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The map label for this gene is nuoF [H]

Identifier: 58617220

GI number: 58617220

Start: 797536

End: 798813

Strand: Reverse

Name: nuoF [H]

Synonym: ERGA_CDS_04930

Alternate gene names: 58617220

Gene position: 798813-797536 (Counterclockwise)

Preceding gene: 58617221

Following gene: 58617219

Centisome position: 53.26

GC content: 35.6

Gene sequence:

>1278_bases
ATGTTAGAAGATAAAGACAAAGTTTTTACTAACCTTAGTGGCCAAGGTTCTCCATTTTTAAAAGCTGCAAAAAGTAGAGG
TATCTGGAGTAATATCTTAGATATATTAAATTTAGGCTCAGAACACATTATTCAAGAAGTAAAAAAATCTGGATTACGTG
GTAGGGGTGGTGCAGGTTTTTCTACAGGACTTAAGTGGAGTTTTATGCCAAAAACCAGAAAGGAAGGACAGCCAGCGTAT
TTGGTTGTTAATGCGGATGAGTCGGAACCTGGTACATGTAAAGATCGTGATATATTAAGGTATGAACCACATAGGCTTAT
TGAAGGAATATTAATAGCTGGGTTTGCTATGAGGGTGACTACAGCTTATATTTATATTCGTGGTGAATTTTATAATGAGT
ATTTAATATTATCTGAGGCACTTAAAGAGGCATATAAAGCAAAATTAATTGGTAAAAATGCATGTAAGTCTGGTTATGAC
ATAGATATATTTATTCATAGAGGTGCTGGTGCATATATTTGTGGGGAGGAAACTGCTCAGCTTGAATCTTTGGAAGGTAG
AAAAGGGATGCCAAGGTTAAAACCACCATTTCCTGCTGCAATAGGATTATATGGATGTCCTACTACGATTAATAATGTTG
AAACTATTGCAACCATTGGTGAAATTTTAAGAAGAGGTAGTAATTGGTTTGCATCTCTTGGAAAGGAGAATAATACTGGT
ACTAAAATCTTCTGCATATCAGGACATGTTAATAATCCGTGTAATGTAGAAGAGGAATTAGGTATTCCTATGAGAGAGTT
AATAGAGAAATATGCAGGAGGTGTTCGTGGTGGATGGGATAATTTATTAGCAGTAATACCAGGGGGTTCTTCAGTTCCTG
TGCTTCCAAAATCTATTTGTGATACTATTACTATGGATTTCGATTCTTTAAGGGCTGTACAATCTGGTTTGGGTACTGCA
GGTTTGATAGTGATGGATAAATCAACAGATATAATTGCAGCTATAGAAAGGTTATCACATTTTTACATGCATGAATCTTG
TGGGCAGTGTACACCATGCCGTGAGGGTACTGGTTGGATGTGGAAAATCATGAGGAAGCTAGTAAAAGGAACTGCTACAT
ATGATGATATTGATTTATTATTAAGTATTAGTTATCAGATAGAAGGACATACAATTTGTGCTCTTGGTGATGCTGCAGCT
TGGCCAGTACAAGGTTTAATTAGACATTTTAGAGGTGTTATTGAAGAGAGAATAGATAATTGTATTAGAAAATCATAG

Upstream 100 bases:

>100_bases
AGATAACAGTTATATAGTTTTAATATGTGGAATCAATATGTTTATATTGGATGTCTGTTTTTTAATTTCCAATTTTTAGT
TCTTGTTTATTTAAAGCTTT

Downstream 100 bases:

>100_bases
AAAAAATAACATATCTATTTCATACAATATAGGTGAGATACAATATCATTTATAACAATCTTTTAATTAGTTTTTAGAGA
ACAATTTTTCTTCTCATTAC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLEDKDKVFTNLSGQGSPFLKAAKSRGIWSNILDILNLGSEHIIQEVKKSGLRGRGGAGFSTGLKWSFMPKTRKEGQPAY
LVVNADESEPGTCKDRDILRYEPHRLIEGILIAGFAMRVTTAYIYIRGEFYNEYLILSEALKEAYKAKLIGKNACKSGYD
IDIFIHRGAGAYICGEETAQLESLEGRKGMPRLKPPFPAAIGLYGCPTTINNVETIATIGEILRRGSNWFASLGKENNTG
TKIFCISGHVNNPCNVEEELGIPMRELIEKYAGGVRGGWDNLLAVIPGGSSVPVLPKSICDTITMDFDSLRAVQSGLGTA
GLIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWKIMRKLVKGTATYDDIDLLLSISYQIEGHTICALGDAAA
WPVQGLIRHFRGVIEERIDNCIRKS

Sequences:

>Translated_425_residues
MLEDKDKVFTNLSGQGSPFLKAAKSRGIWSNILDILNLGSEHIIQEVKKSGLRGRGGAGFSTGLKWSFMPKTRKEGQPAY
LVVNADESEPGTCKDRDILRYEPHRLIEGILIAGFAMRVTTAYIYIRGEFYNEYLILSEALKEAYKAKLIGKNACKSGYD
IDIFIHRGAGAYICGEETAQLESLEGRKGMPRLKPPFPAAIGLYGCPTTINNVETIATIGEILRRGSNWFASLGKENNTG
TKIFCISGHVNNPCNVEEELGIPMRELIEKYAGGVRGGWDNLLAVIPGGSSVPVLPKSICDTITMDFDSLRAVQSGLGTA
GLIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWKIMRKLVKGTATYDDIDLLLSISYQIEGHTICALGDAAA
WPVQGLIRHFRGVIEERIDNCIRKS
>Mature_425_residues
MLEDKDKVFTNLSGQGSPFLKAAKSRGIWSNILDILNLGSEHIIQEVKKSGLRGRGGAGFSTGLKWSFMPKTRKEGQPAY
LVVNADESEPGTCKDRDILRYEPHRLIEGILIAGFAMRVTTAYIYIRGEFYNEYLILSEALKEAYKAKLIGKNACKSGYD
IDIFIHRGAGAYICGEETAQLESLEGRKGMPRLKPPFPAAIGLYGCPTTINNVETIATIGEILRRGSNWFASLGKENNTG
TKIFCISGHVNNPCNVEEELGIPMRELIEKYAGGVRGGWDNLLAVIPGGSSVPVLPKSICDTITMDFDSLRAVQSGLGTA
GLIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWMWKIMRKLVKGTATYDDIDLLLSISYQIEGHTICALGDAAA
WPVQGLIRHFRGVIEERIDNCIRKS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=417, Percent_Identity=65.7074340527578, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=65.5502392344498, Blast_Score=577, Evalue=1e-165,
Organism=Escherichia coli, GI1788620, Length=385, Percent_Identity=43.6363636363636, Blast_Score=321, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17531727, Length=417, Percent_Identity=64.5083932853717, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI19920794, Length=418, Percent_Identity=65.311004784689, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550452, Length=417, Percent_Identity=62.3501199040767, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24653819, Length=418, Percent_Identity=48.0861244019139, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24653817, Length=418, Percent_Identity=44.2583732057416, Blast_Score=358, Evalue=5e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46736; Mature: 46736

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDKDKVFTNLSGQGSPFLKAAKSRGIWSNILDILNLGSEHIIQEVKKSGLRGRGGAGF
CCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGLKWSFMPKTRKEGQPAYLVVNADESEPGTCKDRDILRYEPHRLIEGILIAGFAMRVT
CCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHEEE
TAYIYIRGEFYNEYLILSEALKEAYKAKLIGKNACKSGYDIDIFIHRGAGAYICGEETAQ
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCCEEEECCHHHH
LESLEGRKGMPRLKPPFPAAIGLYGCPTTINNVETIATIGEILRRGSNWFASLGKENNTG
HHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCC
TKIFCISGHVNNPCNVEEELGIPMRELIEKYAGGVRGGWDNLLAVIPGGSSVPVLPKSIC
CEEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHH
DTITMDFDSLRAVQSGLGTAGLIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWM
HHHHCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
WKIMRKLVKGTATYDDIDLLLSISYQIEGHTICALGDAAAWPVQGLIRHFRGVIEERIDN
HHHHHHHHHCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
CIRKS
HHCCC
>Mature Secondary Structure
MLEDKDKVFTNLSGQGSPFLKAAKSRGIWSNILDILNLGSEHIIQEVKKSGLRGRGGAGF
CCCCHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGLKWSFMPKTRKEGQPAYLVVNADESEPGTCKDRDILRYEPHRLIEGILIAGFAMRVT
CCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHEEE
TAYIYIRGEFYNEYLILSEALKEAYKAKLIGKNACKSGYDIDIFIHRGAGAYICGEETAQ
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCCEEEECCHHHH
LESLEGRKGMPRLKPPFPAAIGLYGCPTTINNVETIATIGEILRRGSNWFASLGKENNTG
HHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCC
TKIFCISGHVNNPCNVEEELGIPMRELIEKYAGGVRGGWDNLLAVIPGGSSVPVLPKSIC
CEEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHH
DTITMDFDSLRAVQSGLGTAGLIVMDKSTDIIAAIERLSHFYMHESCGQCTPCREGTGWM
HHHHCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
WKIMRKLVKGTATYDDIDLLLSISYQIEGHTICALGDAAAWPVQGLIRHFRGVIEERIDN
HHHHHHHHHCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
CIRKS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA