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The map label for this gene is cycA [H]

Identifier: 57652253

GI number: 57652253

Start: 2498615

End: 2500024

Strand: Direct

Name: cycA [H]

Synonym: SACOL2441

Alternate gene names: 57652253

Gene position: 2498615-2500024 (Clockwise)

Preceding gene: 57652251

Following gene: 57652254

Centisome position: 88.94

GC content: 34.96

Gene sequence:

>1410_bases
ATGGCAAGAAAATTGCATAGAGAGTTGAATAACAGACACATCCAATTAATAGCAATTGGGGGCGCAATTGGAACTGGGTT
ATTCCTAGGATCAGGTCAAACAATATCTTTAACTGGTCCATCACTGTTATTCACATACATGATTATTGGGGTTGTACTAT
TCGCTTTTATGCGCGCATTAGGCGAATTGTTGTTGAGCAATACAAGATTTAATTCATTTGTTGATATTGCAAATGAATAT
TTAGGCCCTTTTGGTGGCTTTGTCATTGGCTGGACTTACTGGTTATGTTGGATTGTATCAAGTATGTCAGACCTAACTGC
GATGGGACAATACTTTGCATTTTGGTATCCACAAGTCCCAAATTGGATTACCGTGCTATTTATTGTTTTAATCTTGATTA
GCTTCAACTTATTAGGTGCCAGATTATTTGGTGAACTGGAGTTTTGGTTCTCGATTATTAAAGTTGTCACAATTATTGCG
ATGGTTATCGTTGGTCTTGTATTAATCTTTTTCTCATTTAAAACACATTATGGACATGCATCATTCACAAACTTAATCAG
TCACGGTGGCATGTTCCCTGGTGGAACATTTGGTTTCTTAATGTCATTCCAAATTGCTGTATATTCATTCATTGGTATTG
AACTTATAGGTGTAACTGCTGGTGAAACGAAAGATCCTGAAAAAACCTTACCGAAAGCAATTAATAATGTACCTATCCGT
ATTTTATTATTCTATATCGGTGGTCTATTAGTAATTATGTCAGTCATACCTTGGAATGATATCGATCCAAATAGTAGCCC
TTTCGTTAAACTCTTTACATTAATCGGCGTACCATTTGCAGCAGGTGTCGTTAACTTTGTCGTGCTAACTGCCGCGGCCT
CTGCTACAAATAGTGGTATCTATTCGAATAGTCGTATCTTATTCGGACTGTCACAACAAGGGTTAGGTCCTAAAGTTTTA
AATAAAACGAATAGTCATGGCGTGCCTTATTTATCAATGTTAGTTTCATCAATTGCATTACTTATAGCAGCCTTGTTAAA
CTACATTTTCCCTAATGCAATTCAACTATTCATATACGTTACAACGTTATCAACTGTGTTGTTTTTAGTTGTTTGGGCAA
TGATTATTGTCGCTTATCTAATGTATTTGAAAAAGCATCCTGAGGCACATAAAAACAGTAAATTTAAGTTGATTGGTGGT
AAGCCTATTGCTTACATTATTCTAGCGTTCTTCTTCTTTGTATTCATTTTATTATTCTTTAGTGACGAAACAAGAGCAGC
TATTTATATTTCGCCATTCTGGTTTATATTTTTATTTTTCTTTTATAAAAAATACAAAACGAATGCTGAAAAGCTCGCGT
ATGAACAACGACAAAATGACAGCGGTCATTTCAGATATGACAATCAATAA

Upstream 100 bases:

>100_bases
AAAAAATAATTGCTTTATTAAATGGATTTCTTTAGTATTTATAATTAAGAAAACGCTTACACACAACTTTTTTATTTGCT
TTATCCTGAGGAGGAAAATT

Downstream 100 bases:

>100_bases
TTTAAACATCTCGCTCTAGTATCAGTTCAACCGATACTAGAGTTTTTTTGAAAATAACTTCATTTTATCAATATATCTAT
GTCATTATGCCTTAAAAGTG

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEY
LGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIA
MVIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVL
NKTNSHGVPYLSMLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGG
KPIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ

Sequences:

>Translated_469_residues
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEY
LGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIA
MVIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVL
NKTNSHGVPYLSMLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGG
KPIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ
>Mature_468_residues
ARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEYL
GPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIAM
VIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIRI
LLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVLN
KTNSHGVPYLSMLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGK
PIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=335, Percent_Identity=24.1791044776119, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=50.4405286343612, Blast_Score=490, Evalue=1e-140,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=41.3186813186813, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=42.7312775330396, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=42.247191011236, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=39.689578713969, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI87081915, Length=397, Percent_Identity=37.7833753148615, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI87081708, Length=390, Percent_Identity=35.8974358974359, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788480, Length=485, Percent_Identity=35.0515463917526, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789017, Length=420, Percent_Identity=29.5238095238095, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI2367353, Length=316, Percent_Identity=23.1012658227848, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=430, Percent_Identity=23.0232558139535, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=471, Percent_Identity=31.6348195329087, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=31.8181818181818, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=410, Percent_Identity=30.7317073170732, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322892, Length=357, Percent_Identity=35.0140056022409, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=445, Percent_Identity=29.8876404494382, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=355, Percent_Identity=34.0845070422535, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=395, Percent_Identity=30.126582278481, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=28.6069651741293, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=391, Percent_Identity=30.1790281329923, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=27.1393643031785, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=406, Percent_Identity=26.1083743842365, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=29.2079207920792, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=25.31328320802, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=27.363184079602, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=23.8213399503722, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=23.6453201970443, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=417, Percent_Identity=27.3381294964029, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=466, Percent_Identity=24.8927038626609, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161077963, Length=425, Percent_Identity=21.8823529411765, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24667468, Length=432, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=411, Percent_Identity=21.4111922141119, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221512776, Length=411, Percent_Identity=21.4111922141119, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52559; Mature: 52428

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRAL
CCHHHHHHHCCCEEEEEEECCHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GELLLSNTRFNSFVDIANEYLGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVP
HHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIAMVIVGLVLIFFSFKTHYGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHCCCHHH
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
YSNSRILFGLSQQGLGPKVLNKTNSHGVPYLSMLVSSIALLIAALLNYIFPNAIQLFIYV
CCCCEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGKPIAYIILAFFFFVFILLFF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
SDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ
CCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCC
>Mature Secondary Structure 
ARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRAL
CHHHHHHHCCCEEEEEEECCHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHH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CCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]