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The map label for this gene is pth [H]

Identifier: 58616811

GI number: 58616811

Start: 138795

End: 139442

Strand: Reverse

Name: pth [H]

Synonym: ERGA_CDS_00840

Alternate gene names: 58616811

Gene position: 139442-138795 (Counterclockwise)

Preceding gene: 58616812

Following gene: 58616810

Centisome position: 9.3

GC content: 28.4

Gene sequence:

>648_bases
GTGGAGGAGAATCTTCAGGTACCACAACATCAGAAGATTAATAGTTTTTTTATTATCAGTTTTTCCATGCTGCATTTATT
AGTAGGTTTAGGAAATCCTGGCAAAGAGTATGAGTTAACGCGTCATAATGTTGGGTTTATGATTATAGATGCAATAATGC
ATCATTTTCTTTTTCCTGATTTCAAAAAAAAACATAATGCATTAATATCAAGTGGTAGTATACAGTCTTACAAGGTTATT
CTTGCTAAACCTTATACATTTATGAATAATTCAGGCGCACCTATTTCAAGTATAGTAAAACTGTATAAAATTCCATTAGA
TAACATTATTGTATTTCATGATGAAACTGATATAGACTTTTGTACCATAAGAATAAAAAAAGGTGGAGGTAATGCTGGAC
ATAATGGATTAAAATCAATAGATACACTACTTGGAAGAGACTATTGGAGAATTAGATTTGGTATAGGACATCCAAGTAAT
GGTTATGACTTATCGTACCATGTTTTATCACAATTTAATAATCTTAATGCTGTAAATAACACTATATCAAACATTATAGA
ACATATTTCATTACTATTCGAAAATGACAAATCTATATTTAAAAATAAAGTCAAAGACCTAATAAAATATACAGATATCT
CTAGTTAA

Upstream 100 bases:

>100_bases
GTAAGTGATTTAAACCTTCCTTCTGAAGTAACTGTTGTAATGAAAGAACATAATCCAACATTAGTAACTATCTCTGGTAC
AAGTTCTGACCAAGATACTA

Downstream 100 bases:

>100_bases
TATACATTATCACCAGAAAGAAATATACCTTCTTGAGATTAAACTATCGTTATTAAAATATAGAATTCTATAACAACATA
TTATAATCACTACAAACAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MEENLQVPQHQKINSFFIISFSMLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPDFKKKHNALISSGSIQSYKVI
LAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDFCTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSN
GYDLSYHVLSQFNNLNAVNNTISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS

Sequences:

>Translated_215_residues
MEENLQVPQHQKINSFFIISFSMLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPDFKKKHNALISSGSIQSYKVI
LAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDFCTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSN
GYDLSYHVLSQFNNLNAVNNTISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS
>Mature_215_residues
MEENLQVPQHQKINSFFIISFSMLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPDFKKKHNALISSGSIQSYKVI
LAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDFCTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSN
GYDLSYHVLSQFNNLNAVNNTISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=152, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1787455, Length=140, Percent_Identity=39.2857142857143, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 24426; Mature: 24426

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENLQVPQHQKINSFFIISFSMLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPD
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCC
FKKKHNALISSGSIQSYKVILAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDF
HHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCEE
CTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSNGYDLSYHVLSQFNNLNAVNN
EEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHH
TISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEENLQVPQHQKINSFFIISFSMLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPD
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCCC
FKKKHNALISSGSIQSYKVILAKPYTFMNNSGAPISSIVKLYKIPLDNIIVFHDETDIDF
HHHHHHHHCCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCEE
CTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSNGYDLSYHVLSQFNNLNAVNN
EEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHH
TISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA