BacMap

Definition	Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession	NC_002951
Length	2,809,422

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The map label for this gene is gmk

Identifier: 57651778

GI number: 57651778

Start: 1230617

End: 1231240

Strand: Direct

Name: gmk

Synonym: SACOL1221

Alternate gene names: 57651778

Gene position: 1230617-1231240 (Clockwise)

Preceding gene: 57651776

Following gene: 57651779

Centisome position: 43.8

GC content: 33.49

Gene sequence:

>624_bases
ATGGATAATGAAAAAGGATTGTTAATCGTTTTATCAGGACCATCTGGAGTAGGTAAAGGTACTGTTAGAAAACGAATATT
TGAAGATCCAAGTACATCATATAAGTATTCTATTTCAATGACAACACGTCAAATGCGTGAAGGTGAAGTTGATGGCGTAG
ATTACTTTTTTAAAACTAGGGATGCGTTTGAAGCTTTAATCAAAGATGACCAATTTATAGAATATGCTGAATATGTAGGC
AACTATTATGGTACACCAGTTCAATATGTTAAAGATACAATGGACGAAGGTCATGATGTATTTTTAGAAATTGAAGTAGA
AGGTGCAAAGCAAGTTAGAAAGAAATTTCCAGATGCGCTATTTATTTTCTTAGCACCTCCAAGTTTAGAACACTTGAGAG
AGCGATTAGTAGGTAGAGGAACAGAATCTGATGAGAAAATACAAAGTCGTATTAACGAAGCGCGTAAAGAAGTTGAAATG
ATGAATTTATACGATTACGTTGTAGTTAATGATGAAGTAGAACTTGCGAAGAATAGAATTCAATGTATTGTAGAAGCTGA
GCACTTAAAAAGAGAGCGCGTAGAAGCTAAGTATAGAAAAATGATTTTGGAGGCTAAAAAATAA

Upstream 100 bases:

>100_bases
AGAAATTATGGCATGCAATTTCAAATATGCTATACAATATAAAGAACAATGTGATATCATATTTAAATAATAGAAGATTA
GCTTAGAGAGGTCGTAAGGC

Downstream 100 bases:

>100_bases
TGTTAAATCCACCTTTAAACCAATTAACGTCACAAATTAAATCAAAGTATTTAATTGCAACAACTGCAGCGAAAAGAGCG
CGTGAAATTGATGAACAACC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK

Sequences:

>Translated_207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
>Mature_207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI38570142, Length=170, Percent_Identity=32.9411764705882, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI14780902, Length=206, Percent_Identity=27.1844660194175, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=30.0578034682081, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI21536464, Length=192, Percent_Identity=23.9583333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI119943108, Length=171, Percent_Identity=28.6549707602339, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI261862237, Length=171, Percent_Identity=28.6549707602339, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI119943106, Length=171, Percent_Identity=28.6549707602339, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI192447426, Length=179, Percent_Identity=27.3743016759777, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI21389483, Length=181, Percent_Identity=23.2044198895028, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4557529, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186700627, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186972120, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186700629, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI148539578, Length=186, Percent_Identity=30.6451612903226, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI148539628, Length=186, Percent_Identity=30.6451612903226, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=40.2010050251256, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=37.7906976744186, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=37.7906976744186, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=24.1573033707865, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17557440, Length=169, Percent_Identity=28.9940828402367, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=24.1573033707865, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556244, Length=142, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.1693989071038, Blast_Score=155, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=42.3841059602649, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161077626, Length=186, Percent_Identity=34.4086021505376, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640542, Length=186, Percent_Identity=34.4086021505376, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45554489, Length=186, Percent_Identity=34.4086021505376, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45554481, Length=186, Percent_Identity=34.4086021505376, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI85724806, Length=186, Percent_Identity=34.4086021505376, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI116007136, Length=186, Percent_Identity=34.4086021505376, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI221330164, Length=146, Percent_Identity=31.5068493150685, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330162, Length=146, Percent_Identity=31.5068493150685, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330166, Length=146, Percent_Identity=31.5068493150685, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI85816106, Length=126, Percent_Identity=32.5396825396825, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85816281, Length=126, Percent_Identity=32.5396825396825, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551002, Length=126, Percent_Identity=32.5396825396825, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281362230, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648808, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078487, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362232, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078485, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648810, Length=195, Percent_Identity=22.5641025641026, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360700, Length=175, Percent_Identity=30.2857142857143, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641282, Length=175, Percent_Identity=30.2857142857143, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554818, Length=175, Percent_Identity=30.2857142857143, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554804, Length=175, Percent_Identity=30.2857142857143, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641280, Length=175, Percent_Identity=30.2857142857143, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_STAA3 (Q2FHM9)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493799.1
- ProteinModelPortal:   Q2FHM9
- SMR:   Q2FHM9
- STRING:   Q2FHM9
- EnsemblBacteria:   EBSTAT00000036753
- GeneID:   3913657
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1102
- eggNOG:   COG0194
- GeneTree:   EBGT00050000024543
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24038; Mature: 24038

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTR
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHH
DAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDAL
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRI
EEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHH
QCIVEAEHLKRERVEAKYRKMILEAKK
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTR
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHH
DAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDAL
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRI
EEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHH
QCIVEAEHLKRERVEAKYRKMILEAKK
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA