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The map label for this gene is nrdA [H]

Identifier: 58617310

GI number: 58617310

Start: 947573

End: 949360

Strand: Reverse

Name: nrdA [H]

Synonym: ERGA_CDS_05830

Alternate gene names: 58617310

Gene position: 949360-947573 (Counterclockwise)

Preceding gene: 58617313

Following gene: 58617309

Centisome position: 63.29

GC content: 32.49

Gene sequence:

>1788_bases
ATGGGATCAGTAATTGTTGATTACGAAAGGGATAATAACCTGACAGTTTTTGGTAAGGCTGTATTATCTGATAGGTATTT
GCTAGAAAATGAAGATTATCAACAATTATTTGTAAGAATTTCTGAGTATTATGCAGATAATTCAGAGCATGCGCAAAGGT
TATATGATTACATGAGTAAGCTATGGTTTATGCCTGCTACTCCAATATTGAGTAATGGTGGTACAAATAGAGGGTTACCG
GTTTCGTGTTTTTTAAATGAAACGGAAGATAGTTTAAAAGGTATTGTTGATTTATGGAATGAAAATGTATGGTTAGCTTC
AAAAGGTGGAGGAATAGGTAGCTATTGGGGTAATTTACGATCTATAGGTGAGAAAGTTCGTGGTAGTGGAAAAACTTCAG
GGATTATACCGTTTATTGTAGTACAAAATGCTTTAACTTTAGCAATTAGTCAGGGGTCTTTGCGACGTGGGAGTTCTGCT
GTATACCTACCGGTTTGGCATCCAGAAATTGAGGAGTTTTTAGATTTAAGAAAGCCTACAGGTGGTGATCCTAATAGAAA
AGCGTTAAATATACATCATGGGGTAGTATTATCAGATCATTTTATGAAGTGTGTTGAAAATGATGCAATGTGGGATTTAA
TTAGCCCTAAGGATCAATCTGTTATTTTTACTGTAAAAGCACGTGATATTTGGATAAAGATTTTAACTGCCAGAGTTGAA
ACTGGTGAACCATATATATTGTTTATTGATCATGTTAATCGTAATAAACCAGAGATTTATCAAAAACTAAATTTGGATAT
AAAAATGTCTAACTTATGTACTGAGATAACTCTTGCTACTGGATATGATCACTTGAATAAGTCTCGTACAGCTATATGTT
GTCTTTCATCATTAAATCTTGAGTATTATGAGCACTGGAAAGATAATGAGTTATTTATAGAAGATGTAATGAGATTTCTT
GATAATGTATTGACTGATTTTATAGAGAAAGCTCCTAATGAAATGGAAAGAGCAAAATATTCAGCTATGCGTGAGCGTAG
TATAGGAGTTGGAGTTATGGGTTTTCACTCATTTTTGCAAAGTAAAATGATTCCTTTTGAATCGGTAGCAGCTACTATAT
GGAACAAAAAGATATTTTCTCATATAAAAAAACATGCTGATGCTGCATCATATAGAATTGCTATAGAAAAAGGGCCTTGT
CCTGATGCTAAGGATGCTGGTGTTATGGAAAGGTTTGTTAATAAATTATCTATTGCTCCTACTGCATCTATTTCAATTAT
TGCTGGGAATACATCTCCTGGAATTGAACCTTACGCAGCTAATGTTTTTACCCATAAAACTTTAACTGGCTCTTTTATTG
TACGAAATAAATTTTTACAAAAACTCTTAATATTAAAAGGTGAGAATAATGATCAAGTTTGGTCTACCATTTCAACTAAT
GAAGGTTCAGTTCAACATTTAGATTTTTTAACTGATACAGAAAAGTTAGTATTTAAAACTGCATATGAGCTTGATCAAAG
GTGGATAATAGAGCATAGTAGTGATAGATCAAAATACATATGTCAGGCACAATCTGTTAATATTTTTCTACCTGCTAATG
TACATAAGAGGTATTTACATAAAATACATTTTCTTGCATGGAAAAAAGGCTTAAAAAGTTTATATTACTCTAGGTCAAAG
TCAATTCAGCGTGCAGATAAAGTGTCTCGTGGTGCACTTGAAAAATCAATTGAGCAGTGTAAACAGATAACAAATTTTGA
TTATGATGAATGTTTATCATGTCAGTAA

Upstream 100 bases:

>100_bases
ATATTGTGTTTTACATAATAGACAAATACAATATATATTATATGGACAATATTTTTGATAGTATGTATAAGATTTATGGA
CGAAAAATAAGGTAAAAATT

Downstream 100 bases:

>100_bases
TATTGATGAATTAATTAACATGTTAAAATTATAGACGACCTATATAAGTAATCAATTTTTATAATAGCATACTAAATAGT
CAGGTATTTTGATGAGTAAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MGSVIVDYERDNNLTVFGKAVLSDRYLLENEDYQQLFVRISEYYADNSEHAQRLYDYMSKLWFMPATPILSNGGTNRGLP
VSCFLNETEDSLKGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSA
VYLPVWHPEIEEFLDLRKPTGGDPNRKALNIHHGVVLSDHFMKCVENDAMWDLISPKDQSVIFTVKARDIWIKILTARVE
TGEPYILFIDHVNRNKPEIYQKLNLDIKMSNLCTEITLATGYDHLNKSRTAICCLSSLNLEYYEHWKDNELFIEDVMRFL
DNVLTDFIEKAPNEMERAKYSAMRERSIGVGVMGFHSFLQSKMIPFESVAATIWNKKIFSHIKKHADAASYRIAIEKGPC
PDAKDAGVMERFVNKLSIAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQKLLILKGENNDQVWSTISTN
EGSVQHLDFLTDTEKLVFKTAYELDQRWIIEHSSDRSKYICQAQSVNIFLPANVHKRYLHKIHFLAWKKGLKSLYYSRSK
SIQRADKVSRGALEKSIEQCKQITNFDYDECLSCQ

Sequences:

>Translated_595_residues
MGSVIVDYERDNNLTVFGKAVLSDRYLLENEDYQQLFVRISEYYADNSEHAQRLYDYMSKLWFMPATPILSNGGTNRGLP
VSCFLNETEDSLKGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSA
VYLPVWHPEIEEFLDLRKPTGGDPNRKALNIHHGVVLSDHFMKCVENDAMWDLISPKDQSVIFTVKARDIWIKILTARVE
TGEPYILFIDHVNRNKPEIYQKLNLDIKMSNLCTEITLATGYDHLNKSRTAICCLSSLNLEYYEHWKDNELFIEDVMRFL
DNVLTDFIEKAPNEMERAKYSAMRERSIGVGVMGFHSFLQSKMIPFESVAATIWNKKIFSHIKKHADAASYRIAIEKGPC
PDAKDAGVMERFVNKLSIAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQKLLILKGENNDQVWSTISTN
EGSVQHLDFLTDTEKLVFKTAYELDQRWIIEHSSDRSKYICQAQSVNIFLPANVHKRYLHKIHFLAWKKGLKSLYYSRSK
SIQRADKVSRGALEKSIEQCKQITNFDYDECLSCQ
>Mature_594_residues
GSVIVDYERDNNLTVFGKAVLSDRYLLENEDYQQLFVRISEYYADNSEHAQRLYDYMSKLWFMPATPILSNGGTNRGLPV
SCFLNETEDSLKGIVDLWNENVWLASKGGGIGSYWGNLRSIGEKVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSAV
YLPVWHPEIEEFLDLRKPTGGDPNRKALNIHHGVVLSDHFMKCVENDAMWDLISPKDQSVIFTVKARDIWIKILTARVET
GEPYILFIDHVNRNKPEIYQKLNLDIKMSNLCTEITLATGYDHLNKSRTAICCLSSLNLEYYEHWKDNELFIEDVMRFLD
NVLTDFIEKAPNEMERAKYSAMRERSIGVGVMGFHSFLQSKMIPFESVAATIWNKKIFSHIKKHADAASYRIAIEKGPCP
DAKDAGVMERFVNKLSIAPTASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQKLLILKGENNDQVWSTISTNE
GSVQHLDFLTDTEKLVFKTAYELDQRWIIEHSSDRSKYICQAQSVNIFLPANVHKRYLHKIHFLAWKKGLKSLYYSRSKS
IQRADKVSRGALEKSIEQCKQITNFDYDECLSCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=625, Percent_Identity=32.32, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1789030, Length=626, Percent_Identity=27.4760383386581, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI2367133, Length=441, Percent_Identity=26.530612244898, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17555242, Length=662, Percent_Identity=32.3262839879154, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6320914, Length=657, Percent_Identity=31.3546423135464, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322123, Length=633, Percent_Identity=31.2796208530806, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17352481, Length=622, Percent_Identity=30.2250803858521, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 67708; Mature: 67577

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSVIVDYERDNNLTVFGKAVLSDRYLLENEDYQQLFVRISEYYADNSEHAQRLYDYMSK
CCCEEEEEECCCCEEEEEHHHHCCCCEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LWFMPATPILSNGGTNRGLPVSCFLNETEDSLKGIVDLWNENVWLASKGGGIGSYWGNLR
HHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
SIGEKVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSAVYLPVWHPEIEEFLDLRKPT
HHHHHHCCCCCCCCCCHHEECCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHCCCC
GGDPNRKALNIHHGVVLSDHFMKCVENDAMWDLISPKDQSVIFTVKARDIWIKILTARVE
CCCCCCCEEEEECCEEEHHHHHHHHCCCCCEECCCCCCCEEEEEEEEHHEEEEEEEEEEC
TGEPYILFIDHVNRNKPEIYQKLNLDIKMSNLCTEITLATGYDHLNKSRTAICCLSSLNL
CCCCEEEEEECCCCCCHHHHHHHCCCEEEHHHHEEEEEECCCHHHCCCCCEEEEHHHCCC
EYYEHWKDNELFIEDVMRFLDNVLTDFIEKAPNEMERAKYSAMRERSIGVGVMGFHSFLQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
SKMIPFESVAATIWNKKIFSHIKKHADAASYRIAIEKGPCPDAKDAGVMERFVNKLSIAP
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
TASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQKLLILKGENNDQVWSTISTN
CCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECC
EGSVQHLDFLTDTEKLVFKTAYELDQRWIIEHSSDRSKYICQAQSVNIFLPANVHKRYLH
CCCEEEEHHHCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEECCCHHHHHHH
KIHFLAWKKGLKSLYYSRSKSIQRADKVSRGALEKSIEQCKQITNFDYDECLSCQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
GSVIVDYERDNNLTVFGKAVLSDRYLLENEDYQQLFVRISEYYADNSEHAQRLYDYMSK
CCEEEEEECCCCEEEEEHHHHCCCCEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LWFMPATPILSNGGTNRGLPVSCFLNETEDSLKGIVDLWNENVWLASKGGGIGSYWGNLR
HHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
SIGEKVRGSGKTSGIIPFIVVQNALTLAISQGSLRRGSSAVYLPVWHPEIEEFLDLRKPT
HHHHHHCCCCCCCCCCHHEECCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHCCCC
GGDPNRKALNIHHGVVLSDHFMKCVENDAMWDLISPKDQSVIFTVKARDIWIKILTARVE
CCCCCCCEEEEECCEEEHHHHHHHHCCCCCEECCCCCCCEEEEEEEEHHEEEEEEEEEEC
TGEPYILFIDHVNRNKPEIYQKLNLDIKMSNLCTEITLATGYDHLNKSRTAICCLSSLNL
CCCCEEEEEECCCCCCHHHHHHHCCCEEEHHHHEEEEEECCCHHHCCCCCEEEEHHHCCC
EYYEHWKDNELFIEDVMRFLDNVLTDFIEKAPNEMERAKYSAMRERSIGVGVMGFHSFLQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
SKMIPFESVAATIWNKKIFSHIKKHADAASYRIAIEKGPCPDAKDAGVMERFVNKLSIAP
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCC
TASISIIAGNTSPGIEPYAANVFTHKTLTGSFIVRNKFLQKLLILKGENNDQVWSTISTN
CCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECC
EGSVQHLDFLTDTEKLVFKTAYELDQRWIIEHSSDRSKYICQAQSVNIFLPANVHKRYLH
CCCEEEEHHHCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEECCCHHHHHHH
KIHFLAWKKGLKSLYYSRSKSIQRADKVSRGALEKSIEQCKQITNFDYDECLSCQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]