Click here to switch to the map view.

The map label for this gene is hlgC

Identifier: 57650965

GI number: 57650965

Start: 2480061

End: 2481008

Strand: Direct

Name: hlgC

Synonym: SACOL2421

Alternate gene names: 57650965

Gene position: 2480061-2481008 (Clockwise)

Preceding gene: 57650964

Following gene: 57650966

Centisome position: 88.28

GC content: 32.81

Gene sequence:

>948_bases
ATGCTTAAAAATAAAATATTAACTACAACTTTATCTGTGAGCTTACTTGCCCCTCTTGCCAATCCGTTATTAGAAAATGC
TAAAGCTGCTAACGATACTGAAGACATCGGTAAAGGAAGCGATATAGAAATTATCAAAAGGACAGAAGATAAAACAAGTA
ATAAATGGGGCGTGACTCAAAATATTCAATTTGATTTTGTAAAGGATAAAAAATATAACAAAGATGCTTTGATATTAAAG
ATGCAAGGATTCATTAGCTCTAGAACAACATATTACAACTATAAAAAAACTAATCATGTTAAAGCTATGCGATGGCCATT
CCAATATAATATTGGTTTAAAAACAAATGATAAATATGTTTCTTTAATTAATTATTTACCTAAAAATAAAATTGAATCTA
CAAACGTGAGTCAGATATTAGGATACAATATCGGTGGTAATTTCCAATCAGCCCCATCACTCGGTGGTAATGGATCATTT
AACTATTCTAAATCGATTAGCTATACACAACAAAATTATGTAAGTGAAGTAGAACAACAAAACTCAAAAAGTGTTTTATG
GGGCGTCAAAGCGAATTCATTCGCCACTGAATCAGGTCAAAAATCAGCCTTTGATAGCGATTTATTTGTAGGCTACAAAC
CTCATAGTAAAGATCCTAGAGATTATTTCGTTCCAGACAGTGAGTTACCACCTCTTGTACAAAGTGGATTTAACCCTTCA
TTTATCGCCACAGTATCTCATGAAAAAGGTTCAAGCGATACAAGCGAATTTGAAATTACTTACGGAAGAAACATGGATGT
CACTCATGCCATTAAAAGATCAACGCATTATGGCAACAGTTATTTAGACGGACATAGAGTCCATAATGCATTTGTAAATA
GAAACTATACTGTGAAATACGAGGTCAATTGGAAGACTCATGAAATCAAGGTGAAAGGACAGAATTGA

Upstream 100 bases:

>100_bases
GATAATGGTCAATTGTTAATGAACAGTTAATTATAATAACGCCCAAAATATATTATTATTTAATTAAGTTAAATAAAATT
ATAGAAAGAAAGTGAAACTT

Downstream 100 bases:

>100_bases
TATGAAAATGAATAAATTAGTCAAATCATCCGTTGCTACATCTATGGCATTATTATTACTTTCTGGTACTGCTAATGCTG
AAGGTAAAATAACACCAGTC

Product: gamma hemolysin, component C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MLKNKILTTTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILK
MQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQILGYNIGGNFQSAPSLGGNGSF
NYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN

Sequences:

>Translated_315_residues
MLKNKILTTTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILK
MQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQILGYNIGGNFQSAPSLGGNGSF
NYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>Mature_315_residues
MLKNKILTTTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILK
MQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQILGYNIGGNFQSAPSLGGNGSF
NYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLGC_STAAC (Q5HDD4)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187223.1
- ProteinModelPortal:   Q5HDD4
- SMR:   Q5HDD4
- STRING:   Q5HDD4
- EnsemblBacteria:   EBSTAT00000010485
- GeneID:   3238447
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2421
- TIGR:   SACOL2421
- GeneTree:   EBGT00050000023901
- HOGENOM:   HBG693142
- OMA:   NTNHIKS
- ProtClustDB:   CLSK885582
- BioCyc:   SAUR93062:SACOL2421-MONOMER
- GO:   GO:0019835
- GO:   GO:0009405
- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183
- PRINTS:   PR01468
- TIGRFAMs:   TIGR01002

Pfam domain/function: PF07968 Leukocidin; SSF56959 Leukocidin/Porin

EC number: NA

Molecular weight: Translated: 35626; Mature: 35626

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKILTTTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQ
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCC
NIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYV
CCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEECCEEEEECCCCCCHHH
SLINYLPKNKIESTNVSQILGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQ
HHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
NSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
CCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCC
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKY
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEE
EVNWKTHEIKVKGQN
EECCEEEEEEEECCC
>Mature Secondary Structure
MLKNKILTTTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQ
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCC
NIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYV
CCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEEEECCEEEEECCCCCCHHH
SLINYLPKNKIESTNVSQILGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQ
HHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
NSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPS
CCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCC
FIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKY
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEE
EVNWKTHEIKVKGQN
EECCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA