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The map label for this gene is nuoM [H]

Identifier: 58617216

GI number: 58617216

Start: 792208

End: 793668

Strand: Reverse

Name: nuoM [H]

Synonym: ERGA_CDS_04890

Alternate gene names: 58617216

Gene position: 793668-792208 (Counterclockwise)

Preceding gene: 58617217

Following gene: 58617215

Centisome position: 52.91

GC content: 27.1

Gene sequence:

>1461_bases
ATGCTGCTTTTTATGATTTTGTTGCCAATATTAGGGTCGTGCTTATTAACAATTAATAATTTTAAGACAACTTCAGTATT
GATAAAGGTAATTTCTCTAATATCTTCTGGGGCTACATTTATTCTCAACTTTATTATAGCTATAAAATTTGACTATTCAT
ATAAGGGATATCAATTTATATGTAACTTGTTACATGGTTTTTCAATAGGAGTAGATGGTTTATCATTACCTCTTATATTA
TTAACGAGTTTCTTGTTTTTATTATGTACTGTGTTTTCTCTTTTTAATATGAAGATATATAACTTACGTACGTTTATTGC
ATTATTATTATTATTAGAAGGATTAACGATCGGAGTATTTGCTTCACTTGATATTATAATGTTTTATATATTTTTTGAAT
CTGTTTTAATTCCTATGTTTTTTATTATAGGAATTTGGGGACATGAAGACAGGATATATGCTACATTTAAGTTATTTTTA
TATACTTTAGCTGGGTCTTTGTTATTCTTAATAGCTATTATATATATATATCTTTTTTCTGATAAGGTAAGTAATATAGA
ACAATTAAGTTACATTTTACCTAACTTTTTAAATATAAAAGCTCAGAAGTGGTTATGGTGTGCATTTTTTATCTCTTTTG
CAATAAAAATTCCTATTGTTCCTTTTCATACCTGGTTGCCTAATGCCCATGTTCAAGCACCAACTGTTGGATCTGTATTA
TTGGCTGGTATTTTGATCAAAGTAGGGACATATGCATTACTTAGATTTTCTATTCCCATGTTACCAGAAGCTAATATGTA
TTTTTCAAATTTTGTTATAATATTGAGTATTATTGGTGTTATTTATGCTTCATTAATTTCTTTTGTTCAGAGTAATATTA
AGAAATTTATTGCATATTCTTCAATTGCTCATATGGGATTTGTTACTGCAGGGATATTTTCTTTTAATGAATATGGAATA
TCAGGTGCTATATTTCAAATGATTAGTCATGGGTTGATATCTGCAGCATTATTTTTTTGTGTTGGTATGCTTTATGATAG
GAATCATACTTTAGAGATATCAAAATATAGTGGTTTAGCAAAAGTAATGCCAAAGTTTTCTATAATGTTTATATTTTTCA
CTATGGCCTCTATTGCTTTACCTGGTACTTCAGGGTTTGTAGGGGAATTCTTGTCTATATTAGGAGTTTTTCATTATTCT
AAATTATTTGCAGCTTTGATTGCTACTGGAGTTATATTAGGTGCTGTATATATGTTATTTTTATCTAAAGAAATAATCTG
GGGAGCATCTAATAGTAGTTTAATTGTATGTGACCTTAATAAGAATGAGTTATTTATTTTAATTATTTTAGCTACTCTTG
TACTAGTATTTGGAATATATCCTTATTATATTTTGTTAAAATCTTTGTCTCCATTTATGGAGCAATTGTCGTTAAGAAAC
TTATACTTTAGTAGTATTTGA

Upstream 100 bases:

>100_bases
ACAGACTGGTTTTATTTTCGATTATGCATTTGTAATGTTATTAGGATTGATAAGTATTGTCATGTGGTTAATTTATAATA
ATACAGGATTTTAAAACCTT

Downstream 100 bases:

>100_bases
GATTATTATGTATTGGAATAATTTTGTTTATATAATACCTGAAATTTTTTTAATCAGTTCATCTTTAATCCTTTTGTTAT
TGGGAATTGTTGTAGATAAA

Product: NADH-quinone oxidoreductase chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MLLFMILLPILGSCLLTINNFKTTSVLIKVISLISSGATFILNFIIAIKFDYSYKGYQFICNLLHGFSIGVDGLSLPLIL
LTSFLFLLCTVFSLFNMKIYNLRTFIALLLLLEGLTIGVFASLDIIMFYIFFESVLIPMFFIIGIWGHEDRIYATFKLFL
YTLAGSLLFLIAIIYIYLFSDKVSNIEQLSYILPNFLNIKAQKWLWCAFFISFAIKIPIVPFHTWLPNAHVQAPTVGSVL
LAGILIKVGTYALLRFSIPMLPEANMYFSNFVIILSIIGVIYASLISFVQSNIKKFIAYSSIAHMGFVTAGIFSFNEYGI
SGAIFQMISHGLISAALFFCVGMLYDRNHTLEISKYSGLAKVMPKFSIMFIFFTMASIALPGTSGFVGEFLSILGVFHYS
KLFAALIATGVILGAVYMLFLSKEIIWGASNSSLIVCDLNKNELFILIILATLVLVFGIYPYYILLKSLSPFMEQLSLRN
LYFSSI

Sequences:

>Translated_486_residues
MLLFMILLPILGSCLLTINNFKTTSVLIKVISLISSGATFILNFIIAIKFDYSYKGYQFICNLLHGFSIGVDGLSLPLIL
LTSFLFLLCTVFSLFNMKIYNLRTFIALLLLLEGLTIGVFASLDIIMFYIFFESVLIPMFFIIGIWGHEDRIYATFKLFL
YTLAGSLLFLIAIIYIYLFSDKVSNIEQLSYILPNFLNIKAQKWLWCAFFISFAIKIPIVPFHTWLPNAHVQAPTVGSVL
LAGILIKVGTYALLRFSIPMLPEANMYFSNFVIILSIIGVIYASLISFVQSNIKKFIAYSSIAHMGFVTAGIFSFNEYGI
SGAIFQMISHGLISAALFFCVGMLYDRNHTLEISKYSGLAKVMPKFSIMFIFFTMASIALPGTSGFVGEFLSILGVFHYS
KLFAALIATGVILGAVYMLFLSKEIIWGASNSSLIVCDLNKNELFILIILATLVLVFGIYPYYILLKSLSPFMEQLSLRN
LYFSSI
>Mature_486_residues
MLLFMILLPILGSCLLTINNFKTTSVLIKVISLISSGATFILNFIIAIKFDYSYKGYQFICNLLHGFSIGVDGLSLPLIL
LTSFLFLLCTVFSLFNMKIYNLRTFIALLLLLEGLTIGVFASLDIIMFYIFFESVLIPMFFIIGIWGHEDRIYATFKLFL
YTLAGSLLFLIAIIYIYLFSDKVSNIEQLSYILPNFLNIKAQKWLWCAFFISFAIKIPIVPFHTWLPNAHVQAPTVGSVL
LAGILIKVGTYALLRFSIPMLPEANMYFSNFVIILSIIGVIYASLISFVQSNIKKFIAYSSIAHMGFVTAGIFSFNEYGI
SGAIFQMISHGLISAALFFCVGMLYDRNHTLEISKYSGLAKVMPKFSIMFIFFTMASIALPGTSGFVGEFLSILGVFHYS
KLFAALIATGVILGAVYMLFLSKEIIWGASNSSLIVCDLNKNELFILIILATLVLVFGIYPYYILLKSLSPFMEQLSLRN
LYFSSI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=328, Percent_Identity=33.8414634146341, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI251831117, Length=271, Percent_Identity=26.1992619926199, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788613, Length=495, Percent_Identity=34.9494949494949, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1788827, Length=357, Percent_Identity=24.3697478991597, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788831, Length=282, Percent_Identity=25.531914893617, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788614, Length=430, Percent_Identity=22.3255813953488, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI2367154, Length=239, Percent_Identity=25.9414225941423, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54502; Mature: 54502

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLFMILLPILGSCLLTINNFKTTSVLIKVISLISSGATFILNFIIAIKFDYSYKGYQFI
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHHH
CNLLHGFSIGVDGLSLPLILLTSFLFLLCTVFSLFNMKIYNLRTFIALLLLLEGLTIGVF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ASLDIIMFYIFFESVLIPMFFIIGIWGHEDRIYATFKLFLYTLAGSLLFLIAIIYIYLFS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKVSNIEQLSYILPNFLNIKAQKWLWCAFFISFAIKIPIVPFHTWLPNAHVQAPTVGSVL
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCHHHHH
LAGILIKVGTYALLRFSIPMLPEANMYFSNFVIILSIIGVIYASLISFVQSNIKKFIAYS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIAHMGFVTAGIFSFNEYGISGAIFQMISHGLISAALFFCVGMLYDRNHTLEISKYSGLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCHH
KVMPKFSIMFIFFTMASIALPGTSGFVGEFLSILGVFHYSKLFAALIATGVILGAVYMLF
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKEIIWGASNSSLIVCDLNKNELFILIILATLVLVFGIYPYYILLKSLSPFMEQLSLRN
HHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFSSI
HHHHCC
>Mature Secondary Structure
MLLFMILLPILGSCLLTINNFKTTSVLIKVISLISSGATFILNFIIAIKFDYSYKGYQFI
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHHH
CNLLHGFSIGVDGLSLPLILLTSFLFLLCTVFSLFNMKIYNLRTFIALLLLLEGLTIGVF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ASLDIIMFYIFFESVLIPMFFIIGIWGHEDRIYATFKLFLYTLAGSLLFLIAIIYIYLFS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKVSNIEQLSYILPNFLNIKAQKWLWCAFFISFAIKIPIVPFHTWLPNAHVQAPTVGSVL
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCHHHHH
LAGILIKVGTYALLRFSIPMLPEANMYFSNFVIILSIIGVIYASLISFVQSNIKKFIAYS
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIAHMGFVTAGIFSFNEYGISGAIFQMISHGLISAALFFCVGMLYDRNHTLEISKYSGLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCHH
KVMPKFSIMFIFFTMASIALPGTSGFVGEFLSILGVFHYSKLFAALIATGVILGAVYMLF
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKEIIWGASNSSLIVCDLNKNELFILIILATLVLVFGIYPYYILLKSLSPFMEQLSLRN
HHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFSSI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA