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The map label for this gene is ribB [H]

Identifier: 58616799

GI number: 58616799

Start: 120352

End: 120987

Strand: Reverse

Name: ribB [H]

Synonym: ERGA_CDS_00720

Alternate gene names: 58616799

Gene position: 120987-120352 (Counterclockwise)

Preceding gene: 58616800

Following gene: 58616798

Centisome position: 8.07

GC content: 32.08

Gene sequence:

>636_bases
ATGGGTATCATTGTATCAGAAAATCCAAGTTTTATATCTTCTATAGAAGATATAATTGAAGATGCTAAAGCAGGTAAAGT
ATTTGTTTTAATTGATGATGAGCAAAGGGAAAATGAAGGTGATTTAGTAGTTTTAGCAGAAAAAGTCACTACTGATGCAA
TCAATCTTATGGTCACACATGGAAGTGGTATTGTATGTTTATCTATTACAGAAGACTTAATGTATAAATTAGGCTTAGAA
CTGATACCAAGAAGAAATATTAACAATAATAGTGCATCTTTTGCTACTTCTATAGATGCACGTTATGGTATTACAACAGG
TGTCTCTGTGCATGATAGAGTTCGTACTATACTAACTGCTGTTAGTAAAAATGTTACTATGGATGATCTTGTAACACCAG
GTCATATTTTTCCCATCGTATCTAAAAAAGGTGGTGTTTTAGAAAGACTGGGACATACAGAAGCAAGTGTTGATATTGCA
AGGATTGCTGGATTAACACCTGCAGCTGTAGTATGTGAGTTAATGAATCCAGATGGTACAATGTCAAGATTATCTGACAT
TATAGAATTTTCCCAACGTTATGATATTAAAGTTACTACTATTGCTAAACTAGTTGAATATATAAATACACATTAA

Upstream 100 bases:

>100_bases
AAAGAAGGTGATGTTGTAGAGGTAAAAACTCCAAAAGGTGATTACAGAATATACAAAATTATCAAGATTGAGTTTATATA
AGAGAAAAGTAGAGGAGTGA

Downstream 100 bases:

>100_bases
ACTGTACAGGGGTTAAACTTGCTGTGGATATCATAATAGAAAATCGTAAAGTAAGATTTAATTATTTTATTATACAGGAA
TTTGATGCAGGAATTGTTTT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGIIVSENPSFISSIEDIIEDAKAGKVFVLIDDEQRENEGDLVVLAEKVTTDAINLMVTHGSGIVCLSITEDLMYKLGLE
LIPRRNINNNSASFATSIDARYGITTGVSVHDRVRTILTAVSKNVTMDDLVTPGHIFPIVSKKGGVLERLGHTEASVDIA
RIAGLTPAAVVCELMNPDGTMSRLSDIIEFSQRYDIKVTTIAKLVEYINTH

Sequences:

>Translated_211_residues
MGIIVSENPSFISSIEDIIEDAKAGKVFVLIDDEQRENEGDLVVLAEKVTTDAINLMVTHGSGIVCLSITEDLMYKLGLE
LIPRRNINNNSASFATSIDARYGITTGVSVHDRVRTILTAVSKNVTMDDLVTPGHIFPIVSKKGGVLERLGHTEASVDIA
RIAGLTPAAVVCELMNPDGTMSRLSDIIEFSQRYDIKVTTIAKLVEYINTH
>Mature_210_residues
GIIVSENPSFISSIEDIIEDAKAGKVFVLIDDEQRENEGDLVVLAEKVTTDAINLMVTHGSGIVCLSITEDLMYKLGLEL
IPRRNINNNSASFATSIDARYGITTGVSVHDRVRTILTAVSKNVTMDDLVTPGHIFPIVSKKGGVLERLGHTEASVDIAR
IAGLTPAAVVCELMNPDGTMSRLSDIIEFSQRYDIKVTTIAKLVEYINTH

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=197, Percent_Identity=42.6395939086294, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=37.1980676328502, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 22943; Mature: 22811

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIVSENPSFISSIEDIIEDAKAGKVFVLIDDEQRENEGDLVVLAEKVTTDAINLMVTH
CCEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEHHCCCEEEEEEEC
GSGIVCLSITEDLMYKLGLELIPRRNINNNSASFATSIDARYGITTGVSVHDRVRTILTA
CCCEEEEEEHHHHHHHHCHHEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
VSKNVTMDDLVTPGHIFPIVSKKGGVLERLGHTEASVDIARIAGLTPAAVVCELMNPDGT
HHCCCCHHHCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCH
MSRLSDIIEFSQRYDIKVTTIAKLVEYINTH
HHHHHHHHHHHHHCCEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
GIIVSENPSFISSIEDIIEDAKAGKVFVLIDDEQRENEGDLVVLAEKVTTDAINLMVTH
CEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEHHCCCEEEEEEEC
GSGIVCLSITEDLMYKLGLELIPRRNINNNSASFATSIDARYGITTGVSVHDRVRTILTA
CCCEEEEEEHHHHHHHHCHHEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
VSKNVTMDDLVTPGHIFPIVSKKGGVLERLGHTEASVDIARIAGLTPAAVVCELMNPDGT
HHCCCCHHHCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCH
MSRLSDIIEFSQRYDIKVTTIAKLVEYINTH
HHHHHHHHHHHHHCCEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]