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The map label for this gene is hisA [H]

Identifier: 57651066

GI number: 57651066

Start: 2771644

End: 2772348

Strand: Reverse

Name: hisA [H]

Synonym: SACOL2698

Alternate gene names: 57651066

Gene position: 2772348-2771644 (Counterclockwise)

Preceding gene: 57651067

Following gene: 57651065

Centisome position: 98.68

GC content: 39.01

Gene sequence:

>705_bases
ATGATTGAATTATGGCCAGCGATTGATTTGATTGGGTCAACAAGTGTGAGGTTAACAGAGGGTAAATATGATAGTGAAGA
AAAAATGTCACGCTCGGCTGAAGAAAGTATTGCTTACTATAGTCAATTTGAATGTGTGAATCGTATTCATATCGTCGACT
TGATAGGTGCTAAGGCACAGCATGCCCGAGAGTTTGATTATATTAAGTCATTGAGGAGATTAACAACCAAAGATATTGAA
GTAGGTGGTGGCATTCGTACGAAGTCACAAATCATGGACTACTTTGCCGCAGGGATTAATTATTGCATAGTTGGAACGAA
AGGTATTCAAGATACTGATTGGCTTAAAGAGATGGCACATACATTTCCAGGTCGCATTTATTTATCTGTTGATGCCTATG
GAGAAGATATTAAAGTGAACGGATGGGAAGAGGACACAGAGTTAAATTTATTTAGTTTTGTGAGACGGTTATCGGATATA
CCTCTTGGCGGCATTATATATACTGATATTGCTAAAGATGGCAAAATGTCCGGACCTAACTTTGAATTAACTGGTCAATT
AGTAAAGGCAACGACGATTCCTGTCATTGCTTCCGGTGGTATTAGACATCAGCAAGATATTCAACGATTAGCGTCGCTAA
ATGTTCACGCTGCTATTATAGGAAAGGCTGCACATCAAGCATCTTTTTGGGAGGGGCTAAAATGA

Upstream 100 bases:

>100_bases
GTTCAATTTAACAATTATATTGGTATTCAATTCCATCCTGAAAAAAGCGGTACATATGGGTTACAAATTTTGCGTCAGGC
AATACAAGGGGGATTTATAA

Downstream 100 bases:

>100_bases
TTAAAAAACGTATCATTCCATGTTTAGATGTCAAAGATGGTCGTGTCGTTAAAGGGATTCAATTTAAAGGATTAAGGGAT
ATTGGGAATCCTGTTGATTT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRRLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK

Sequences:

>Translated_234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRRLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
>Mature_234_residues
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIE
VGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRRLSDI
PLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=231, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26091; Mature: 26091

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQ
CCCCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCHHH
HAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAH
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
TFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRRLSDIPLGGIIYTDIAKDGKMSGPN
HCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
FELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
EEEEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQ
CCCCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCHHH
HAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAH
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
TFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVRRLSDIPLGGIIYTDIAKDGKMSGPN
HCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
FELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
EEEEEEEEEHEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA