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The map label for this gene is ctaB

Identifier: 57651725

GI number: 57651725

Start: 1137416

End: 1138327

Strand: Direct

Name: ctaB

Synonym: SACOL1125

Alternate gene names: 57651725

Gene position: 1137416-1138327 (Clockwise)

Preceding gene: 57651723

Following gene: 57651726

Centisome position: 40.49

GC content: 32.24

Gene sequence:

>912_bases
ATGAGCAAAGAGCATACTTTGTCACAAAATATTAGCAGAGTTAACTTCAAAGAATTGCAACAGATAATTAAAATGGGACT
TGTTCAAGGTAACTTAATTCCGGCTTTTGCGGGCGCATGGCTAGCAGTTGTAATGACAAATCATTCCTTCTTATCATCAA
TACCTCAAATTTTATTAATGCTATTTGGATCTACTTTAATTATGGGTGGCGCATGTGCGTTAAATAATTATTACGACCAA
GATATTGATCGTATTATGCCTAGTAAACAAAATAGACCAACTGTAAATAATAGAATTACAGATCAAAATTTATTACTATT
AAGTTTTGGTATGATGTTAGTTGGAGAAATTTGTTTGTTTTTATTGAATATACCATCAGGCGTACTTGGTCTTATGGGGA
TTGTAGGTTATGTGTCTTATTACTCAATATGGTCTAAAAGACATACAACATGGAACACAGTGATTGGGAGTTTTCCTGGA
GCAGTACCACCACTAATTGGATGGGTTGCAATTGAAGGACAAATTAGTTTAACAGCGATTGCGCTGTTTTTAGTTGTATT
TTGTTGGCAACCAATTCATTTTTATGCCTTAGCTATTAAACGTAAAGATGAATATGCACTTGCAAATATTCCAATGTTAC
CATCAGTTAAGGGCTTTAAACGTACACGTGTCAGTATGTTTATCTGGTTGATTATTTTATTGCCAGTACCTTTATTACTA
ATAAATTTAGGTGTCGTATTCGTAGTGTTAGCTACATTATTAAATTTAGGATGGATTGCATTAGGTTTAACAACATTTAA
GAAAAATTCAGATCAAACAAAATGGGCAACACAAATGTTTATATATTCACTAAATTATTTAGTGATCTTTTTCGTGTTAG
CTGTGATTGTTTCATTACTTACTTTGATCTAG

Upstream 100 bases:

>100_bases
CTTGTCGTTAATTTGTCACAATTTAATTTTATTAAACCTAGTCTTTTTATGCAATCTAAGATATCATAATCTTATATGAA
CAAATTTAAGGAGGGGGATT

Downstream 100 bases:

>100_bases
ATTAATTAAGTTAGGATGAAAAATATGGGCGTTCCAATTTTACCAACGATTAGTACGACATGTATTGTCATTAGTGCAAT
TTTAATTGCCATTGGTTGGA

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQ
DIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPG
AVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLL
INLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Sequences:

>Translated_303_residues
MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQ
DIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPG
AVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLL
INLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI
>Mature_302_residues
SKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQD
IDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGA
VPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLLI
NLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786631, Length=274, Percent_Identity=34.6715328467153, Blast_Score=147, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6325085, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921064, Length=233, Percent_Identity=25.7510729613734, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_STAA1 (A7X128)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441698.1
- STRING:   A7X128
- EnsemblBacteria:   EBSTAT00000002768
- GeneID:   5560897
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1108
- eggNOG:   COG0109
- GeneTree:   EBGT00050000024807
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- ProtClustDB:   PRK04375
- BioCyc:   SAUR418127:SAHV_1108-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33859; Mature: 33728

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc3e45f8)-; HASH(0xdd3185c)-; HASH(0xe19a748)-; HASH(0xdfb0af8)-; HASH(0xe4368e8)-; HASH(0xe436870)-; HASH(0xdbba320)-; HASH(0xe088648)-; HASH(0xdfffff4)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLM
CCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLF
HHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTAI
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHEECCCHHHHHH
ALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLL
HHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
INLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLI
HHH
>Mature Secondary Structure 
SKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLM
CCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH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HHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA