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The map label for this gene is dfp [H]

Identifier: 58616757

GI number: 58616757

Start: 35319

End: 35870

Strand: Reverse

Name: dfp [H]

Synonym: ERGA_CDS_00300

Alternate gene names: 58616757

Gene position: 35870-35319 (Counterclockwise)

Preceding gene: 58616760

Following gene: 58616756

Centisome position: 2.39

GC content: 29.71

Gene sequence:

>552_bases
TTGATTATGAAAATACTACTCGTTATTTCAGGAAGCATAGCAGCATATAAATCTCTAGATCTAATTAGAAAATTACAGGA
AAATAAGCACACAGTTATTGGAGTAATCAGTAAATCAGGAGAAAAATTTATAACTCCATTATCAGTAGCATCATTATCTC
AAAATTATGCATATACGAATGCAGATTTCTTTAACATTCACAATAGTATGCACCACATCTCACTCACAAGAAATTCAGAT
ATAGTACTAGTAGCACCAGCAACATTAGACATTATCGCAAAAACAGCTTGTGGAATTGCTGATGAATTAGCTACAACTAT
ATTAATTGCTTCCAATATTCCTATAGTTATGGTACCTGCTATGAATCCCACTATGTGGAATTCAAAATCAAATCAACGTA
ATATCAACCTTTTAAAAGAAGATAATATTACAATAATAGAACCAACAGAAGGGTTTGCAGCATGCAATGAATATGGATAC
GGAAAAATGGCAGAAATTCAAAATATAGTTTCATTTATAGAAAATTTTAAAAAAATTAACACTAAAAATTAG

Upstream 100 bases:

>100_bases
AAATTTTGCATTAAATTCTATACTTATTAATATCTAAACATTACTATAAACATTAAACTTTAAATATGCAAAAATATATC
ACAACAAATATTTACTTAAC

Downstream 100 bases:

>100_bases
AAAATATAAATTTAATTCTAGACTATATTCTACTTATTTCCATATTCAAAATATCATAATTACTATTTGATATTTAGAGA
ATATATTGCCTAACACCCAA

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MIMKILLVISGSIAAYKSLDLIRKLQENKHTVIGVISKSGEKFITPLSVASLSQNYAYTNADFFNIHNSMHHISLTRNSD
IVLVAPATLDIIAKTACGIADELATTILIASNIPIVMVPAMNPTMWNSKSNQRNINLLKEDNITIIEPTEGFAACNEYGY
GKMAEIQNIVSFIENFKKINTKN

Sequences:

>Translated_183_residues
MIMKILLVISGSIAAYKSLDLIRKLQENKHTVIGVISKSGEKFITPLSVASLSQNYAYTNADFFNIHNSMHHISLTRNSD
IVLVAPATLDIIAKTACGIADELATTILIASNIPIVMVPAMNPTMWNSKSNQRNINLLKEDNITIIEPTEGFAACNEYGY
GKMAEIQNIVSFIENFKKINTKN
>Mature_183_residues
MIMKILLVISGSIAAYKSLDLIRKLQENKHTVIGVISKSGEKFITPLSVASLSQNYAYTNADFFNIHNSMHHISLTRNSD
IVLVAPATLDIIAKTACGIADELATTILIASNIPIVMVPAMNPTMWNSKSNQRNINLLKEDNITIIEPTEGFAACNEYGY
GKMAEIQNIVSFIENFKKINTKN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=178, Percent_Identity=29.7752808988764, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87082301, Length=181, Percent_Identity=35.3591160220994, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 20188; Mature: 20188

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMKILLVISGSIAAYKSLDLIRKLQENKHTVIGVISKSGEKFITPLSVASLSQNYAYTN
CCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCHHHHHHCCCCEECC
ADFFNIHNSMHHISLTRNSDIVLVAPATLDIIAKTACGIADELATTILIASNIPIVMVPA
CHHEEECCCEEEEEEECCCCEEEEECCHHHHHHHHHCCHHHHHHHEEEEECCCCEEEEEC
MNPTMWNSKSNQRNINLLKEDNITIIEPTEGFAACNEYGYGKMAEIQNIVSFIENFKKIN
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
TKN
CCC
>Mature Secondary Structure
MIMKILLVISGSIAAYKSLDLIRKLQENKHTVIGVISKSGEKFITPLSVASLSQNYAYTN
CCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCHHHHHHCCCCEECC
ADFFNIHNSMHHISLTRNSDIVLVAPATLDIIAKTACGIADELATTILIASNIPIVMVPA
CHHEEECCCEEEEEEECCCCEEEEECCHHHHHHHHHCCHHHHHHHEEEEECCCCEEEEEC
MNPTMWNSKSNQRNINLLKEDNITIIEPTEGFAACNEYGYGKMAEIQNIVSFIENFKKIN
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
TKN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA