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The map label for this gene is bioA [H]

Identifier: 58617122

GI number: 58617122

Start: 656328

End: 657605

Strand: Reverse

Name: bioA [H]

Synonym: ERGA_CDS_03950

Alternate gene names: 58617122

Gene position: 657605-656328 (Counterclockwise)

Preceding gene: 58617123

Following gene: 58617121

Centisome position: 43.84

GC content: 30.99

Gene sequence:

>1278_bases
ATGCATACTCACTCTTGCTTATGGTTTGATAAAGGCTATAAAAATATTTGGATGCCTTATACTCAAATGAAAAATACACC
TTTGCCATTGAAAGTTAAAGCTGCCAGTGGATGTTATATAATACTAGAAGATGATACTAAATTACTAGATGGTATATCTA
GTTGGTGGAGCGTATGTCATGGATACTCACACCCTCATATAGTAAAAAAAATACAAGATCAAGTTGCTCAACTATCTCAC
GTTATGTTTCCTGGATTAGCACATGAGCAAAGTTACACATTAGCATCACGTCTTGCAAATATATCTCCACAGAAAAAAAT
GGAAAGAGTATTTTTCTCAGATTCTGGATCAACTGCTGTTGAAGTAGCAATGAAGATGGCAGTACAATTTTATTCTAATA
TGGGTGATACTAATAAATGTCACTTTATTTCCTTTATTCATGGATATCACGGAGATACTATGGGATGTATGTCAGTATCT
GATCCAGAAAATATTCATGGAAATAAGTTTAAAAAATATCATCCTTCACAATTTAGAGTGCTCTTACCACAAAATAAAAA
AGAAATAGAAAATTTTCGAAGTATAGTCCATTCTATTAAGGATAGTACTGCTGCTATAATTTTAGAACCAATATTACAGG
CAGCAGGTGGAATGTTACTTCATCAACCAAGTATTGTAAAAGAAATCTATGATATAGCACATGATAATAACATATTATTT
ATTGCAGATGAAGTTGCTACAGGCTTTACTAGAACTGGCAGAATGTTTGCATGTGATGAAGTAGGGATAGTCCCAGATAT
TATGGTAATTGGCAAAGCTTTAACAGGTGGATTTTGTACTTTATCAGCAACTTTAGCTGTACCAGAAGTTTATAATGCAT
TTTTATCAGATAATATAAACGATGCTTTTATGCATGGTCCAACTTTTATGGGAAATCCATTGGCTTGTGCTGCAGCAAAT
GCTTCTCTTGATCTTTTCGATATGGAAGATGTAATACAAAAAGTTGCTATAATTGAAAATCAGTTAAACTCAGAATTAAA
TATATTTAAGCAACTAAATTATGTTGTTGATATAAGGGTAAAGGGTGCTACCGGAATAATAGAATTAGAAAATAATTTAA
TTAATAAAAACCATATTATTAAAAAAGGCATCGAATCAAATATATGGATACGCCCATTAGGAAATGTAATATATGTTATG
CCACCTTTTATCATAAATACTAATGAACTTTCCCAATTAGTAAAATCAATATATTTGATACTAAAACACAATATATAA

Upstream 100 bases:

>100_bases
CTTATCATTATATGATTAATATGAAATATCTTTTTTTTCTCTATAACTTACAATACAATACTTTATAATTAAACTTTTTA
TCAAAAAAAGTAACTATAAA

Downstream 100 bases:

>100_bases
TGACATTATTAATAATTAACTATACATAAACTTACAGCAGCATATGTAAGATTATTTAGCATGTTACTAAATAAGACATC
AGTTTTCGTATTATTCAATG

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MHTHSCLWFDKGYKNIWMPYTQMKNTPLPLKVKAASGCYIILEDDTKLLDGISSWWSVCHGYSHPHIVKKIQDQVAQLSH
VMFPGLAHEQSYTLASRLANISPQKKMERVFFSDSGSTAVEVAMKMAVQFYSNMGDTNKCHFISFIHGYHGDTMGCMSVS
DPENIHGNKFKKYHPSQFRVLLPQNKKEIENFRSIVHSIKDSTAAIILEPILQAAGGMLLHQPSIVKEIYDIAHDNNILF
IADEVATGFTRTGRMFACDEVGIVPDIMVIGKALTGGFCTLSATLAVPEVYNAFLSDNINDAFMHGPTFMGNPLACAAAN
ASLDLFDMEDVIQKVAIIENQLNSELNIFKQLNYVVDIRVKGATGIIELENNLINKNHIIKKGIESNIWIRPLGNVIYVM
PPFIINTNELSQLVKSIYLILKHNI

Sequences:

>Translated_425_residues
MHTHSCLWFDKGYKNIWMPYTQMKNTPLPLKVKAASGCYIILEDDTKLLDGISSWWSVCHGYSHPHIVKKIQDQVAQLSH
VMFPGLAHEQSYTLASRLANISPQKKMERVFFSDSGSTAVEVAMKMAVQFYSNMGDTNKCHFISFIHGYHGDTMGCMSVS
DPENIHGNKFKKYHPSQFRVLLPQNKKEIENFRSIVHSIKDSTAAIILEPILQAAGGMLLHQPSIVKEIYDIAHDNNILF
IADEVATGFTRTGRMFACDEVGIVPDIMVIGKALTGGFCTLSATLAVPEVYNAFLSDNINDAFMHGPTFMGNPLACAAAN
ASLDLFDMEDVIQKVAIIENQLNSELNIFKQLNYVVDIRVKGATGIIELENNLINKNHIIKKGIESNIWIRPLGNVIYVM
PPFIINTNELSQLVKSIYLILKHNI
>Mature_425_residues
MHTHSCLWFDKGYKNIWMPYTQMKNTPLPLKVKAASGCYIILEDDTKLLDGISSWWSVCHGYSHPHIVKKIQDQVAQLSH
VMFPGLAHEQSYTLASRLANISPQKKMERVFFSDSGSTAVEVAMKMAVQFYSNMGDTNKCHFISFIHGYHGDTMGCMSVS
DPENIHGNKFKKYHPSQFRVLLPQNKKEIENFRSIVHSIKDSTAAIILEPILQAAGGMLLHQPSIVKEIYDIAHDNNILF
IADEVATGFTRTGRMFACDEVGIVPDIMVIGKALTGGFCTLSATLAVPEVYNAFLSDNINDAFMHGPTFMGNPLACAAAN
ASLDLFDMEDVIQKVAIIENQLNSELNIFKQLNYVVDIRVKGATGIIELENNLINKNHIIKKGIESNIWIRPLGNVIYVM
PPFIINTNELSQLVKSIYLILKHNI

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=27.5779376498801, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=25.8215962441315, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI284507298, Length=310, Percent_Identity=28.3870967741935, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=25.5868544600939, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=25.6345177664975, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI13994255, Length=367, Percent_Identity=25.6130790190736, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=21.5962441314554, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=44.8687350835322, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=30.46875, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=26.7990074441687, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1789759, Length=357, Percent_Identity=27.1708683473389, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788044, Length=275, Percent_Identity=29.8181818181818, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787560, Length=384, Percent_Identity=27.34375, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=26.8608414239482, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=28.8135593220339, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=31.3588850174216, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=24.7685185185185, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=366, Percent_Identity=25.9562841530055, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17541228, Length=353, Percent_Identity=24.3626062322946, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=460, Percent_Identity=35.6521739130435, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=25.2983293556086, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=360, Percent_Identity=26.6666666666667, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357415, Length=410, Percent_Identity=26.8292682926829, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=27.122641509434, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=25.5868544600939, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=23.9080459770115, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281366494, Length=286, Percent_Identity=28.3216783216783, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667139, Length=286, Percent_Identity=28.3216783216783, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667143, Length=286, Percent_Identity=28.3216783216783, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47562; Mature: 47562

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTHSCLWFDKGYKNIWMPYTQMKNTPLPLKVKAASGCYIILEDDTKLLDGISSWWSVCH
CCCCCEEEEECCCCCEECCHHHCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHC
GYSHPHIVKKIQDQVAQLSHVMFPGLAHEQSYTLASRLANISPQKKMERVFFSDSGSTAV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHH
EVAMKMAVQFYSNMGDTNKCHFISFIHGYHGDTMGCMSVSDPENIHGNKFKKYHPSQFRV
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEE
LLPQNKKEIENFRSIVHSIKDSTAAIILEPILQAAGGMLLHQPSIVKEIYDIAHDNNILF
ECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHCCCCEEE
IADEVATGFTRTGRMFACDEVGIVPDIMVIGKALTGGFCTLSATLAVPEVYNAFLSDNIN
EEHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
DAFMHGPTFMGNPLACAAANASLDLFDMEDVIQKVAIIENQLNSELNIFKQLNYVVDIRV
HHHHCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHCCEEEEEEE
KGATGIIELENNLINKNHIIKKGIESNIWIRPLGNVIYVMPPFIINTNELSQLVKSIYLI
ECCCEEEEECCCCCCCCHHHHCCCCCCEEEEECCCEEEECCCEEECHHHHHHHHHHHHHH
LKHNI
HHCCC
>Mature Secondary Structure
MHTHSCLWFDKGYKNIWMPYTQMKNTPLPLKVKAASGCYIILEDDTKLLDGISSWWSVCH
CCCCCEEEEECCCCCEECCHHHCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHC
GYSHPHIVKKIQDQVAQLSHVMFPGLAHEQSYTLASRLANISPQKKMERVFFSDSGSTAV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHH
EVAMKMAVQFYSNMGDTNKCHFISFIHGYHGDTMGCMSVSDPENIHGNKFKKYHPSQFRV
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEE
LLPQNKKEIENFRSIVHSIKDSTAAIILEPILQAAGGMLLHQPSIVKEIYDIAHDNNILF
ECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHCCCCEEE
IADEVATGFTRTGRMFACDEVGIVPDIMVIGKALTGGFCTLSATLAVPEVYNAFLSDNIN
EEHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
DAFMHGPTFMGNPLACAAANASLDLFDMEDVIQKVAIIENQLNSELNIFKQLNYVVDIRV
HHHHCCCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHHCHHHHHHHHCCEEEEEEE
KGATGIIELENNLINKNHIIKKGIESNIWIRPLGNVIYVMPPFIINTNELSQLVKSIYLI
ECCCEEEEECCCCCCCCHHHHCCCCCCEEEEECCCEEEECCCEEECHHHHHHHHHHHHHH
LKHNI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]