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The map label for this gene is serS [H]

Identifier: 57651117

GI number: 57651117

Start: 12813

End: 14099

Strand: Direct

Name: serS [H]

Synonym: SACOL0009

Alternate gene names: 57651117

Gene position: 12813-14099 (Clockwise)

Preceding gene: 57651116

Following gene: 57651118

Centisome position: 0.46

GC content: 34.58

Gene sequence:

>1287_bases
ATGTTAGACATTAGATTATTCAGAAATGAGCCTGACACAGTTAAGAGCAAAATTGAATTACGTGGAGATGATCCAAAAGT
TGTAGATGAAATTTTAGAATTGGATGAGCAACGACGTAAATTAATTAGTGCAACAGAAGAAATGAAAGCACGTCGTAATA
AAGTAAGCGAAGAAATCGCATTAAAAAAACGTAATAAAGAAAATGCTGATGATGTGATTGCTGAAATGCGCACATTAGGT
GACGATATTAAAGAAAAAGATAGTCAATTAAATGAAATTGATAATAAAATGACAGGTATCCTTTGTCGTATTCCAAATTT
AATAAGTGATGATGTACCTCAAGGTGAATCTGATGAAGATAACGTTGAAGTTAAAAAGTGGGGTACACCACGTGAGTTTT
CATTTGAACCCAAAGCACATTGGGATATTGTAGAAGAATTGAAAATGGCTGATTTTGATCGTGCAGCAAAAGTTTCAGGT
GCGCGTTTTGTATATTTAACAAATGAAGGTGCGCAATTAGAGCGTGCTTTAATGAACTATATGATTACAAAACATACAAC
ACAACATGGTTATACAGAAATGATGGTACCACAGCTTGTGAACGCAGATACAATGTATGGTACAGGTCAATTACCTAAAT
TTGAAGAAGATTTATTTAAAGTAGAAAAAGAAGGATTATATACAATTCCAACTGCTGAAGTACCATTAACGAATTTCTAC
CGTAATGAAATTATTCAACCAGGTGTACTTCCTGAAAAATTCACTGGTCAATCTGCATGTTTCCGTAGTGAAGCAGGATC
AGCAGGTAGAGATACAAGAGGATTAATTCGTTTACATCAATTCGATAAAGTGGAAATGGTACGTTTTGAACAACCTGAAG
ATTCATGGAATGCTTTAGAAGAAATGACAACAAACGCAGAAGCAATTCTAGAAGAGTTAGGTTTACCATACCGTCGTGTT
ATTTTATGTACAGGTGATATTGGATTTAGTGCAAGCAAAACATATGATTTAGAAGTTTGGTTACCAAGCTACAATGATTA
TAAAGAAATTAGTTCATGCTCAAACTGTACGGATTTCCAAGCGCGTCGTGCTAACATCCGCTTCAAGCGTGACAAAGCAG
CTAAACCAGAATTAGCACATACATTAAATGGTAGTGGTTTAGCAGTTGGACGTACATTTGCTGCTATTGTTGAAAATTAC
CAAAATGAAGATGGAACAGTAACAATTCCAGAAGCATTAGTACCATTTATGGGTGGTAAAACACAAATTTCAAAACCAGT
TAAATAA

Upstream 100 bases:

>100_bases
ACGTCCCTTGTAGGGATGTGGTCTTTTTTTATTTTCTAAAAAATAAAGACGTACGTCATTCCATAATAAATGATAATTAT
TTGGGAAAGGATGAAGGTTA

Downstream 100 bases:

>100_bases
AGGCTTTAGCTACAAGCTTTAAAAAGTATATATCTACGTATACTTAAAGCAAGGGCAAGATACTTTAAATAATATTTTAA
AAAGTGGTGACGAAGCTGTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK

Sequences:

>Translated_428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK
>Mature_428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=465, Percent_Identity=33.9784946236559, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI8923421, Length=433, Percent_Identity=31.1778290993072, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI225579074, Length=444, Percent_Identity=31.3063063063063, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=52.3474178403756, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.618025751073, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17542084, Length=314, Percent_Identity=30.2547770700637, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=448, Percent_Identity=32.8125, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6321799, Length=422, Percent_Identity=31.7535545023697, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=30.6553911205074, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI17737985, Length=285, Percent_Identity=34.0350877192982, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48641; Mature: 48641

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIA
CCEEEEECCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDED
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNY
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHH
MITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHH
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALE
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHH
EMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQ
HHHCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCHHH
ARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGK
HHHCCCEEECCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHHCCCC
TQISKPVK
CCCCCCCC
>Mature Secondary Structure
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIA
CCEEEEECCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDED
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNY
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHH
MITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHH
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALE
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHH
EMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQ
HHHCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCHHH
ARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGK
HHHCCCEEECCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHHCCCC
TQISKPVK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA