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The map label for this gene is vraR [H]

Identifier: 57652103

GI number: 57652103

Start: 2004941

End: 2005570

Strand: Reverse

Name: vraR [H]

Synonym: SACOL1942

Alternate gene names: 57652103

Gene position: 2005570-2004941 (Counterclockwise)

Preceding gene: 57652104

Following gene: 57652099

Centisome position: 71.39

GC content: 33.81

Gene sequence:

>630_bases
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Upstream 100 bases:

>100_bases
GAAAGAGCTTTGGAAATTGGTGCAACGTTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACC
TTTAAATAAGGAGGATTCGT

Downstream 100 bases:

>100_bases
TTCATATCGAATTAAGAAAAGTTACTTACGCCAATCACAATATAACATCAAATAGACACCAAAAAACAGAGGTTTTCGCA
ATAATCATTAGCGAAAACCT

Product: DNA-binding response regulator VraR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Sequences:

>Translated_209_residues
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>Mature_208_residues
TIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLM
LTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAK
GYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=35.609756097561, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=30.4761904761905, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=33.9712918660287, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790102, Length=192, Percent_Identity=29.6875, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788712, Length=193, Percent_Identity=23.8341968911917, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=25.1231527093596, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=33.6538461538462, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789937, Length=171, Percent_Identity=28.0701754385965, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23546; Mature: 23414

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDD
CEEEEEEECCCHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHCCCHHHHHHHHHHC
MDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCHHHHHHHHHHHC
RGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHH
THVSNILSKLEVQDRTQAVIYAFQHNLIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDD
EEEEEEECCCHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHCCCHHHHHHHHHHC
MDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCHHHHHHHHHHHC
RGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHH
THVSNILSKLEVQDRTQAVIYAFQHNLIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]