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The map label for this gene is hemF [H]

Identifier: 58617194

GI number: 58617194

Start: 759374

End: 760240

Strand: Reverse

Name: hemF [H]

Synonym: ERGA_CDS_04670

Alternate gene names: 58617194

Gene position: 760240-759374 (Counterclockwise)

Preceding gene: 58617195

Following gene: 58617191

Centisome position: 50.69

GC content: 30.8

Gene sequence:

>867_bases
ATGAATGAATTGTCTATGAAAGATAAACAAAACATGGCTGTTAATTGGTTTAAGGAATTACAAAATAAACTTCTTTCTGC
ATTTTTATCAGTGGAAGAAAAATTTTCTTCTTCAGTACCAGAAGTTCAATATAAAGATTGGACAAGATCTGAAGGTGGAG
GAGGACATTCTATAATATTACAAGGTAATGTTTTTGAAAAGGCTGGTATAAATGTATCAGAAGTATATGGTAATATTACA
CAAAATTCTGAATTATTAAGTGTTATGAATTCTCATAAATTTAATACTTCTTATGTGGAAGGTACAGAATTTTGGGCAAG
TGGGATTTCTGTTGTTGCACATATGTGTTCTCCATTTGTTCCAGCTGTTCATATGAATACTAGATTTATTTCTGTATGTG
ACAAGAGTTGGTTTGGTGGTGGGATAGATTTAACTCCTACATATGAAAATAAAGAAGATGAAGAATTTTTTCATGCTAAT
TTGCGTACAATGTGTGATAGGCATAATCAGAAATATTATCCAAAATTCAAACAACAATGCGATGAATATTTTTTCCTGCA
TCATAGAAAAGAACCACGTGGTATTGGTGGAATATTTTATGATAATATCAACTCTGGAGATTGGGAATCTGATTTTTATT
ATACTAAGGAAGTTGGTAAATTTTTATTAGATATTTATCCAGTTATTGTCATGAGAAATATGTATAAAAGTTGGAGTCAA
GATGAGCGTGAGTATCAATTACTTAAGCGTGGTAGATATGTAGAGTTTAATCTGATTTATGACAGAGGTACAAGGTTTGG
TTTATTAACTAATGGAAATCCTGATGCAATTATGATGTCTATGCCTCCTGTGGTAAAATGGAAATGA

Upstream 100 bases:

>100_bases
TTTTTTTTATTTGTTGTTCTATTATATCTATTGTTTATAAAATAATTTCAAATTATATAAGCAATGAGTTTATATAACGG
TTTATAAGTCTGGTGTTATT

Downstream 100 bases:

>100_bases
ATTTGAATTATTGACTTAGTATTGATAAGTAATCATAACTTAGTTATTTCCTATTGAATTAACCGATATCAACTTCATTT
TATTCACATTGTTTAAAACA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNELSMKDKQNMAVNWFKELQNKLLSAFLSVEEKFSSSVPEVQYKDWTRSEGGGGHSIILQGNVFEKAGINVSEVYGNIT
QNSELLSVMNSHKFNTSYVEGTEFWASGISVVAHMCSPFVPAVHMNTRFISVCDKSWFGGGIDLTPTYENKEDEEFFHAN
LRTMCDRHNQKYYPKFKQQCDEYFFLHHRKEPRGIGGIFYDNINSGDWESDFYYTKEVGKFLLDIYPVIVMRNMYKSWSQ
DEREYQLLKRGRYVEFNLIYDRGTRFGLLTNGNPDAIMMSMPPVVKWK

Sequences:

>Translated_288_residues
MNELSMKDKQNMAVNWFKELQNKLLSAFLSVEEKFSSSVPEVQYKDWTRSEGGGGHSIILQGNVFEKAGINVSEVYGNIT
QNSELLSVMNSHKFNTSYVEGTEFWASGISVVAHMCSPFVPAVHMNTRFISVCDKSWFGGGIDLTPTYENKEDEEFFHAN
LRTMCDRHNQKYYPKFKQQCDEYFFLHHRKEPRGIGGIFYDNINSGDWESDFYYTKEVGKFLLDIYPVIVMRNMYKSWSQ
DEREYQLLKRGRYVEFNLIYDRGTRFGLLTNGNPDAIMMSMPPVVKWK
>Mature_288_residues
MNELSMKDKQNMAVNWFKELQNKLLSAFLSVEEKFSSSVPEVQYKDWTRSEGGGGHSIILQGNVFEKAGINVSEVYGNIT
QNSELLSVMNSHKFNTSYVEGTEFWASGISVVAHMCSPFVPAVHMNTRFISVCDKSWFGGGIDLTPTYENKEDEEFFHAN
LRTMCDRHNQKYYPKFKQQCDEYFFLHHRKEPRGIGGIFYDNINSGDWESDFYYTKEVGKFLLDIYPVIVMRNMYKSWSQ
DEREYQLLKRGRYVEFNLIYDRGTRFGLLTNGNPDAIMMSMPPVVKWK

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=291, Percent_Identity=41.2371134020619, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1788777, Length=290, Percent_Identity=40, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320249, Length=258, Percent_Identity=40.3100775193798, Blast_Score=202, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17864388, Length=290, Percent_Identity=40, Blast_Score=221, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33559; Mature: 33559

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELSMKDKQNMAVNWFKELQNKLLSAFLSVEEKFSSSVPEVQYKDWTRSEGGGGHSIIL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEE
QGNVFEKAGINVSEVYGNITQNSELLSVMNSHKFNTSYVEGTEFWASGISVVAHMCSPFV
ECCCHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCCCC
PAVHMNTRFISVCDKSWFGGGIDLTPTYENKEDEEFFHANLRTMCDRHNQKYYPKFKQQC
CEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DEYFFLHHRKEPRGIGGIFYDNINSGDWESDFYYTKEVGKFLLDIYPVIVMRNMYKSWSQ
HHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCC
DEREYQLLKRGRYVEFNLIYDRGTRFGLLTNGNPDAIMMSMPPVVKWK
HHHHHHHHHCCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MNELSMKDKQNMAVNWFKELQNKLLSAFLSVEEKFSSSVPEVQYKDWTRSEGGGGHSIIL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEE
QGNVFEKAGINVSEVYGNITQNSELLSVMNSHKFNTSYVEGTEFWASGISVVAHMCSPFV
ECCCHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCCCC
PAVHMNTRFISVCDKSWFGGGIDLTPTYENKEDEEFFHANLRTMCDRHNQKYYPKFKQQC
CEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DEYFFLHHRKEPRGIGGIFYDNINSGDWESDFYYTKEVGKFLLDIYPVIVMRNMYKSWSQ
HHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCC
DEREYQLLKRGRYVEFNLIYDRGTRFGLLTNGNPDAIMMSMPPVVKWK
HHHHHHHHHCCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA