGKLKQDDLVILAAIGAGITWGVCLVRM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=44.794952681388, Blast_Score=276, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_EHRRG (Q5FFP2)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196518.1
- HSSP:   P0A6R0
- ProteinModelPortal:   Q5FFP2
- SMR:   Q5FFP2
- STRING:   Q5FFP2
- GeneID:   3268409
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_05920
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   TACIVQQ
- ProtClustDB:   CLSK749163
- BioCyc:   ERUM302409:ERGA_CDS_05920-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34423; Mature: 34423

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSRILGIGSYLPKSLVTNDELACTVETSDEWIVKRTGIRQRYIAADDQMTSDMAVEAA
CCCCEEEECHHHCCHHHCCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHHHHH
KLALNDSGINKQDVDLIVVATTTPDRTFPSCATIVQSKLECKNAFAFDIQAVCSGFIYAM
HEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AIADNFIKSGQVNVSLVIGAEVMSRILDWKDRSTCVLFGDGAGAVVLSNNSARNTGVIST
HHHHHHHHCCCEEEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEE
ILYSDGTLHNLLYTSGGTAYNGVAGTICMNGTVVFEHAIEKLSASIVEILNKNNLSIDEV
EEECCCCEEEEEEECCCCEECCCEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCEEHE
NWFVLHQANIRIIELVARRLKIPSEKMVISINQHANTSAASIPLALSYAKNSGKLKQDDL
EEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCE
VILAAIGAGITWGVCLVRM
EEEEECCCCCEEEEEEEEC
>Mature Secondary Structure
MRRSRILGIGSYLPKSLVTNDELACTVETSDEWIVKRTGIRQRYIAADDQMTSDMAVEAA
CCCCEEEECHHHCCHHHCCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHHHHH
KLALNDSGINKQDVDLIVVATTTPDRTFPSCATIVQSKLECKNAFAFDIQAVCSGFIYAM
HEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AIADNFIKSGQVNVSLVIGAEVMSRILDWKDRSTCVLFGDGAGAVVLSNNSARNTGVIST
HHHHHHHHCCCEEEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEE
ILYSDGTLHNLLYTSGGTAYNGVAGTICMNGTVVFEHAIEKLSASIVEILNKNNLSIDEV
EEECCCCEEEEEEECCCCEECCCEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCEEHE
NWFVLHQANIRIIELVARRLKIPSEKMVISINQHANTSAASIPLALSYAKNSGKLKQDDL
EEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCE
VILAAIGAGITWGVCLVRM
EEEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA