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The map label for this gene is lpd [H]

Identifier: 58617255

GI number: 58617255

Start: 841669

End: 843093

Strand: Reverse

Name: lpd [H]

Synonym: ERGA_CDS_05280

Alternate gene names: 58617255

Gene position: 843093-841669 (Counterclockwise)

Preceding gene: 58617256

Following gene: 58617254

Centisome position: 56.21

GC content: 32.21

Gene sequence:

>1425_bases
TTGATAAAAAAGTATAGGAAGAAGTGTATGCAAAATTATGATGTAGTAGTTATTGGTGGAGGACCTGGAGGGTATAAGTG
TGCGATTAGGAGTGCTCAGCTTGGTTTAAAGGTTGCATGTGTAGATAAAAATGAGATCCTAGGTGGTACTTGTTTAAGAG
TTGGTTGTATTCCTTCAAAAGCTTTGTTACATTTTTCTCATGAGTATTATCACATCAAAAATCATCTCGATGAAGTTGGA
ATAACTTGTAATAGTTTGAGTTTCAATTTAGATAAAATTATGTCCTTTAAAAATAAGAACATTACTGAATTAGGTAATGG
GATTAATTATTTGTTTGCTAGTAATAAAATTGATAGGTTATGTGGTGTTGGTAAGATAAGATCTATAAACTCTAACAATT
TTGATATTACAGTTACTGGAAATAATGGTGAAGAGAAAATAACTGCTAAATATGTTGTTATTGCTACTGGATCTGAAGTT
GCAAGTTTTCCTGGTATTGAGATTGATGAAAATAATGTTGTGTCTTCTACAGCTGCTTTATCATTTAAAGAAGTTCCTAA
AAAATTGGTAGTTGTTGGTGCTGGGGCTATAGGATTAGAAATGTCCTCTGTATGGAGTAGGTTTGGTTCTGAAGTTACAG
TGGTTGAGTTTCTTGATAAAATTGCTCCTAGTATGGATATAGATATAAGTAAAGCACTACTTGCTAGTTTGAAAAAGCAA
GGAATTAATTTTAAATTATCAACGAAAGTCACCTCTATAGATAAAAGTTCAGATAATTTAACAATACATCTTGAATCTGT
AAAAGATGGAAAATCTGAAATTATAGAAGCAGAAAAGGTTCTTATATCCATTGGGCGTATTCCATATACTGATGGATTGA
TTGACCAAAATTGCATAGAATGTGATTCTAGAGGGTTTATTAAGGTTAACAATAAATATGAAACTAATATACCAGGGATT
TTTGCTATTGGCGATGTAATTGGTGGAGCAATGCTTGCTCATAAAGCAGAAGAGGAAGGGATTGCTGTGGCAGAATTGAT
TGCTGGAAACATTCCTCATGTAGATTATGATATTATTCCATCTGTTATATATACACATCCTGCTGTTGCATCTATTGGTA
AAACAGAGGAGAGTTTAAAAAATATTAATTATGCATACAATGTGGGTAAATCTAATTTTTCTGCAAATAGTAGGTCAAAA
ATTACAAATAATGGAGAAGGATTTGTTAAAGTTCTTACTTCTAAAGAAAATAATGCAATATTAGGTGTACATATAATTGG
CGCATATGCTGATACTATCATTAATGAAGCAGCTATTGCTATGGCTTATCGTGCATCATCGGAAGATGTGTTTCGTATTT
CCCATTCTCATCCAGATGTAAATGAAGCATTTAAGGATGCATGTGAGGCAGCGTATTTGAAATAA

Upstream 100 bases:

>100_bases
TTAAAATCAGTAAATTATATATTACCATCATCTTATTATGTACCAATATTTCTCAATTCTTCAGTGTACATTATTACAAG
TAAGGATAAGGTAGTTATTT

Downstream 100 bases:

>100_bases
ATAAGTGTTTTAATTTAGGTATGTTTTATGTTACAGAAACTCTTAGGTTTGCAGCTGCAGCATAAAATAGCATGTTTCAT
AATATTATTAGCTGTTATTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MIKKYRKKCMQNYDVVVIGGGPGGYKCAIRSAQLGLKVACVDKNEILGGTCLRVGCIPSKALLHFSHEYYHIKNHLDEVG
ITCNSLSFNLDKIMSFKNKNITELGNGINYLFASNKIDRLCGVGKIRSINSNNFDITVTGNNGEEKITAKYVVIATGSEV
ASFPGIEIDENNVVSSTAALSFKEVPKKLVVVGAGAIGLEMSSVWSRFGSEVTVVEFLDKIAPSMDIDISKALLASLKKQ
GINFKLSTKVTSIDKSSDNLTIHLESVKDGKSEIIEAEKVLISIGRIPYTDGLIDQNCIECDSRGFIKVNNKYETNIPGI
FAIGDVIGGAMLAHKAEEEGIAVAELIAGNIPHVDYDIIPSVIYTHPAVASIGKTEESLKNINYAYNVGKSNFSANSRSK
ITNNGEGFVKVLTSKENNAILGVHIIGAYADTIINEAAIAMAYRASSEDVFRISHSHPDVNEAFKDACEAAYLK

Sequences:

>Translated_474_residues
MIKKYRKKCMQNYDVVVIGGGPGGYKCAIRSAQLGLKVACVDKNEILGGTCLRVGCIPSKALLHFSHEYYHIKNHLDEVG
ITCNSLSFNLDKIMSFKNKNITELGNGINYLFASNKIDRLCGVGKIRSINSNNFDITVTGNNGEEKITAKYVVIATGSEV
ASFPGIEIDENNVVSSTAALSFKEVPKKLVVVGAGAIGLEMSSVWSRFGSEVTVVEFLDKIAPSMDIDISKALLASLKKQ
GINFKLSTKVTSIDKSSDNLTIHLESVKDGKSEIIEAEKVLISIGRIPYTDGLIDQNCIECDSRGFIKVNNKYETNIPGI
FAIGDVIGGAMLAHKAEEEGIAVAELIAGNIPHVDYDIIPSVIYTHPAVASIGKTEESLKNINYAYNVGKSNFSANSRSK
ITNNGEGFVKVLTSKENNAILGVHIIGAYADTIINEAAIAMAYRASSEDVFRISHSHPDVNEAFKDACEAAYLK
>Mature_474_residues
MIKKYRKKCMQNYDVVVIGGGPGGYKCAIRSAQLGLKVACVDKNEILGGTCLRVGCIPSKALLHFSHEYYHIKNHLDEVG
ITCNSLSFNLDKIMSFKNKNITELGNGINYLFASNKIDRLCGVGKIRSINSNNFDITVTGNNGEEKITAKYVVIATGSEV
ASFPGIEIDENNVVSSTAALSFKEVPKKLVVVGAGAIGLEMSSVWSRFGSEVTVVEFLDKIAPSMDIDISKALLASLKKQ
GINFKLSTKVTSIDKSSDNLTIHLESVKDGKSEIIEAEKVLISIGRIPYTDGLIDQNCIECDSRGFIKVNNKYETNIPGI
FAIGDVIGGAMLAHKAEEEGIAVAELIAGNIPHVDYDIIPSVIYTHPAVASIGKTEESLKNINYAYNVGKSNFSANSRSK
ITNNGEGFVKVLTSKENNAILGVHIIGAYADTIINEAAIAMAYRASSEDVFRISHSHPDVNEAFKDACEAAYLK

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=50.2155172413793, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=27.0967741935484, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=24.3010752688172, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI33519430, Length=460, Percent_Identity=25.6521739130435, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33519428, Length=460, Percent_Identity=25.6521739130435, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33519426, Length=460, Percent_Identity=25.6521739130435, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI148277065, Length=460, Percent_Identity=25.6521739130435, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI148277071, Length=460, Percent_Identity=25.6521739130435, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI291045266, Length=485, Percent_Identity=25.979381443299, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI291045268, Length=478, Percent_Identity=25.3138075313808, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI226437568, Length=142, Percent_Identity=30.9859154929577, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21389617, Length=142, Percent_Identity=30.9859154929577, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI65787454, Length=143, Percent_Identity=31.4685314685315, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=36.980306345733, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=29.3103448275862, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789915, Length=445, Percent_Identity=28.0898876404494, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081717, Length=467, Percent_Identity=27.1948608137045, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=52.03426124197, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=26.4033264033264, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=352, Percent_Identity=27.5568181818182, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=352, Percent_Identity=27.5568181818182, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=496, Percent_Identity=25.2016129032258, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=233, Percent_Identity=26.6094420600858, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=47.6793248945148, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=33.4038054968288, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=28.2978723404255, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=50.8658008658009, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=26.2939958592132, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=26.5010351966874, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=26.5010351966874, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=26.0780287474333, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 51246; Mature: 51246

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKYRKKCMQNYDVVVIGGGPGGYKCAIRSAQLGLKVACVDKNEILGGTCLRVGCIPSK
CCHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCH
ALLHFSHEYYHIKNHLDEVGITCNSLSFNLDKIMSFKNKNITELGNGINYLFASNKIDRL
HHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHCCCCHHHHCCCEEEEEECCCHHHH
CGVGKIRSINSNNFDITVTGNNGEEKITAKYVVIATGSEVASFPGIEIDENNVVSSTAAL
HCCCCEEECCCCCEEEEEECCCCCCEEEEEEEEEEECCCHHHCCCCEECCCCEECHHHHH
SFKEVPKKLVVVGAGAIGLEMSSVWSRFGSEVTVVEFLDKIAPSMDIDISKALLASLKKQ
HHHHCCCEEEEEECCHHHCCHHHHHHHHCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHC
GINFKLSTKVTSIDKSSDNLTIHLESVKDGKSEIIEAEKVLISIGRIPYTDGLIDQNCIE
CCCEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHC
CDSRGFIKVNNKYETNIPGIFAIGDVIGGAMLAHKAEEEGIAVAELIAGNIPHVDYDIIP
CCCCCEEEECCEEECCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHH
SVIYTHPAVASIGKTEESLKNINYAYNVGKSNFSANSRSKITNNGEGFVKVLTSKENNAI
HHHHCCCHHHHCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
LGVHIIGAYADTIINEAAIAMAYRASSEDVFRISHSHPDVNEAFKDACEAAYLK
EEEEEEHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKKYRKKCMQNYDVVVIGGGPGGYKCAIRSAQLGLKVACVDKNEILGGTCLRVGCIPSK
CCHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCH
ALLHFSHEYYHIKNHLDEVGITCNSLSFNLDKIMSFKNKNITELGNGINYLFASNKIDRL
HHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHCCCCHHHHCCCEEEEEECCCHHHH
CGVGKIRSINSNNFDITVTGNNGEEKITAKYVVIATGSEVASFPGIEIDENNVVSSTAAL
HCCCCEEECCCCCEEEEEECCCCCCEEEEEEEEEEECCCHHHCCCCEECCCCEECHHHHH
SFKEVPKKLVVVGAGAIGLEMSSVWSRFGSEVTVVEFLDKIAPSMDIDISKALLASLKKQ
HHHHCCCEEEEEECCHHHCCHHHHHHHHCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHC
GINFKLSTKVTSIDKSSDNLTIHLESVKDGKSEIIEAEKVLISIGRIPYTDGLIDQNCIE
CCCEEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHC
CDSRGFIKVNNKYETNIPGIFAIGDVIGGAMLAHKAEEEGIAVAELIAGNIPHVDYDIIP
CCCCCEEEECCEEECCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHH
SVIYTHPAVASIGKTEESLKNINYAYNVGKSNFSANSRSKITNNGEGFVKVLTSKENNAI
HHHHCCCHHHHCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
LGVHIIGAYADTIINEAAIAMAYRASSEDVFRISHSHPDVNEAFKDACEAAYLK
EEEEEEHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]