| Definition | Ehrlichia ruminantium str. Gardel, complete genome. |
|---|---|
| Accession | NC_006831 |
| Length | 1,499,920 |
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The map label for this gene is dxr
Identifier: 58617214
GI number: 58617214
Start: 789562
End: 790725
Strand: Reverse
Name: dxr
Synonym: ERGA_CDS_04870
Alternate gene names: 58617214
Gene position: 790725-789562 (Counterclockwise)
Preceding gene: 58617215
Following gene: 58617213
Centisome position: 52.72
GC content: 30.33
Gene sequence:
>1164_bases GTGAAAACAGTTTCTATATTTGGTTCGACCGGAGCTATTGGTCAGATGATAATTGATGTGATACTTGCTAGTTCTGATAG TTATCAAGTAAAAGCATTGGTTGCAAAGTCAAACGTTCAATTACTAGCATTTCAAGCTAAGGTAGTTAATGCTGAAATGG TGGTTATTGCAGATGTTGGTTTATATAAAGAATTAAAGGATTTATTATTTGGTACTAATGTTAAAATTAGTGTTGGTGAT GTTGGGATGCAAATGGCAGCATCATTGAATGTGGATTATGTTATGATGGCTATTGTAGGAATAGCTGCACTTGTACCTAT GGTATATTTGATTAGTGCCGGTGTTAAAGTTATTGCCTTGGCAAACAAAGAAAGTGTTGTTTGTGGTGGAACATTATTAT TTAATTTAGCAAGAGAAAAAAATGTTAATATTATTCCTGTAGATTCAGAACATAATGCTATATTTCAAATACTTCATAGT AATGACAGAGAAAACATAGATAAGATTACTATTACTGGATCTGGTGGTGCATTATTATATATGGATCATGATCAAATGCG AAATATAACAGTTCAGGAAACAATAAAACATCCAGTTTGGAAAATGGGTAAAAAGATTTCCATTGATAGTGCAACTATGG TTAATAAATCTCTTGAAATTATAGAAGCTTATCATTTGTTTTCAGTAAAATCAGAAAAATTAGATGTAATTATACATCCT GAAGCGATAGTGCATGGTATAGTATCTTATGTAGATGGTGCTTGTATTGCTTTTATGTCTGTTCCTGATATGAAAATTTC AATTATGTACACATTGTCCTGGCCAAATAGAATGTCTATGTTGTATAAAAAGTTGAATTTGGCATCATACCATCAGTTAA CATTTATGAAACCTGATATTAACAAGTTTCCTGGAATAAGATTAGGTTTTGAAATTCTTAGAACATCAAATATTCATGCA AATAGTATTATTTTTAATACTGCTAATGAAGTTGCAGTTGATGCTTTTTTAAATAGAAAAATAGGATTTCTTGATATTGT GAATGTGATTTATAGTACATTAGATATGGTTGACTGTTTGCATATTAATTCCTTATCAGATATTCTGGAATGTGATTCTA TAGCAAGAAGGGTTGCATCTGATATCATTTGTAAATTGAATTAG
Upstream 100 bases:
>100_bases TGAAGCCAGTTATAGGTTATTTTTTACATTTTAATTTTTTTAATGGATAATAATGTGAATATTCGATATATAGTTTGTTG AAGTTTTTTATATTAGTTTT
Downstream 100 bases:
>100_bases TTATCTAATTTATATAAAACTTATATTGGTTTACACTACGATTGTTTTGAAAAATAGTATTTCATGTTTTGTATTTGCTG ATGTATATAGATTTTTAATA
Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Products: NA
Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase
Number of amino acids: Translated: 387; Mature: 387
Protein sequence:
>387_residues MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKVVNAEMVVIADVGLYKELKDLLFGTNVKISVGD VGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIALANKESVVCGGTLLFNLAREKNVNIIPVDSEHNAIFQILHS NDRENIDKITITGSGGALLYMDHDQMRNITVQETIKHPVWKMGKKISIDSATMVNKSLEIIEAYHLFSVKSEKLDVIIHP EAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDINKFPGIRLGFEILRTSNIHA NSIIFNTANEVAVDAFLNRKIGFLDIVNVIYSTLDMVDCLHINSLSDILECDSIARRVASDIICKLN
Sequences:
>Translated_387_residues MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKVVNAEMVVIADVGLYKELKDLLFGTNVKISVGD VGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIALANKESVVCGGTLLFNLAREKNVNIIPVDSEHNAIFQILHS NDRENIDKITITGSGGALLYMDHDQMRNITVQETIKHPVWKMGKKISIDSATMVNKSLEIIEAYHLFSVKSEKLDVIIHP EAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDINKFPGIRLGFEILRTSNIHA NSIIFNTANEVAVDAFLNRKIGFLDIVNVIYSTLDMVDCLHINSLSDILECDSIARRVASDIICKLN >Mature_387_residues MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKVVNAEMVVIADVGLYKELKDLLFGTNVKISVGD VGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIALANKESVVCGGTLLFNLAREKNVNIIPVDSEHNAIFQILHS NDRENIDKITITGSGGALLYMDHDQMRNITVQETIKHPVWKMGKKISIDSATMVNKSLEIIEAYHLFSVKSEKLDVIIHP EAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDINKFPGIRLGFEILRTSNIHA NSIIFNTANEVAVDAFLNRKIGFLDIVNVIYSTLDMVDCLHINSLSDILECDSIARRVASDIICKLN
Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
COG id: COG0743
COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DXR family
Homologues:
Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=37.593984962406, Blast_Score=257, Evalue=1e-69,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DXR_EHRRG (Q5FHA4)
Other databases:
- EMBL: CR925677 - RefSeq: YP_196413.1 - ProteinModelPortal: Q5FHA4 - SMR: Q5FHA4 - STRING: Q5FHA4 - GeneID: 3268420 - GenomeReviews: CR925677_GR - KEGG: erg:ERGA_CDS_04870 - eggNOG: COG0743 - HOGENOM: HBG430762 - OMA: IHSMVEY - ProtClustDB: PRK05447 - BioCyc: ERUM302409:ERGA_CDS_04870-MONOMER - HAMAP: MF_00183 - InterPro: IPR003821 - InterPro: IPR013644 - InterPro: IPR013512 - InterPro: IPR016040 - Gene3D: G3DSA:3.40.50.720 - PIRSF: PIRSF006205 - TIGRFAMs: TIGR00243
Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom
EC number: =1.1.1.267
Molecular weight: Translated: 42591; Mature: 42591
Theoretical pI: Translated: 6.85; Mature: 6.85
Prosite motif: NA
Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 4.9 %Met (Translated Protein) 6.2 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 4.9 %Met (Mature Protein) 6.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKVVNAEMVVIADVG CCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEEEEEECCEEEEEECCH LYKELKDLLFGTNVKISVGDVGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIAL HHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE ANKESVVCGGTLLFNLAREKNVNIIPVDSEHNAIFQILHSNDRENIDKITITGSGGALLY ECCCCEEECHHHEEEEHHCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCEEEE MDHDQMRNITVQETIKHPVWKMGKKISIDSATMVNKSLEIIEAYHLFSVKSEKLDVIIHP EEHHHHHCCCHHHHHCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHEECCCCEEEEECC EAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDI HHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCC NKFPGIRLGFEILRTSNIHANSIIFNTANEVAVDAFLNRKIGFLDIVNVIYSTLDMVDCL CCCCCCCCCHHHHCCCCCEECEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH HINSLSDILECDSIARRVASDIICKLN CCCCHHHHHHHHHHHHHHHHHHEEECC >Mature Secondary Structure MKTVSIFGSTGAIGQMIIDVILASSDSYQVKALVAKSNVQLLAFQAKVVNAEMVVIADVG CCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEEEEEECCEEEEEECCH LYKELKDLLFGTNVKISVGDVGMQMAASLNVDYVMMAIVGIAALVPMVYLISAGVKVIAL HHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE ANKESVVCGGTLLFNLAREKNVNIIPVDSEHNAIFQILHSNDRENIDKITITGSGGALLY ECCCCEEECHHHEEEEHHCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCEEEE MDHDQMRNITVQETIKHPVWKMGKKISIDSATMVNKSLEIIEAYHLFSVKSEKLDVIIHP EEHHHHHCCCHHHHHCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHEECCCCEEEEECC EAIVHGIVSYVDGACIAFMSVPDMKISIMYTLSWPNRMSMLYKKLNLASYHQLTFMKPDI HHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCC NKFPGIRLGFEILRTSNIHANSIIFNTANEVAVDAFLNRKIGFLDIVNVIYSTLDMVDCL CCCCCCCCCHHHHCCCCCEECEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH HINSLSDILECDSIARRVASDIICKLN CCCCHHHHHHHHHHHHHHHHHHEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA