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The map label for this gene is purE [H]

Identifier: 58616826

GI number: 58616826

Start: 166021

End: 166533

Strand: Reverse

Name: purE [H]

Synonym: ERGA_CDS_00990

Alternate gene names: 58616826

Gene position: 166533-166021 (Counterclockwise)

Preceding gene: 58616827

Following gene: 58616823

Centisome position: 11.1

GC content: 34.31

Gene sequence:

>513_bases
ATGTCGATTAACGAAGATATTGCCGATGTTGCAGTAATTATGGGAAGCCAATCAGACTTTCCAACAATGAATAATTCAAT
ATCAATACTGGAAGAATTAAATATCAGCTATAAAACAATGATCATATCTGCTCATAGGACACCAGAAAGACTCTATACAT
TTGCAAAATCAGCAGAAACAAATGGATTCAAAATAATTATCGCTGGAGCAGGAGGCGCAGCTCATCTACCAGGATTAGTA
GCGTCTTTAACATATCTTCCCGTAATAGGGGTTCCAATAAAAAGTAGCAATCTTAATGGAATAGATAGTTTACTATCAAT
AGTACAGATGCCAAAAGGAATACCTGTAGCAACAATGTCAATAGGATCTTCAGGAGGATATAATGCAGCAATAATGGCAG
CTTCTATTCTAGCTTTATCGAATAACATAATAAAAACAAACTTACAAATATGGAGAGATAACTTATCTGCTTCTGTAAAA
CTATTACCAGATACATCTTTGCAGACTTCATAA

Upstream 100 bases:

>100_bases
ATCCCTTATATAGCAGTTTTATACAAAGATGTACGCATAATGAACATCAAAAATATAAACCAATTAAAATCAATTATTCA
AGAAATCAGAGAGAAATACA

Downstream 100 bases:

>100_bases
GTTAATGGTTAGTATATTTACTAATAAAGTCACATAAAAGATAATAAAAAACATATAGGAAATTTACTATAGTTATATAT
ACTGCGTTTGTTTATTATGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSINEDIADVAVIMGSQSDFPTMNNSISILEELNISYKTMIISAHRTPERLYTFAKSAETNGFKIIIAGAGGAAHLPGLV
ASLTYLPVIGVPIKSSNLNGIDSLLSIVQMPKGIPVATMSIGSSGGYNAAIMAASILALSNNIIKTNLQIWRDNLSASVK
LLPDTSLQTS

Sequences:

>Translated_170_residues
MSINEDIADVAVIMGSQSDFPTMNNSISILEELNISYKTMIISAHRTPERLYTFAKSAETNGFKIIIAGAGGAAHLPGLV
ASLTYLPVIGVPIKSSNLNGIDSLLSIVQMPKGIPVATMSIGSSGGYNAAIMAASILALSNNIIKTNLQIWRDNLSASVK
LLPDTSLQTS
>Mature_169_residues
SINEDIADVAVIMGSQSDFPTMNNSISILEELNISYKTMIISAHRTPERLYTFAKSAETNGFKIIIAGAGGAAHLPGLVA
SLTYLPVIGVPIKSSNLNGIDSLLSIVQMPKGIPVATMSIGSSGGYNAAIMAASILALSNNIIKTNLQIWRDNLSASVKL
LPDTSLQTS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=164, Percent_Identity=51.219512195122, Blast_Score=154, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=142, Percent_Identity=50.7042253521127, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17878; Mature: 17747

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINEDIADVAVIMGSQSDFPTMNNSISILEELNISYKTMIISAHRTPERLYTFAKSAET
CCCCHHHHHHHEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCC
NGFKIIIAGAGGAAHLPGLVASLTYLPVIGVPIKSSNLNGIDSLLSIVQMPKGIPVATMS
CCEEEEEEECCCCHHHHHHHHHHHHHHEECCEECCCCCCCHHHHHHHHHCCCCCCEEEEE
IGSSGGYNAAIMAASILALSNNIIKTNLQIWRDNLSASVKLLPDTSLQTS
ECCCCCCCHHHHHHHHHHHCCCEEEHHHHEEECCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SINEDIADVAVIMGSQSDFPTMNNSISILEELNISYKTMIISAHRTPERLYTFAKSAET
CCCHHHHHHHEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCC
NGFKIIIAGAGGAAHLPGLVASLTYLPVIGVPIKSSNLNGIDSLLSIVQMPKGIPVATMS
CCEEEEEEECCCCHHHHHHHHHHHHHHEECCEECCCCCCCHHHHHHHHHCCCCCCEEEEE
IGSSGGYNAAIMAASILALSNNIIKTNLQIWRDNLSASVKLLPDTSLQTS
ECCCCCCCHHHHHHHHHHHCCCEEEHHHHEEECCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]