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The map label for this gene is ldhD [H]

Identifier: 57652296

GI number: 57652296

Start: 2636232

End: 2637230

Strand: Reverse

Name: ldhD [H]

Synonym: SACOL2574

Alternate gene names: 57652296

Gene position: 2637230-2636232 (Counterclockwise)

Preceding gene: 57652297

Following gene: 57652292

Centisome position: 93.87

GC content: 36.44

Gene sequence:

>999_bases
ATGACAAAAATTAAAATCATGAGTGTACGTGATGAAGATATGCCTTATATCAAGGCGTGGGCAGAGAAACATCATGTTGA
GGTAGATATTACTAAAGAAGCATTAACTGATGACAATGTTGAAGGTGTCGCTGGTTATGATGGCTTATCGCTATCACAAC
AAATACCATTATCAGAGCATGTTTATAAACGATTAAATGAACTAGGTATTAAACAAATCGCACAACGTAGTGCTGGATTT
GATACATATGATTTGGAGTTAGCAAACAAGTATAACTTTATTGTGTCAAATGTGCCGTCATACTCTCCGAATTCAATTGC
GGAGTTTGCTGTGAACCAGGCTATTAATGTGGTTCGTCATTTTAATCAAATTCAAACGAAAGTGCGGGAGCATGATTTTA
GATGGGAACCTACTATTTTATCGAAATCCATTAAAGATTTAAAAGTAGCTGTTATTGGTACAGGTCGAATTGGCCGTGTA
GTAGCCGATATATTTGCCAATGGTTATCAAAGTGATGTGGTCGCATACGACCCGTTTCCTAATGCTAAAATTGCAACGTA
TGTCGATTACAAAGATACGATTGAGGAAGCGGTTGAAGGTGCTGATATCGTGACATTACATGTACCTGCAACGAAATATA
ATCATTATCTATTTAATGCTGAATTATTTAAACATTTTAAAAAGGGCGCAGTATTTGTCAATTGTGCGAGAGGTTCTTTA
GTAGATACTAAGGCGTTATTAGACGCATTAGACAATGGTGTGATTAAAGGTGCAGCACTTGATACGTATGAATTTGAACG
CAAACTTTTCCCAAGTGATCAAAGGGGCAAAACACTGAACGATCCATTGTTAGAATCGTTGATTGACAGGGAAGATGTCA
TATTAACACCACATATTGCGTTTTATACTGAAGCTGCAGTTAAAAATCTAATTGTCGATGCATTAGATGCAACATTAGAT
GTATTGCAGACTGGAGATACTAGGTTACGAGTAAATTAA

Upstream 100 bases:

>100_bases
ATTTCATTGGCGTTAGATGACCAGAAATTAGACGAAGCTGCAATAAGATTAACAGAACTAGCATATTTATATGAATAATA
AAGTTAAGGGTGATGTTAAA

Downstream 100 bases:

>100_bases
AAATCGAACTGATGAGATAATTTGGATTGTTGGGATTCTCATCAGTTCGATTTTTTAATTTGGTGTTGATGACGTTGAAT
ATTGCCTAATTAAACGACAT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTKIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEHVYKRLNELGIKQIAQRSAGF
DTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRHFNQIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRV
VADIFANGYQSDVVAYDPFPNAKIATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARGSL
VDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPHIAFYTEAAVKNLIVDALDATLD
VLQTGDTRLRVN

Sequences:

>Translated_332_residues
MTKIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEHVYKRLNELGIKQIAQRSAGF
DTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRHFNQIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRV
VADIFANGYQSDVVAYDPFPNAKIATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARGSL
VDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPHIAFYTEAAVKNLIVDALDATLD
VLQTGDTRLRVN
>Mature_331_residues
TKIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEHVYKRLNELGIKQIAQRSAGFD
TYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRHFNQIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRVV
ADIFANGYQSDVVAYDPFPNAKIATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARGSLV
DTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPHIAFYTEAAVKNLIVDALDATLDV
LQTGDTRLRVN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=246, Percent_Identity=31.7073170731707, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=31.7073170731707, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI23308577, Length=239, Percent_Identity=30.1255230125523, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=30.4878048780488, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=30.4878048780488, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=30.4878048780488, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI6912396, Length=269, Percent_Identity=28.996282527881, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787645, Length=329, Percent_Identity=29.483282674772, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789279, Length=337, Percent_Identity=26.4094955489614, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082289, Length=255, Percent_Identity=25.4901960784314, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=236, Percent_Identity=28.3898305084746, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=24.0816326530612, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=311, Percent_Identity=26.3665594855305, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=334, Percent_Identity=25.4491017964072, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=267, Percent_Identity=27.3408239700375, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=230, Percent_Identity=25.6521739130435, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=28.968253968254, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921140, Length=239, Percent_Identity=29.2887029288703, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585516, Length=271, Percent_Identity=23.9852398523985, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28574286, Length=247, Percent_Identity=25.9109311740891, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571528, Length=268, Percent_Identity=27.2388059701493, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 37224; Mature: 37092

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEH
CCEEEEEEECCCCCCHHHHHHHHCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
VYKRLNELGIKQIAQRSAGFDTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRH
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
FNQIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRVVADIFANGYQSDVVAYDPFP
HHHHHHHHHHCCCCCCCHHHHHCHHHEEEEEEECCHHHHHHHHHHHCCCCCCEEEECCCC
NAKIATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARGSL
CCEEEEEECHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHCCCEEEEECCCCC
VDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPHIA
HHHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEECCHHH
FYTEAAVKNLIVDALDATLDVLQTGDTRLRVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure 
TKIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEH
CEEEEEEECCCCCCHHHHHHHHCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
VYKRLNELGIKQIAQRSAGFDTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRH
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
FNQIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRVVADIFANGYQSDVVAYDPFP
HHHHHHHHHHCCCCCCCHHHHHCHHHEEEEEEECCHHHHHHHHHHHCCCCCCEEEECCCC
NAKIATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARGSL
CCEEEEEECHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHCCCEEEEECCCCC
VDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPHIA
HHHHHHHHHHHCCCEECCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEECCHHH
FYTEAAVKNLIVDALDATLDVLQTGDTRLRVN
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA