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The map label for this gene is aprE [H]

Identifier: 58616878

GI number: 58616878

Start: 250074

End: 251618

Strand: Reverse

Name: aprE [H]

Synonym: ERGA_CDS_01510

Alternate gene names: 58616878

Gene position: 251618-250074 (Counterclockwise)

Preceding gene: 58616879

Following gene: 58616876

Centisome position: 16.78

GC content: 31.2

Gene sequence:

>1545_bases
ATGTTAAAACTACTTGATAATACATATATGTATAAGAAACTCAAAGAATTAGTAAAGACTGGGTTTTCTCTTCCAAAACT
TTTAGGTCATAATACACTCCACATAACAAACAATGAAGCACCAAGAAAATTACATGTTTTACAAAAAACACTACTCATAA
TAGACAGTATTATAAATTTCTTATTTAAATATAATAAAAAAGACACATCTAATGAAGTACTAAAAATATCATGGGGTCCA
CTATTTACTGGATTCATAGTAATTTTGTTATTTTTTGGTGTATTTGGAATATGGGCAGCAGTTGCTCCATTAGATGGATC
TGTAGTTGCACAAGGAGAAGTAATATCTTCATCAGAAAAACAAATAGTACAACACTTAGAAGGTGGTATTATAGAGAAAA
TCCTAGTTAAGGAAGGAGAATTTGTAGAAAAAAACCAACCCATAATATACCTACATAACACTACAGCCCAAGCTAATCTA
GATATTATAAAAGAACGTATGTTAGATATGCTAGCAACAGAAGCTAGGCTAACAGCTATAAAATATAACTACAACCACAT
AAAATTCCCAAATTCTATAAACAATTTATCTAATAAAGAAATACGGGATCAAATTATAAAGAACCAGCAACAACTCTTTG
AATCCCATCAGAAAAATATATCTGGTCAAATTAATATCTTACAACAACGTACTAAGCAATTACATCAAGAATTATCAGGA
TTATCTGCACAACTAACTTCAGCAACAACTCAACATCAATTGATTAATGAAGAATTAGCAGCAAAAAAAAGCTTACTAGC
AGATGGATATATTAGCAAACCTTACATTATTGCTCTTGAACGGCAGTATGCTGAATCTCAAGGGAAAATAGGACAAATAG
AGTCTGCTATTGCATCAGTAAATCAAAAAATCGGAGAAAATAAATTAGAAATAATTAATATAACTAATAACGTACAAAAT
AAGATCAGTATTGAACTCAAAGATACAATTTCTGCAATTGCAGATCTAAAAGAAAGAATGAAAACTGCCCAAGACGTATT
AGATCGTACCGTGATTAGGTCTCCTCAATCTGGTATTATTACAGGATTAAAGTATCATACAGAAGGAGGTGTAATACCAC
CAGGAGCACCTATTACAAACGTTGTACCATCAGATGACAATTTAATTGTAGATGCAAAAATACAAACAAGAAATATAGAA
GAAATACTGTCAGCACAAGCAAAAGAAGTAAATATGGTATCATATGAAAACTACAAAGGTTTAAAAGCAAAAGTACGTCT
TAGTGCTTATAACATACGTAAAGTTGGATTAGCAAATGGAATAGTTACGCAAGTATCAGCTGATGCACTAACTGAAGCAA
ACGGGATGCGTTATTATAAAATACAAGTAATAATTCCAAAGGAACAATCTAAGAAACTTAAAAACCTCAGACTATACCCC
GGAATGCCAGCAGAGGTTTTTATTATTACACAATCACGTACCCTACTTAACTACTTATTTACTCCTATCACAAGTACTTT
TGAAAAAGCCTTTAACGAAAGATAG

Upstream 100 bases:

>100_bases
AAATTGAATTTTATTAAAATTTTATATAAATTAATGTATTTAAAACATTTATTTAGCAAATTGTATCTTATAATTATTTG
CGAGATATGTTATAACCTAG

Downstream 100 bases:

>100_bases
ATGTAATCGTAGCAAAACAGTCGCCTGTATATACTTATCTATTAGCTCTTCACTATTGGGTAATATACTCTTATTTATCC
TTATTAGTACACCATAATAC

Product: alkaline protease secretion protein AprE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MLKLLDNTYMYKKLKELVKTGFSLPKLLGHNTLHITNNEAPRKLHVLQKTLLIIDSIINFLFKYNKKDTSNEVLKISWGP
LFTGFIVILLFFGVFGIWAAVAPLDGSVVAQGEVISSSEKQIVQHLEGGIIEKILVKEGEFVEKNQPIIYLHNTTAQANL
DIIKERMLDMLATEARLTAIKYNYNHIKFPNSINNLSNKEIRDQIIKNQQQLFESHQKNISGQINILQQRTKQLHQELSG
LSAQLTSATTQHQLINEELAAKKSLLADGYISKPYIIALERQYAESQGKIGQIESAIASVNQKIGENKLEIINITNNVQN
KISIELKDTISAIADLKERMKTAQDVLDRTVIRSPQSGIITGLKYHTEGGVIPPGAPITNVVPSDDNLIVDAKIQTRNIE
EILSAQAKEVNMVSYENYKGLKAKVRLSAYNIRKVGLANGIVTQVSADALTEANGMRYYKIQVIIPKEQSKKLKNLRLYP
GMPAEVFIITQSRTLLNYLFTPITSTFEKAFNER

Sequences:

>Translated_514_residues
MLKLLDNTYMYKKLKELVKTGFSLPKLLGHNTLHITNNEAPRKLHVLQKTLLIIDSIINFLFKYNKKDTSNEVLKISWGP
LFTGFIVILLFFGVFGIWAAVAPLDGSVVAQGEVISSSEKQIVQHLEGGIIEKILVKEGEFVEKNQPIIYLHNTTAQANL
DIIKERMLDMLATEARLTAIKYNYNHIKFPNSINNLSNKEIRDQIIKNQQQLFESHQKNISGQINILQQRTKQLHQELSG
LSAQLTSATTQHQLINEELAAKKSLLADGYISKPYIIALERQYAESQGKIGQIESAIASVNQKIGENKLEIINITNNVQN
KISIELKDTISAIADLKERMKTAQDVLDRTVIRSPQSGIITGLKYHTEGGVIPPGAPITNVVPSDDNLIVDAKIQTRNIE
EILSAQAKEVNMVSYENYKGLKAKVRLSAYNIRKVGLANGIVTQVSADALTEANGMRYYKIQVIIPKEQSKKLKNLRLYP
GMPAEVFIITQSRTLLNYLFTPITSTFEKAFNER
>Mature_514_residues
MLKLLDNTYMYKKLKELVKTGFSLPKLLGHNTLHITNNEAPRKLHVLQKTLLIIDSIINFLFKYNKKDTSNEVLKISWGP
LFTGFIVILLFFGVFGIWAAVAPLDGSVVAQGEVISSSEKQIVQHLEGGIIEKILVKEGEFVEKNQPIIYLHNTTAQANL
DIIKERMLDMLATEARLTAIKYNYNHIKFPNSINNLSNKEIRDQIIKNQQQLFESHQKNISGQINILQQRTKQLHQELSG
LSAQLTSATTQHQLINEELAAKKSLLADGYISKPYIIALERQYAESQGKIGQIESAIASVNQKIGENKLEIINITNNVQN
KISIELKDTISAIADLKERMKTAQDVLDRTVIRSPQSGIITGLKYHTEGGVIPPGAPITNVVPSDDNLIVDAKIQTRNIE
EILSAQAKEVNMVSYENYKGLKAKVRLSAYNIRKVGLANGIVTQVSADALTEANGMRYYKIQVIIPKEQSKKLKNLRLYP
GMPAEVFIITQSRTLLNYLFTPITSTFEKAFNER

Specific function: Involved in the secretion of alkaline protease [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 57749; Mature: 57749

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLLDNTYMYKKLKELVKTGFSLPKLLGHNTLHITNNEAPRKLHVLQKTLLIIDSIINF
CCEEHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LFKYNKKDTSNEVLKISWGPLFTGFIVILLFFGVFGIWAAVAPLDGSVVAQGEVISSSEK
HHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHCCHHH
QIVQHLEGGIIEKILVKEGEFVEKNQPIIYLHNTTAQANLDIIKERMLDMLATEARLTAI
HHHHHHCCCHHHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEE
KYNYNHIKFPNSINNLSNKEIRDQIIKNQQQLFESHQKNISGQINILQQRTKQLHQELSG
EECCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
LSAQLTSATTQHQLINEELAAKKSLLADGYISKPYIIALERQYAESQGKIGQIESAIASV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHH
NQKIGENKLEIINITNNVQNKISIELKDTISAIADLKERMKTAQDVLDRTVIRSPQSGII
HHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TGLKYHTEGGVIPPGAPITNVVPSDDNLIVDAKIQTRNIEEILSAQAKEVNMVSYENYKG
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHCCHHHHCEEEEECCCCC
LKAKVRLSAYNIRKVGLANGIVTQVSADALTEANGMRYYKIQVIIPKEQSKKLKNLRLYP
CEEEEEEEEECEEEHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHCEEECC
GMPAEVFIITQSRTLLNYLFTPITSTFEKAFNER
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKLLDNTYMYKKLKELVKTGFSLPKLLGHNTLHITNNEAPRKLHVLQKTLLIIDSIINF
CCEEHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LFKYNKKDTSNEVLKISWGPLFTGFIVILLFFGVFGIWAAVAPLDGSVVAQGEVISSSEK
HHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHCCHHH
QIVQHLEGGIIEKILVKEGEFVEKNQPIIYLHNTTAQANLDIIKERMLDMLATEARLTAI
HHHHHHCCCHHHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEE
KYNYNHIKFPNSINNLSNKEIRDQIIKNQQQLFESHQKNISGQINILQQRTKQLHQELSG
EECCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
LSAQLTSATTQHQLINEELAAKKSLLADGYISKPYIIALERQYAESQGKIGQIESAIASV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHH
NQKIGENKLEIINITNNVQNKISIELKDTISAIADLKERMKTAQDVLDRTVIRSPQSGII
HHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
TGLKYHTEGGVIPPGAPITNVVPSDDNLIVDAKIQTRNIEEILSAQAKEVNMVSYENYKG
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHCCHHHHCEEEEECCCCC
LKAKVRLSAYNIRKVGLANGIVTQVSADALTEANGMRYYKIQVIIPKEQSKKLKNLRLYP
CEEEEEEEEECEEEHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHCEEECC
GMPAEVFIITQSRTLLNYLFTPITSTFEKAFNER
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1427098; 10984043 [H]