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The map label for this gene is kefB [H]

Identifier: 58616815

GI number: 58616815

Start: 145200

End: 146909

Strand: Reverse

Name: kefB [H]

Synonym: ERGA_CDS_00880

Alternate gene names: 58616815

Gene position: 146909-145200 (Counterclockwise)

Preceding gene: 58616816

Following gene: 58616814

Centisome position: 9.79

GC content: 33.27

Gene sequence:

>1710_bases
ATGCATGATTCTAAGTATTTATTGGATATAATTACACTTCTTTCAGCTGCTATATTAATAGTTGTTCTATTCTGGAAACT
AAATATCAGTCCTGTACTAGGGTACTTCGTTGCTGGAACTCTTATCGGTGCTCATGGCTTAAATTTAGTAGAATCATCTG
TAATAATACAGAACTTAGGTGAATTTGGAGTGGTTTTCCTGTTGTTCTTAATAGGAATTGAGTTGACATTTGAAAGATTG
ATCGCAATGCGACTGCATGTATTTGGTTTCGGTACACTACAAGTTATAGTTACAACACTAGCCATATGGTATATTGCAAA
CAAGTTTGGCATAGATTCCAAAGGATCTATAATAATCGGAGGAGCATTAGCATTATCCTCAACAGCTATTGTACTACAAG
TATTACAAGAAAAAGGCTGCCAATCAACACAAGTAGGAAGACTTTCAATTGCTATTCTGCTATTACAAGATCTTGCAGTA
GTCCCATTAATTGTACTACTTCCGTTACTAAGTGGAGAATCCCATCACAGTATTCCTATATCATTATTATACTCTTTTAT
AAAAGCAGCTGTTGCGTTGACTTTAATTTTTATTACAGGTAGGTTATTATTAAGGCCGCTTTTTAACACCATTGCAGCAA
TAAAAAGTAGTGAGATTTTTATAGCAACCACATTGTTAATTGTTTTAGGATCAGCATTTATTACAGAAAATTTTAACTTA
TCAATGGCACTTGGTGCATTTGTTTCAGGACTTCTTGTTGCAGAAACTGAATACAGGCATGACGTAGAACAAGTAGTACT
TCCATTTAAAAAGCTGTTATTAGGCCTATTTTTTATGACAGTAGGAATGTCAATTGACATTAAGTTTGTAGTAAATAAAT
TACCAATAATAGGTTTGATTTCTTTCTCTTTAATAACATTAAAATCACTCATCATTTTTATATTATGTAGGTTTTTCAAA
TTTCACGTAGCTGCAGCCATACAAGCAGGATTATTACTTTCACAAGGCGGTGAATTTGCTTTTATCTTATTTGGCCTTGC
AGCAGAAAAGAATGTATTACCAAGTGATTTAGCACAAACTCTAATGATGATCACAACTGTAACAATGGCTTTTACTCCAC
CATTAGCAGCACTTGGTGATTGGATAGCAAAATTAATCACAAAAAAGAAAATATCTCTCAATTCTCAAGAACTTACTTTA
GACACAAAAGACCTTGATCAACACGTGATAGTTGTAGGATTTGGAAGAGTAGGACGTATGGTTGCTAAAGTGCTAGTAGC
AGAACATGTAAATTATATTGCATCTGACATACAACCAAAAACAGTAAAAGATGGAAGAGATGCAGGTTTTCCAGTATACC
TTGGCGATTTAACAAAATTAGCAACTTTAGAGTCTATGGCAATATCACGAGCTAAAATGATAATCATAGCAATCAATAAT
GAGGTCACTATTAAAAAGATTATATCTTTAGTTGCTCAACGCTTCCCAAACATAATAATCATTGTCAGGTTACCTGATTT
AAATAATGCAGAAGTATATAAAGAACTTGGGGCACATTATTTAATTCATGAAACATATGAAGTTGGATTACAATTAGGTG
CAATAGCGTTAAGCAACACTGGGTTCAGCAATCATGCCATTTCTTTACTAAAAGACAGGTTTAGAACAGTAAATTACGCT
GCAGTAAAAAACAAAGAAGCAAATGAGTAA

Upstream 100 bases:

>100_bases
GATACAGGTATGGTACCTGAAAATCAAAAACCAAGTATTGGGTGCTCCATAAAATGGAAATCAAAAAATTACAGTTTTTC
TTCTTAATTATAGATCTATT

Downstream 100 bases:

>100_bases
ACTATTTTTTATAATTGTTATAAGTTGATTTAACATTAAAGAAAAGTATTGCTGTTTTGAATATTGATAACAATAAAATC
CTCTAATAAAACAAATGTAA

Product: glutathione-regulated potassium-efflux system protein kefB

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MHDSKYLLDIITLLSAAILIVVLFWKLNISPVLGYFVAGTLIGAHGLNLVESSVIIQNLGEFGVVFLLFLIGIELTFERL
IAMRLHVFGFGTLQVIVTTLAIWYIANKFGIDSKGSIIIGGALALSSTAIVLQVLQEKGCQSTQVGRLSIAILLLQDLAV
VPLIVLLPLLSGESHHSIPISLLYSFIKAAVALTLIFITGRLLLRPLFNTIAAIKSSEIFIATTLLIVLGSAFITENFNL
SMALGAFVSGLLVAETEYRHDVEQVVLPFKKLLLGLFFMTVGMSIDIKFVVNKLPIIGLISFSLITLKSLIIFILCRFFK
FHVAAAIQAGLLLSQGGEFAFILFGLAAEKNVLPSDLAQTLMMITTVTMAFTPPLAALGDWIAKLITKKKISLNSQELTL
DTKDLDQHVIVVGFGRVGRMVAKVLVAEHVNYIASDIQPKTVKDGRDAGFPVYLGDLTKLATLESMAISRAKMIIIAINN
EVTIKKIISLVAQRFPNIIIIVRLPDLNNAEVYKELGAHYLIHETYEVGLQLGAIALSNTGFSNHAISLLKDRFRTVNYA
AVKNKEANE

Sequences:

>Translated_569_residues
MHDSKYLLDIITLLSAAILIVVLFWKLNISPVLGYFVAGTLIGAHGLNLVESSVIIQNLGEFGVVFLLFLIGIELTFERL
IAMRLHVFGFGTLQVIVTTLAIWYIANKFGIDSKGSIIIGGALALSSTAIVLQVLQEKGCQSTQVGRLSIAILLLQDLAV
VPLIVLLPLLSGESHHSIPISLLYSFIKAAVALTLIFITGRLLLRPLFNTIAAIKSSEIFIATTLLIVLGSAFITENFNL
SMALGAFVSGLLVAETEYRHDVEQVVLPFKKLLLGLFFMTVGMSIDIKFVVNKLPIIGLISFSLITLKSLIIFILCRFFK
FHVAAAIQAGLLLSQGGEFAFILFGLAAEKNVLPSDLAQTLMMITTVTMAFTPPLAALGDWIAKLITKKKISLNSQELTL
DTKDLDQHVIVVGFGRVGRMVAKVLVAEHVNYIASDIQPKTVKDGRDAGFPVYLGDLTKLATLESMAISRAKMIIIAINN
EVTIKKIISLVAQRFPNIIIIVRLPDLNNAEVYKELGAHYLIHETYEVGLQLGAIALSNTGFSNHAISLLKDRFRTVNYA
AVKNKEANE
>Mature_569_residues
MHDSKYLLDIITLLSAAILIVVLFWKLNISPVLGYFVAGTLIGAHGLNLVESSVIIQNLGEFGVVFLLFLIGIELTFERL
IAMRLHVFGFGTLQVIVTTLAIWYIANKFGIDSKGSIIIGGALALSSTAIVLQVLQEKGCQSTQVGRLSIAILLLQDLAV
VPLIVLLPLLSGESHHSIPISLLYSFIKAAVALTLIFITGRLLLRPLFNTIAAIKSSEIFIATTLLIVLGSAFITENFNL
SMALGAFVSGLLVAETEYRHDVEQVVLPFKKLLLGLFFMTVGMSIDIKFVVNKLPIIGLISFSLITLKSLIIFILCRFFK
FHVAAAIQAGLLLSQGGEFAFILFGLAAEKNVLPSDLAQTLMMITTVTMAFTPPLAALGDWIAKLITKKKISLNSQELTL
DTKDLDQHVIVVGFGRVGRMVAKVLVAEHVNYIASDIQPKTVKDGRDAGFPVYLGDLTKLATLESMAISRAKMIIIAINN
EVTIKKIISLVAQRFPNIIIIVRLPDLNNAEVYKELGAHYLIHETYEVGLQLGAIALSNTGFSNHAISLLKDRFRTVNYA
AVKNKEANE

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=389, Percent_Identity=25.4498714652956, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1786232, Length=566, Percent_Identity=34.6289752650177, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1789749, Length=567, Percent_Identity=34.2151675485009, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1786685, Length=538, Percent_Identity=27.8810408921933, Blast_Score=172, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 62067; Mature: 62067

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDSKYLLDIITLLSAAILIVVLFWKLNISPVLGYFVAGTLIGAHGLNLVESSVIIQNLG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EFGVVFLLFLIGIELTFERLIAMRLHVFGFGTLQVIVTTLAIWYIANKFGIDSKGSIIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
GALALSSTAIVLQVLQEKGCQSTQVGRLSIAILLLQDLAVVPLIVLLPLLSGESHHSIPI
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SLLYSFIKAAVALTLIFITGRLLLRPLFNTIAAIKSSEIFIATTLLIVLGSAFITENFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCH
SMALGAFVSGLLVAETEYRHDVEQVVLPFKKLLLGLFFMTVGMSIDIKFVVNKLPIIGLI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHH
SFSLITLKSLIIFILCRFFKFHVAAAIQAGLLLSQGGEFAFILFGLAAEKNVLPSDLAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHHH
LMMITTVTMAFTPPLAALGDWIAKLITKKKISLNSQELTLDTKDLDQHVIVVGFGRVGRM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCHHHHH
VAKVLVAEHVNYIASDIQPKTVKDGRDAGFPVYLGDLTKLATLESMAISRAKMIIIAINN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCEEEEEEEECC
EVTIKKIISLVAQRFPNIIIIVRLPDLNNAEVYKELGAHYLIHETYEVGLQLGAIALSNT
CCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCEEEHHHHHHHHHHCEEEEECC
GFSNHAISLLKDRFRTVNYAAVKNKEANE
CCCHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure
MHDSKYLLDIITLLSAAILIVVLFWKLNISPVLGYFVAGTLIGAHGLNLVESSVIIQNLG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EFGVVFLLFLIGIELTFERLIAMRLHVFGFGTLQVIVTTLAIWYIANKFGIDSKGSIIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
GALALSSTAIVLQVLQEKGCQSTQVGRLSIAILLLQDLAVVPLIVLLPLLSGESHHSIPI
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SLLYSFIKAAVALTLIFITGRLLLRPLFNTIAAIKSSEIFIATTLLIVLGSAFITENFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCH
SMALGAFVSGLLVAETEYRHDVEQVVLPFKKLLLGLFFMTVGMSIDIKFVVNKLPIIGLI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCHHHHH
SFSLITLKSLIIFILCRFFKFHVAAAIQAGLLLSQGGEFAFILFGLAAEKNVLPSDLAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCHHHHHHH
LMMITTVTMAFTPPLAALGDWIAKLITKKKISLNSQELTLDTKDLDQHVIVVGFGRVGRM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCHHHHH
VAKVLVAEHVNYIASDIQPKTVKDGRDAGFPVYLGDLTKLATLESMAISRAKMIIIAINN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCEEEEEEEECC
EVTIKKIISLVAQRFPNIIIIVRLPDLNNAEVYKELGAHYLIHETYEVGLQLGAIALSNT
CCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCEEEHHHHHHHHHHCEEEEECC
GFSNHAISLLKDRFRTVNYAAVKNKEANE
CCCHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA