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The map label for this gene is czcD [H]

Identifier: 57651172

GI number: 57651172

Start: 173314

End: 174273

Strand: Direct

Name: czcD [H]

Synonym: SACOL0155

Alternate gene names: 57651172

Gene position: 173314-174273 (Clockwise)

Preceding gene: 57651171

Following gene: 57651174

Centisome position: 6.17

GC content: 31.98

Gene sequence:

>960_bases
ATGAATGGGAAAAAGGCGAATACGATAAACAGATACAAATATTTTCATCATGTCAATCATCAAAAAATTCAACAAAGTTC
TAAAAAGACGCTGTGGGCATCACTAATCATCACATTGTTATTTACAGTGATTGAATTTGTCGGAGGTTTAGTATCTAATT
CATTGGCATTACTGTCAGATTCATTTCATATGCTTAGTGATGTATTAGCACTTGGTTTATCTATGTTGGCCATTTATTTT
GCAAGTAAAAAGCCGACTGCACGATACACATTTGGATATTTAAGATTTGAGATATTAGCTGCATTTTTAAATGGTTTAGC
ATTAATTGTAATTTCAATCTGGATTTTATATGAAGCTATTGTACGTATTATTTATCCGCAACCAATTGAAAGTGGCATTA
TGTTTATGATTGCTAGTATTGGTTTACTCGTCAATATTATTTTGACTGTTATCCTTGTAAGGTCTTTAAAACAAGAAGAC
AATATCAATATTCAAAGTGCATTATGGCATTTCATGGGAGACTTATTGAACTCTATTGGTGTCATCGTTGCAGTTGTATT
GATTTACTTTACAGGATGGCGCATCATCGACCCAATCATTAGTATTGTAATTTCACTCATCATTTTACGTGGTGGTTATA
AAATTACGCGTAATGCGTGGTTAATTTTAATGGAAAGTGTGCCTCAACATTTGGATACTGATCAAATTATGGCAGATATT
AAAAACATAGATGGCATATTAGATGTACATGAATTTCATTTGTGGAGTATTACAACAGAGCATTATTCATTAAGTGCCCA
TGTTGTGTTAGATAAAAAATATGAGGGTGATGATTATCAAGCGATTGATCAAGTATCATCATTGTTGAAAGAAAAATATG
GCATTGCACATTCAACGTTGCAAATTGAAAACTTGCAATTGAATCCATTAGATGAGCCATACTTCGACAAATTAACATAA

Upstream 100 bases:

>100_bases
TAATTACGGAAGCATTAATATTAACCTGAGAAGCTATAAAGAATTATTTTTAAAAGCGACAATATTAAATACGACGCATT
TATTTAGGAGTGGCAAACGT

Downstream 100 bases:

>100_bases
ATAAAACATTGTAGCGCCTAAAACATTAATCTATGTCATAGGCGCACGTTTCGTTTTATACTTATGTTGCATCATTTAAA
TGATTTTCGTCAATTTCTTT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSDSFHMLSDVLALGLSMLAIYF
ASKKPTARYTFGYLRFEILAAFLNGLALIVISIWILYEAIVRIIYPQPIESGIMFMIASIGLLVNIILTVILVRSLKQED
NINIQSALWHFMGDLLNSIGVIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADI
KNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTLQIENLQLNPLDEPYFDKLT

Sequences:

>Translated_319_residues
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSDSFHMLSDVLALGLSMLAIYF
ASKKPTARYTFGYLRFEILAAFLNGLALIVISIWILYEAIVRIIYPQPIESGIMFMIASIGLLVNIILTVILVRSLKQED
NINIQSALWHFMGDLLNSIGVIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADI
KNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTLQIENLQLNPLDEPYFDKLT
>Mature_319_residues
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSDSFHMLSDVLALGLSMLAIYF
ASKKPTARYTFGYLRFEILAAFLNGLALIVISIWILYEAIVRIIYPQPIESGIMFMIASIGLLVNIILTVILVRSLKQED
NINIQSALWHFMGDLLNSIGVIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADI
KNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTLQIENLQLNPLDEPYFDKLT

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=306, Percent_Identity=30.0653594771242, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI21361112, Length=324, Percent_Identity=27.4691358024691, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI52352805, Length=309, Percent_Identity=30.0970873786408, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI289803013, Length=295, Percent_Identity=32.5423728813559, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI289803009, Length=295, Percent_Identity=32.5423728813559, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI289803007, Length=295, Percent_Identity=32.5423728813559, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI289803003, Length=295, Percent_Identity=32.5423728813559, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI64762489, Length=295, Percent_Identity=32.5423728813559, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI20070323, Length=338, Percent_Identity=26.9230769230769, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI14210520, Length=220, Percent_Identity=30, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI52351208, Length=116, Percent_Identity=39.6551724137931, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI52352803, Length=123, Percent_Identity=40.650406504065, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI222080086, Length=125, Percent_Identity=31.2, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=125, Percent_Identity=31.2, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21687224, Length=252, Percent_Identity=20.6349206349206, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI301898545, Length=252, Percent_Identity=20.6349206349206, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=281, Percent_Identity=38.7900355871886, Blast_Score=174, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=31.7610062893082, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI193210990, Length=340, Percent_Identity=29.7058823529412, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17555796, Length=311, Percent_Identity=31.1897106109325, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI32564488, Length=310, Percent_Identity=30.3225806451613, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17550440, Length=131, Percent_Identity=35.1145038167939, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17550442, Length=131, Percent_Identity=35.1145038167939, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=150, Percent_Identity=30.6666666666667, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=115, Percent_Identity=37.3913043478261, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=29.1428571428571, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325032, Length=254, Percent_Identity=28.3464566929134, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583858, Length=319, Percent_Identity=24.4514106583072, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=29.3768545994065, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=29.3768545994065, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=29.3768545994065, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=29.3768545994065, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=29.3768545994065, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24584409, Length=149, Percent_Identity=30.8724832214765, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI28574430, Length=149, Percent_Identity=30.8724832214765, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585900, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585898, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585896, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19921672, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24645863, Length=107, Percent_Identity=38.3177570093458, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36194; Mature: 36194

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSD
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
SFHMLSDVLALGLSMLAIYFASKKPTARYTFGYLRFEILAAFLNGLALIVISIWILYEAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRIIYPQPIESGIMFMIASIGLLVNIILTVILVRSLKQEDNINIQSALWHFMGDLLNSIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADI
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCHHHHHHHH
KNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTL
HHCCCHHHHHHHHEEEEEECCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHEE
QIENLQLNPLDEPYFDKLT
EEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSD
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
SFHMLSDVLALGLSMLAIYFASKKPTARYTFGYLRFEILAAFLNGLALIVISIWILYEAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRIIYPQPIESGIMFMIASIGLLVNIILTVILVRSLKQEDNINIQSALWHFMGDLLNSIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADI
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCHHHHHHHH
KNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTL
HHCCCHHHHHHHHEEEEEECCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHEE
QIENLQLNPLDEPYFDKLT
EEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA