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The map label for this gene is gatD [H]

Identifier: 57652510

GI number: 57652510

Start: 272268

End: 273311

Strand: Direct

Name: gatD [H]

Synonym: SACOL0235

Alternate gene names: 57652510

Gene position: 272268-273311 (Clockwise)

Preceding gene: 57652509

Following gene: 57652511

Centisome position: 9.69

GC content: 38.03

Gene sequence:

>1044_bases
GTGAAAGCATTGAAATTATATGGCGTGGAAGATTTACGGTATGAGGATAATGAAAAGCCAGTCATTGAAAGTGCGAATGA
CGTTATTATTAAAGTACGAGCGACTGGCATATGTGGTTCAGACACGTCACGATACAAAAAAATGGGGCCATACATTAAAG
GTATGCCATTTGGTCATGAATTTTCAGGTGTAGTAGATGCCATTGGAAGTGATGTTACGCATGTTAATGTGGGCGACAAA
GTGACAGGTTGCCCAGCAATACCTTGTTATCAATGCGAGTATTGTTTAAAAGGTGAATATGCACGATGTGAAAAGTTATT
CGTCATTGGCTCATATGAACCTGGATCGTTCGCGGAATATGTCAAATTGCCAGCGCAAAATGTTTTAAAGGTTCCAGACA
ATGTTGATTACATTGAAGCAGCAATGGTTGAGCCATCAGCCGTTGTTGCGCATGGGTTTTATAAATCGAATATACAACCT
GGTATGACTGTTGCAGTAATGGGGTGTGGCAGTATAGGTTTGTTAGCTATTCAATGGGCACGAATATTTGGTGCTGCACA
TATCATCGCTATAGATATAGATGCGCATAAACTAGATATTGCAACATCATTGGGCGCACATCAAACAATCAATTCAAAAG
AAGAAAATCTTGAGAAATTCATCGAAAATCATTACGCCAATCAAATCGATTTAGCTATAGAATCATCAGGTGCTAAAGTT
ACGATTGGTCAAATATTGACGCTACCTAAAAAAGGTGGCGAGGTGGTATTACTCGGAATACCATATGATGATATTGAGAT
TGATCGCGTTCATTTTGAAAAAATTCTGCGTAACGAGTTGACAGTATGTGGCTCTTGGAACTGTTTGTCCAGTAATTTTC
CGGGCAAAGAGTGGACGGCAACCTTACATTATATGAAGACGAAAGATATTAATGTAAAGCCTATTATTTCTCATTTTTTA
CCGTTAGAAAAAGGCCCGGAGACATTTGATAAATTAGTTAACAAGAAAGAACGATTTGATAAAGTCATGTTTACGATTTA
TTAG

Upstream 100 bases:

>100_bases
TACTCGTAAGTAATTCCATTGTCATTGCAGGTTATTTTGCGACAGGTATTTTTAAAAAGAAAAAAGTTGTGAATTAAATC
AAATTTGAGGTGATTTACAA

Downstream 100 bases:

>100_bases
TATGCACCTTTGAGGACGAAAACGCTGGTATAGTTATAGCTATGAAAGTGCGAATGCCGTCTGGTCTATAGATACTATCG
AAATAATTCATCTTCGAATA

Product: hexitol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY

Sequences:

>Translated_347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY
>Mature_347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=30.4843304843305, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI71565152, Length=355, Percent_Identity=25.0704225352113, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=27.9329608938547, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4501933, Length=351, Percent_Identity=27.0655270655271, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=351, Percent_Identity=26.4957264957265, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=24.5762711864407, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=24.5762711864407, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.8221574344023, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=26.8221574344023, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71565154, Length=216, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788407, Length=310, Percent_Identity=36.4516129032258, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=31.044776119403, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=31.0850439882698, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=27.4566473988439, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=27.7310924369748, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=27.5862068965517, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786825, Length=269, Percent_Identity=33.457249070632, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=25.6329113924051, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=25.8720930232558, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081918, Length=263, Percent_Identity=29.277566539924, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=271, Percent_Identity=36.90036900369, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=244, Percent_Identity=32.3770491803279, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=244, Percent_Identity=31.5573770491803, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=268, Percent_Identity=29.4776119402985, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=300, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=297, Percent_Identity=24.5791245791246, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=283, Percent_Identity=28.2685512367491, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=31.8713450292398, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=31.8713450292398, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=30.1242236024845, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=386, Percent_Identity=26.1658031088083, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=27.6967930029155, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=384, Percent_Identity=26.0416666666667, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=257, Percent_Identity=27.2373540856031, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=258, Percent_Identity=28.2945736434109, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=250, Percent_Identity=29.6, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=28.955223880597, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=29.8816568047337, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737895, Length=350, Percent_Identity=25.4285714285714, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550770, Length=307, Percent_Identity=23.1270358306189, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=307, Percent_Identity=23.1270358306189, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221457811, Length=307, Percent_Identity=23.1270358306189, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 38402; Mature: 38402

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHE
CCCEEEECCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCH
FSGVVDAIGSDVTHVNVGDKVTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEY
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCHHHH
VKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQPGMTVAVMGCGSIGLLAIQWA
HHCCCHHEEECCCCCCHHHHHHCCCCHHEEECEECCCCCCCCEEEEEECCCHHHHHHHHH
RIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
HHHCCEEEEEEEECCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEE
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTA
EEEEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEE
TLHYMKTKDINVKPIISHFLPLEKGPETFDKLVNKKERFDKVMFTIY
EEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHE
CCCEEEECCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCH
FSGVVDAIGSDVTHVNVGDKVTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEY
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCHHHH
VKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQPGMTVAVMGCGSIGLLAIQWA
HHCCCHHEEECCCCCCHHHHHHCCCCHHEEECEECCCCCCCCEEEEEECCCHHHHHHHHH
RIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
HHHCCEEEEEEEECCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEE
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTA
EEEEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEE
TLHYMKTKDINVKPIISHFLPLEKGPETFDKLVNKKERFDKVMFTIY
EEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]