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The map label for this gene is pdhB [H]

Identifier: 58616818

GI number: 58616818

Start: 149881

End: 150879

Strand: Reverse

Name: pdhB [H]

Synonym: ERGA_CDS_00910

Alternate gene names: 58616818

Gene position: 150879-149881 (Counterclockwise)

Preceding gene: 58616819

Following gene: 58616817

Centisome position: 10.06

GC content: 37.04

Gene sequence:

>999_bases
ATGAAAAATCTAACCGTACGAGAAGCATTATGTGCAGCAATACGTGAAGAAATGGAACGTGACCATACAGTATTAATAAT
GGGAGAAGAAGTAGGCGAATATCAAGGAGCATATAAGGTAACTCAGGGGTTACTTGAACAATTTGGTCCTGATAGAGTTA
TAGATACACCTATAACTGAACATGGATTTGCAGGGATTGGAATAGGAGCTGCATTTTCTGGTTTAAGACCCATAGTTGAG
TTTATGACATTCAACTTCGCTATGCAAGCAATTGATCAGATTATTAACTCTGCAGCAAAAACTAGCTATATGTCTGGTGG
ACAACTTAGCTGTCCTATTGTATTTAGAGGCCCAAACGGAGCAGCAGCAAGAGTGGGTGCACAACATTCCCAATGCTATG
CATCATGGTATGCACACATCCCTGGATTGAAAGTAATTGCACCATATTTCGCAGCAGATTGTAAAGGGTTATTAAAAGCA
GCAATCAGAGATCCAAACCCCATTATATTTCTTGAAAATGAAATTACATATGGACATACACATGAAGTACCAGATGTAGT
ATTAACTAAAGATTATATATCAGAGATAGGTAAAGCAGCTATTGTTAAAGAAGGTACGGATATTACAATCACAGCATTTT
CTCTACAAGTAAAGTCTGCATTAGAAGCAGCTGAACTTCTTGAAAAAGAAGGTATAAATGCAGAAGTTATAGATTTAAGA
ACTTTACGCCCCCTTGACGTAGAGCAAATATTAAACTCCATAAAGAAGACAAATAGAATCATCAGTGTAGAAGAAGGATG
GCCATATTCTGGTATAGGATCCGAGATTGCTGCATTAACCATGGAGCATGCCTTTGATTACTTAGATGCTCCAATGATCA
GAATCACAGCAAAAGATATTCCTCTACCTTATGCAGCAAATCTTGAAAAACTAGCCTTACCACAAATTCAAGATATATTA
GAAGCAGCACGTACTTCATGTATTCGTAATTATAAGTAA

Upstream 100 bases:

>100_bases
TTAACAATACCTTAGTAATATTAAACATGATGCAAATCTATTTGCATGTATTTATATTTCTTACATATAATTAGCAAAAT
TAACCGTAAGGTACTTAAAT

Downstream 100 bases:

>100_bases
TGCTACAATACACTTGTAACATATGTAAATTTATCAGCCTTTCTTACCCATAGCTAAAGATATTTCATATGGATAATTTT
TCATCAAGCTGTAACACTAT

Product: pyruvate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKNLTVREALCAAIREEMERDHTVLIMGEEVGEYQGAYKVTQGLLEQFGPDRVIDTPITEHGFAGIGIGAAFSGLRPIVE
FMTFNFAMQAIDQIINSAAKTSYMSGGQLSCPIVFRGPNGAAARVGAQHSQCYASWYAHIPGLKVIAPYFAADCKGLLKA
AIRDPNPIIFLENEITYGHTHEVPDVVLTKDYISEIGKAAIVKEGTDITITAFSLQVKSALEAAELLEKEGINAEVIDLR
TLRPLDVEQILNSIKKTNRIISVEEGWPYSGIGSEIAALTMEHAFDYLDAPMIRITAKDIPLPYAANLEKLALPQIQDIL
EAARTSCIRNYK

Sequences:

>Translated_332_residues
MKNLTVREALCAAIREEMERDHTVLIMGEEVGEYQGAYKVTQGLLEQFGPDRVIDTPITEHGFAGIGIGAAFSGLRPIVE
FMTFNFAMQAIDQIINSAAKTSYMSGGQLSCPIVFRGPNGAAARVGAQHSQCYASWYAHIPGLKVIAPYFAADCKGLLKA
AIRDPNPIIFLENEITYGHTHEVPDVVLTKDYISEIGKAAIVKEGTDITITAFSLQVKSALEAAELLEKEGINAEVIDLR
TLRPLDVEQILNSIKKTNRIISVEEGWPYSGIGSEIAALTMEHAFDYLDAPMIRITAKDIPLPYAANLEKLALPQIQDIL
EAARTSCIRNYK
>Mature_332_residues
MKNLTVREALCAAIREEMERDHTVLIMGEEVGEYQGAYKVTQGLLEQFGPDRVIDTPITEHGFAGIGIGAAFSGLRPIVE
FMTFNFAMQAIDQIINSAAKTSYMSGGQLSCPIVFRGPNGAAARVGAQHSQCYASWYAHIPGLKVIAPYFAADCKGLLKA
AIRDPNPIIFLENEITYGHTHEVPDVVLTKDYISEIGKAAIVKEGTDITITAFSLQVKSALEAAELLEKEGINAEVIDLR
TLRPLDVEQILNSIKKTNRIISVEEGWPYSGIGSEIAALTMEHAFDYLDAPMIRITAKDIPLPYAANLEKLALPQIQDIL
EAARTSCIRNYK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=56, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=52.3076923076923, Blast_Score=358, Evalue=3e-99,
Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=35.2760736196319, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=35.2760736196319, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI205277463, Length=245, Percent_Identity=29.3877551020408, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4507521, Length=245, Percent_Identity=29.3877551020408, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=59.6923076923077, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17506935, Length=328, Percent_Identity=37.5, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17539652, Length=271, Percent_Identity=26.9372693726937, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=325, Percent_Identity=56.9230769230769, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI21358145, Length=322, Percent_Identity=58.0745341614907, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24650940, Length=322, Percent_Identity=58.0745341614907, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=36.1111111111111, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=36.1111111111111, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=62.6373626373626, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=62.6373626373626, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36371; Mature: 36371

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTVREALCAAIREEMERDHTVLIMGEEVGEYQGAYKVTQGLLEQFGPDRVIDTPITE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCCEECCCCCC
HGFAGIGIGAAFSGLRPIVEFMTFNFAMQAIDQIINSAAKTSYMSGGQLSCPIVFRGPNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEECCCC
AAARVGAQHSQCYASWYAHIPGLKVIAPYFAADCKGLLKAAIRDPNPIIFLENEITYGHT
CHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
HEVPDVVLTKDYISEIGKAAIVKEGTDITITAFSLQVKSALEAAELLEKEGINAEVIDLR
CCCCCCEECHHHHHHHCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEC
TLRPLDVEQILNSIKKTNRIISVEEGWPYSGIGSEIAALTMEHAFDYLDAPMIRITAKDI
CCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
PLPYAANLEKLALPQIQDILEAARTSCIRNYK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNLTVREALCAAIREEMERDHTVLIMGEEVGEYQGAYKVTQGLLEQFGPDRVIDTPITE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCCEECCCCCC
HGFAGIGIGAAFSGLRPIVEFMTFNFAMQAIDQIINSAAKTSYMSGGQLSCPIVFRGPNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEECCCC
AAARVGAQHSQCYASWYAHIPGLKVIAPYFAADCKGLLKAAIRDPNPIIFLENEITYGHT
CHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
HEVPDVVLTKDYISEIGKAAIVKEGTDITITAFSLQVKSALEAAELLEKEGINAEVIDLR
CCCCCCEECHHHHHHHCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEC
TLRPLDVEQILNSIKKTNRIISVEEGWPYSGIGSEIAALTMEHAFDYLDAPMIRITAKDI
CCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
PLPYAANLEKLALPQIQDILEAARTSCIRNYK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]